[1]丁娟,莫基浩.胰岛素样生长因子ⅱ及胰岛素样生长因子结合蛋白-6血清水平与类风湿关节炎疾病活动度的关系研究[J].中医正骨,2023,35(11):10-13.
　DING Juan,MO Jihao.Relationships between serum levels of insulin-like growth factorⅡand insulin-like growth factor binding protein-6 and disease activity of rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(11):10-13.
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胰岛素样生长因子ⅱ及胰岛素样生长因子结合蛋白-6血清水平与类风湿关节炎疾病活动度的关系研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年11期
页码:
10-13
栏目:
临床研究
出版日期:
2023-11-20

文章信息/Info

Title:
Relationships between serum levels of insulin-like growth factorⅡand insulin-like growth factor binding protein-6 and disease activity of rheumatoid arthritis
作者:
丁娟; 莫基浩
河南省洛阳正骨医院/河南省骨科医院,河南 洛阳 471002
Author(s):
DING Juan; MO Jihao
Luoyang Orthopedic-Traumatological Hospital,Luoyang 471002,Henan,China
关键词:
关节炎; 类风湿;  胰岛素样生长因子Ⅱ;  胰岛素样生长因子结合蛋白质6;  28个关节疾病活动性评分
Keywords:
arthritis; rheumatoid;  insulin-like growth factorⅡ;  insulin-like growth factor binding protein 6;  disease activity score in 28 joints
摘要:
目的:探究胰岛素样生长因子Ⅱ(insulin-like growth factorⅡ,IGF-Ⅱ)及胰岛素样生长因子结合蛋白-6(insulin-like growth factor binding protein-6,IGFBP-6)血清水平与类风湿关节炎(rheumatoid arthritis,RA)疾病活动度的关系。方法:选取2019年2月至2020年12月收治的RA患者为研究对象,从病历系统中提取性别、年龄、体质量指数、病程、IGF-Ⅱ血清水平、IGFBP-6血清水平、28个关节疾病活动性评分(disease activity score in 28 joints,DAS28)。IGF-Ⅱ血清水平、IGFBP-6血清水平、DAS28均选择入院后24 h测定的结果。根据DAS28将患者分为高度活动组(DAS28>5.1分)、中度活动组(3.2分-1、(392.11±40.19)ng·mL-1、(472.39±39.76)ng·mL-1,3组患者的IGFBP-6血清水平分别为(502.67±39.86)ng·mL-1、(461.23±41.05)ng·mL-1、(386.51±43.17)ng·mL-1。轻度活动组和中度活动组的IGF-Ⅱ血清水平均低于高度活动组(P=0.003,P=0.000)、IGFBP-6血清水平均高于高度活动组(P=0.042,P=0.000); 轻度活动组的IGF-Ⅱ血清水平低于中度活动组(P=0.003),IGFBP-6血清水平高于中度活动组(P=0.042)。Spearman相关分析结果显示,IGF-Ⅱ血清水平与RA疾病活动度呈正相关(rs=0.720,P=0.000),IGFBP-6血清水平与RA疾病活动度呈负相关(rs=-0.671,P=0.001)。Logistic多因素回归分析结果显示,IGF-Ⅱ血清水平是RA疾病高度活动的危险因素[B=0.006,P=0.000,OR=1.007,95%CI(1.003,1.010)],IGFBP-6血清水平是RA疾病高度活动的保护因素[B=-0.008,P=0.000,OR=0.992,95%CI(0.989,0.995)]。结论:IGF-Ⅱ血清水平与RA疾病活动度呈正相关,IGFBP-6血清水平与RA疾病活动度呈负相关,二者可在一定程度上反映RA疾病活动度。
Abstract:
Objective:To explore the relationships between the serum levels of insulin-like growth factorⅡ(IGF-Ⅱ)and insulin-like growth factor binding protein-6(IGFBP-6)and the disease activity of rheumatoid arthritis(RA).Methods:The RA patients admitted from February 2019 to December 2020 were selected as the subjects,and the information including gender,age,body mass index,disease course,serum level of IGF-Ⅱ,serum level of IGFBP-6 and disease activity score in 28 joints(DAS28)was extracted from the Electronic Medical Record System(EMRS).The serum levels of IGF-Ⅱand IGFBP-6 and DAS28 measured at 24 hour after the hospital admission were selected.The patients were divided into high-activity group(DAS28>5.1 points),moderate-activity group(3.2 pointss=0.720,P=0.000),while a negative correlation between the serum level of IGFBP-6 and the disease activity of RA(rs=-0.671,P=0.001).The results of logistic multi-factor regression analysis showed that the increased serum level of IGF-Ⅱwas a risk factor for high disease activity in RA,while the increased serum level of IGFBP-6 acted as a protective factor against high disease activity in RA.Conclusion:The serum level of IGF-Ⅱis positively correlated with disease activity in RA,while the serum level of IGFBP-6 is negatively correlated with disease activity in RA,both of which can reflect the disease activity of RA to a certain extent.

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更新日期/Last Update: 1900-01-01