[1]雷桂平.血清网膜素在类风湿关节炎发病中的作用[J].中医正骨,2013,25(07):28-30.
　LEI Gui-ping*.*.Study on the effects of serum omentin in the onset of rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(07):28-30.
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血清网膜素在类风湿关节炎发病中的作用()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期数:
2013年07期
页码:
28-30
栏目:
临床研究
出版日期:
2013-07-31

文章信息/Info

Title:
Study on the effects of serum omentin in the onset of rheumatoid arthritis
作者:
雷桂平
湖南省株洲市中医伤科医院,湖南 株洲 412000
Author(s):
LEI Gui-ping*.*
TCM Traumatology Hospital of Zhuzhou City,Zhuzhou 412000,Hunan,China
关键词:
关节炎; 类风湿 网膜素 加味四藤汤
Keywords:
Arthritis; rheumatoid;  Omentin;  JIAWEI SITENG DECOCTION
摘要:
目的:探讨血清网膜素在类风湿关节炎发病中的作用。方法:按要求纳入48例类风湿关节炎患者(RA组)和45例健康志愿者(对照组)。RA组患者采用自拟加味四藤汤治疗,对照组不进行任何治疗。RA组患者于治疗前及治疗后3个月分别空腹14 h后采肘静脉血测定网膜素、红细胞沉降率、肿瘤坏死因子-α、白细胞介素-6、C反应蛋白; 对照组仅进行1次采血,并测定以上指标。以上指标的数据采集完毕后,分别将治疗前RA组与对照组各项指标、RA组治疗前后各项指标进行比较,同时对RA组患者血清网膜素含量与其余各项指标的关系进行分析。结果:①治疗前RA组及对照组的临床生化特征指标。治疗前RA组肿瘤坏死因子-α、白细胞介素-6、C反应蛋白、血沉和网膜素的水平均高于对照组[(2.901±0.720)μg·L-1,(0.815±0.411)μg·L-1;(8.043±3.706)ng·L-1,( 2.727±1.852)ng·L-1;(19.384±7.450)mg·L-1,(8.022±2.615)mg·L-1;(23.830±8.601)mm·h-1,(12.734±5.910)mm·h-1;(30.525±3.970)μg·L-1,(25.302±4.317)μg·L-1],差异有统计学意义(t=-2.712,P=0.000; t=3.971,P=0.000; t=-10.562,P=0.000; t=-8.477,P=0.000; t=5.175,P=0.000)。②RA组治疗前后的临床生化特征指标。治疗后RA组血清肿瘤坏死因子-α、白细胞介素-6和网膜素的含量降低[(1.305±0.226)μg·L-1,(6.290±2.651)ng·L-1,(18.952±3.308)mg·L-1,(22.985±3.250)mm·h-1,(26.271±3.683)μg·L-1],与治疗前比较差异有统计学意义(t=1.905,P=0.000; t=4.991,P=0.000; t=3.226,P=0.005); 治疗后C反应蛋白、血沉的水平[(18.952±3.308)mg·L-1,(22.985±3.250)mm·h-1]与治疗前比较,差异无统计学意义(t=2.157,P=0.113; t=3.401,P=0.098)。③血清网膜素含量与其他临床生化特征指标的关系。RA组网膜素与肿瘤坏死因子-α及白细胞介素-6呈正相关(r=0.723,P=0.011; r=0.480,P=0.027)。以血清网膜素为因变量,以血沉、C反应蛋白、白细胞介素-6、肿瘤坏死因子-α为自变量进行多元回归分析,结果表明肿瘤坏死因子-α是影响类风湿关节炎患者血清网膜素水平的独立相关因素,回归方程为Y网膜素=16.416+0.751X肿瘤坏死因子-α。经自拟加味四藤汤治疗后类风湿关节炎患者血清网膜素降低程度与肿瘤坏死因子-α降低程度呈正相关(r=0.481,P=0.035)。结论:网膜素参与了类风湿关节炎的发病,并可能在类风湿关节炎的炎症反应过程中对机体发挥一定的保护作用,其含量升高可能是其在炎症状态下的一种代偿机制。
Abstract:
Objective:To explore the effects of serum omentin in the onset of rheumatoid arthritis(RA).Methods:Forty-eight RA patients were included into RA group and 45 healthy volunteers were included into control group as requested.Patients in the RA group were administrated with self-designed JIAWEI SITENG DECOCTION,while the others in the control group were administrated with nothing.The following indexes were measured as omentin,erythrocyte sedimentation rate(ESR),tumor necrosis factor alpha(TNF-α),interleukin 6(IL-6)and C reactive protein(CRP)in the blood collected from ulnar vein of patients in RA group with fasting for 14 hours before the treatment and 3 months after the treatment respectively,while the volunteers in the control group were processed with blood collection only once for measuring above mentioned indexes.After completion of collecting above mentioned indexes,the indexes were compared between RA group and control group before the treatment,and were compared between pretreatment and post-treatment for RA group,meanwhile,the relationship between serum omentin contents and other indexes of patients in RA group were analyzed.Results:The levels of TNF-α,IL-6,CRP,ESR and omentin of RA group were all higher than those of control group before the treatment(2.901±0.720 vs 0.815±0.411μg/L,t=-2.712,P=0.000; 8.043±3.706 vs 2.727±1.852ng/L,t=3.971,P=0.000; 19.384±7.450 vs 8.022±2.615mg/L,t=-10.562,P=0.000; 23.830±8.601 vs 12.734±5.910mm/h,t=-8.477,P=0.000; 30.525±3.970 vs 25.302±4.317μg/L,t=5.175,P=0.000).Contents of TNF-α,IL-6 and omentin of RA group were all lowered after the treatment(1.305±0.226μg/L,6.290±2.651ng/L,18.952±3.308mg/L,22.985±3.250mm/h,26.271±3.683μg/L)and there were statistical difference between pretreatment and post-treatment(t=1.905,P=0.000; t=4.991,P=0.000; t=3.226,P=0.005).There was no statistical difference in the levels of CRP and ESR between pretreatment and post-treatment(19.384±7.450 vs 18.952±3.308mg/L,t=2.157,P=0.113; 23.830±8.601 vs 22.985±3.250mm/h,t=3.401,P=0.098).The contents of Omentin were correlated positively with those of TNF-α and IL-6 in RA group(r=0.723,P=0.011; r=0.480,P=0.027).Multiple regression analysis was performed with taking the contents of serum omentin as dependent variable,while ESR,CRP,IL-6 and TNF-α as independent variables,as a result,TNF-α was found to be the independent correlative factor which affectted serum omentin levels in RA patients(Regression equation,YOM=16.416+0.751XTNF-α).After the treatment with self-designed JIAWEI SITENG DECOCTION,reduction of serum omentin was correlated positively with that of TNF-α for the RA patients(r=0.481,P=0.035).Conclusion:Omentin takes part in RA onset and it may partly protect the organism in the process of inflammatory reaction of RA,and the increase of its content may be a kind of compensation for the inflammation.

参考文献/References:

[1] Yang RZ,Lee MJ,Hu H,et al.Identification of omentin as a novel depot-specific adipokine in human adipose tissue:possible role in modulating insulin action[J].Am J Physiol Endocrinol Metab,2006,290(6):E1253- E1261.
[2] Tan BK,Adya R,Farhatullah S,et al.Omentin-1,a novel adipokine,is decreased in overweight insulin-resistant women with polycystic ovary syndrome:ex vivo and in vivo regulation of omentin-1 by insulin and glucose[J].Diabetes,2008,57(4):801-808.
[3] Tan BK,Pua S,Syed F,et al.Decreased plasma omentin-1 levels in Type 1 diabetes mellitus[J].Diabet Med,2008,25(10):1254-1255.
[4] Senolt L,Polanská M,Filková M,et al.Vaspin and omentin:new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis[J].Ann Rheum Dis,2010,69(7):1410-1411.
[5] Arnett FC,Edworthy SM,Bloch DA,et al.The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis[J].Arthritis Rheum,1988,31(3):315-324.
[6] 胡伟.小剂量脉冲给药甲氨蝶呤对类风湿关节炎患者血清Vaspin的影响[J].实用医学杂志,2011,27(18):3408-3410.
[7] Kroot EJ,de Jong BA,van Leeuwen MA,et al.The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis[J].Arthritis Rheum,2000,43(8):1831-1835.
[8] 左川,杨南萍,彭晓东.抗角蛋白抗体在类风湿性关节炎的临床意义[J].中华风湿病学杂志,2004,8(2):97-99.
[9] Kuperman DA,Lewis CC,Woodruff PG,et al.Dissecting asthma using focused transgenic modeling and functional genomics[J].J Allergy Clin Immunol,2005,116(2):305-311.
[10] Schäffler A,Neumeier M,Herfarth H,et al.Genomic structure of human omentin,a new adipocytokine expressed in omental adipose tissue[J].Biochim Biophys Acta,2005,1732(1-3):96-102.
[11] 任彬,杨敏.四藤汤治疗类风湿性关节炎60例[J].陕西中医,2010,31(1):61-62.
[12] 黄喜茹,曹冬.马钱子研究进展[J].上海中医药杂志,2005,39(1):62-65.
[13] 王英豪.从化学、药理学和炮制的角度探讨附子、川乌和草乌的传统应用[J].光明中医,2009,24(9):1805-1806.
[14] 黄清春,陈纪藩,陈光星,等.通痹灵、雷公藤多甙及青藤碱对实验性关节炎大鼠滑膜组织病理影响的比较研究[J].中国医药学报,2003,18(1):12-13.
[15] 黄清春,陈光星,陈纪藩,等.通痹灵、雷公藤多苷及青藤碱对CIA大鼠滑膜细胞凋亡与P53表达的比较研究[J].中国医药学报,2003,18(11):660-662.

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更新日期/Last Update: 1900-01-01