[1]王笑青,张永红,侯宏理,等.顽痹清丸联合非甾体抗炎药及改善病情的抗风湿药治疗湿热痹阻型类风湿关节炎[J].中医正骨,2013,25(03):41-43.
　WANG Xiao-qing*,ZHANG Yong-hong,HOU Hong-li,et al.Curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs and disease modifying antirheumatic drugs in the treatment of rheumatoid arthritis of dampness-heat stagnation type[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(03):41-43.
点击复制

顽痹清丸联合非甾体抗炎药及改善病情的抗风湿药治疗 湿热痹阻型类风湿关节炎()
分享到：

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期数:
2013年03期
页码:
41-43
栏目:
临床研究
出版日期:
2013-03-20

文章信息/Info

Title:
Curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs and disease modifying antirheumatic drugs in the treatment of rheumatoid arthritis of dampness-heat stagnation type
作者:
王笑青; 张永红; 侯宏理; 王玉丽; 许素琴; 曹焱
河南省洛阳正骨医院,河南 洛阳 471002
Author(s):
WANG Xiao-qing*; ZHANG Yong-hong; HOU Hong-li; WANG Yu-li; XU Su-qin; CAO Yan.
*Luoyang Orthopedic-Traumatological Hospital,Luoyang 471002,Henan,China
关键词:
关节炎; 类风湿 痹证 顽痹清丸 消炎药; 非甾类 抗风湿药 治疗; 临床研究性
Keywords:
Arthritis; rheumatoid;  Arthralgia syndrome;  WANBIQING PILL;  Anti-inflammatory agents; non-steroidal;  Antirheumatic agents;  Therapies; investigational
摘要:
目的:观察顽痹清丸联合非甾体抗炎药及改善病情的抗风湿药治疗湿热痹阻型类风湿关节炎的临床疗效及安全性。方法:将53例湿热痹阻型类风湿关节炎患者随机分为2组,A组患者(25例)采用口服顽痹清丸联合双氯芬酸钠缓释胶囊、甲氨蝶呤片和来氟米特片治疗,B组患者(28例)采用口服安慰剂联合双氯芬酸钠缓释胶囊、甲氨蝶呤片和来氟米特片治疗。治疗8周后比较2组患者类风湿因子、血沉、C反应蛋白、关节疼痛评分变化情况及总体疗效。结果:①2组类风湿因子、血沉、C反应蛋白、VAS评分均较治疗前降低; 2组类风湿因子下降幅度比较,差异无统计学意义(t=0.071,P=0.944); A组血沉、C反应蛋白、关节疼痛评分下降幅度均大于B组(t=-5.305,P=0.000; t=-2.847,P=0.001; t=-4.807,P=0.000)。②A组临床疗效优于B组(Z=-2.600,P=0.009)。③A组1例患者出现白细胞计数降低,1例患者出现转氨酶增高,2例患者出现咽喉疼痛; B组1例患者出现转氨酶增高,3例患者出现咽喉疼痛。经对症处理后,2组患者的不良反应均消失。2组患者不良反应发生率比较,差异无统计学意义(χ2=0.000,P=1.000)。结论:采用顽痹清丸联合非甾体抗炎药及改善病情的抗风湿药治疗湿热痹阻型类风湿关节炎,可以有效地降低急性期反应物水平,缓解关节疼痛,疗效确切,且不良反应轻微,值得临床推广应用。
Abstract:
Objective:To observe the clinical curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs(NASIDs)and disease modifying antirheumatic drugs(DMARDs)in the treatment of rheumatoid arthritis(RA)of dampness-heat stagnation type.Methods:Fifty-three patients with RA of dampness-heat stagnation type were randomly divided into 2 groups,25 patients in group A were administrated with oral application of WANBIQING pills combined with diclofenac sodium sustained release capsules,methotrexate tablets and leflunomide tablets,while the others in group B were administrated with oral application of placebo combined with diclofenac sodium sustained release capsules,methotrexate tablets and leflunomide tablets.After eight-week treatment the 2 groups were compared with each other in such parameters as rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),C-reaction protein(CRP),changes of joint pain scores and total curative effects.Results:The RF,ESR,CRP and VAS of the 2 groups were all decreased compared with those before the treatment,and there was no statistical difference in decreasing degree of RF between the 2 groups(t=0.071,P=0.944),while the decreasing degrees of ESR,CRP and joint pain scores in group A were all greater than those in group B(t=-5.305,P=0.000; t=-2.847,P=0.001; t=-4.807,P=0.000).The clinical curative effect of group A was better than that of group B(Z=-2.600,P=0.009).One case with decreased white blood count,1 case with increased aminopherase and 2 cases with sore throat were found in group A,while 1 case with increased aminopherase and 3 cases with sore throat were found in group B.All of the adverse reactions disappeared after symptomatic treatment.There was no statistical difference in adverse reaction ratio between the 2 groups(χ2=0.000,P=1.000).Conclusion:The therapy of WANBIQING pills combined with NASIDs and DMARDs can effectively lower the acute phase reactant level and relieve the pain in joint when it is used in the treatment of RA of dampness-heat stagnation type,furthermore,it has certain curative effects with mild adverse reactions,so it is worthy of popularizing in clinic.

参考文献/References:

[1] 施桂英.关节炎概要[M].2版.北京:中国医药科技出版社,2005:366.
[2] Arnett FC,Edworth SM,Bloch DA,et al.The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis[S].Arthritis Rheum,1988,31(3):315.
[3] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:29.
[4] 张永红,李星星,沙莎.热痹的辨证论治[J].中医正骨,2012,24(4):64-67.
[5] 肖智.白虎桂枝汤加味治疗类风湿关节炎32例临床疗效[J].中医药导报,2010,16(9):38-39.
[6] 王晶,张万明,罗艳华.湿热痹冲剂治疗类风湿关节炎46例[J].中国地方病防治杂志,2012,27(4):313-314.
[7] 陈湘君.扶正法为主辨治类风湿性关节炎[J].上海中医药大学学报,2007,21(5):1-4.
[8] 李如意.中医分期辨证治疗类风湿性关节炎60例[J].甘肃中医学院学报,2006,23(1):38-39.

相似文献/References:

[1]邓伟哲,王宏晶,王宇恒,等.微创针刀镜治疗难治性膝关节类风湿关节炎[J].中医正骨,2015,27(11):42.
[2]李艺彬,朱勇,吴昭克.关节镜下多入路全关节滑膜清理术治疗肘关节类风湿关节炎[J].中医正骨,2015,27(11):56.
[3]齐新宇,向黎黎,熊辉,等.基于高蛋白饮食建立鸡痛风性关节炎模型的量效关系研究[J].中医正骨,2015,27(02):1.
　QI Xinyu,XIANG Lili,XIONG Hui,et al.A dose-effect relationship study of gouty arthritis chicken model built by high-protein diet[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):1.
[4]齐新宇,熊辉,周彪,等.蠲痹历节清方干预鸡急性痛风性关节炎模型的 实验研究[J].中医正骨,2015,27(03):5.
　QI Xinyu,XIONG Hui,ZHOU Biao,et al.Juanbilijieqing Fang(蠲痹历节清方)interfere with acute gouty arthritis chiken model[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):5.
[5]胡钢锋,肖鲁伟,童培建.关节液代谢组学在类风湿关节炎诊断 及寒热证候分型中的应用[J].中医正骨,2015,27(01):5.
　HU Gangfeng,XIAO Luwei,TONG Peijian.Application of joint fluid metabolomics to diagnosis and COLD-HEAT SYMPTOM COMPLEX typing in patients with rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):5.
[6]熊辉,曲良烨,向黎黎,等.痛风性关节炎湿热证病证结合模型的建立[J].中医正骨,2014,26(03):14.
　Xiong Hui*,Qu Liangye,Xiang Lili,et al.A rat model of gouty arthritis combined with dampness-heat syndrome[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(03):14.
[7]孙克民,王平,卢启贵,等.关节镜下滑膜切除术联合中药口服 治疗早期膝关节类风湿关节炎[J].中医正骨,2013,25(09):39.
[8]李峰,郭艳幸,曹向阳,等.贯叶连翘灌胃联合光动力疗法对类风湿关节炎白兔膝关节滑膜组织病理形态的影响[J].中医正骨,2014,26(09):6.
　Li Feng*,Guo Yanxing,Cao Xiangyang,et al.Effect of intragastric administration of hypericum perforatum combined with photodynamic therapy on the pathological morphology of synovial tissue of knee joints in rabbits with rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(03):6.
[9]严超,刘喜德,张金禄,等.蜂针疗法治疗膝骨性关节炎的护理[J].中医正骨,2013,25(01):74.
[10]黄建武,黄建华,林爱丽.扶中清痹通络汤联合益赛普对活动期类风湿关节炎患者肿瘤坏死因子-α及血管内皮生长因子血清含量的影响[J].中医正骨,2013,25(05):9.
　HUANG Jian-wu*,HUANG Jian-hua,LIN Ai-li.*.Effect of FUZHONG QINGBI TONGLUO decoction combined with etanercept on the serum contents of tumor necrosis factor-alpha and vascular endothelial growth factor in patients with active rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(03):9.

备注/Memo

备注/Memo:
基金项目:河南省科技发展计划项目(082102310095)
通讯作者:张永红 E-mail:lyzg123zhyh@163.com
更新日期/Last Update: 2013-03-20