[1]黄建武,黄建华,林爱丽.扶中清痹通络汤联合益赛普对活动期类风湿关节炎患者肿瘤坏死因子-α及血管内皮生长因子血清含量的影响[J].中医正骨,2013,25(05):9-11.
　HUANG Jian-wu*,HUANG Jian-hua,LIN Ai-li.*.Effect of FUZHONG QINGBI TONGLUO decoction combined with etanercept on the serum contents of tumor necrosis factor-alpha and vascular endothelial growth factor in patients with active rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(05):9-11.
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扶中清痹通络汤联合益赛普对活动期类风湿关节炎患者肿 瘤坏死因子-α及血管内皮生长因子血清含量的影响()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期数:
2013年05期
页码:
9-11
栏目:
基础研究
出版日期:
2013-05-31

文章信息/Info

Title:
Effect of FUZHONG QINGBI TONGLUO decoction combined with etanercept on the serum contents of tumor necrosis factor-alpha and vascular endothelial growth factor in patients with active rheumatoid arthritis
作者:
黄建武; 黄建华; 林爱丽
温州医学院附属第三医院,浙江 瑞安 325200
Author(s):
HUANG Jian-wu*; HUANG Jian-hua; LIN Ai-li.*
The Third Affiliated Hospital of Wenzhou Medical College,Rui'an 325200,Zhejiang,China
关键词:
关节炎; 类风湿 肿瘤坏死因子α 血管内皮生长因子类 扶中清痹通络汤 注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白 治疗; 临床研究性
Keywords:
Arthritis; rheumatoid;  Tumor necrosis factor-alpha;  Vascular endothelial growth factors;  FUZHONG QINGBI TONGLUO decoction;  Recombinant tumor necrosis factor alpha receptor:Fc fusion protein;  Therapies; investigational
摘要:
目的:观察扶中清痹通络汤联合益赛普对活动期类风湿关节炎患者血清肿瘤坏死因子-α及血管内皮生长因子含量的影响。方法:将纳入研究的69例活动期类风湿关节炎患者随机分为2组,治疗组35例采用口服扶中清痹通络汤联合皮下注射益赛普治疗,对照组34例采用皮下注射益赛普治疗。分别于治疗前和治疗3个月后抽取静脉血测定患者血清中肿瘤坏死因子-α及血管内皮生长因子的含量。结果:①肿瘤坏死因子-α血清含量。治疗前2组患者血清肿瘤坏死因子-α含量比较,差异无统计学意义(t=0.374,P=0.710); 治疗后2组患者血清肿瘤坏死因子-α含量均降低[(97.25±18.73)pg·mL-1,(58.98±12.34)pg·mL-1,t=10.094,P=0.000;(95.61±17.66)pg·mL-1,(65.23±10.37)pg·mL-1,t=8.650,P=0.000]; 治疗组的降低值大于对照组[(38.96±10.21)pg·mL-1,(31.15±8.43)pg·mL-1,t=3.459,P=0.001]。②血管内皮生长因子血清含量。治疗前2组患者血清血管内皮生长因子含量比较,差异无统计学意义(t=1.006,P=0.318); 治疗后2组患者血管内皮生长因子含量均降低[(85.12±16.56)pg·mL-1,(57.73±12.27)pg·mL-1,t=7.862,P=0.000;(81.42±13.83)pg·mL-1,(69.42±13.12)pg·mL-1,t=3.671,P=0.001]; 治疗组的降低值大于对照组[(29.54±8.78)pg·mL-1,(10.63±6.54)pg·mL-1,t=10.123,P=0.000]。结论:扶中清痹通络汤联合益赛普可降低活动期类风湿关节炎患者血清中肿瘤坏死因子-α和血管内皮生长因子的含量,其效果优于单独使用益赛普。
Abstract:
Objective:To observe the effect of FUZHONG QINGBI TONGLUO decoction combined with etanercept on the serum contents of tumor necrosis factor-alpha(TNF-α)and vascular endothelial growth factor(VEGF)in patients with active rheumatoid arthritis(RA).Methods:Sixty-nine patients with active RA enrolled in the study were randomly divided into 2 groups,35 cases in the treatment group were administrated with FUZHONG QINGBI TONGLUO decoction combined with subcutaneous injection of etanercept,while the others in the control group were administrated with subcutaneous injection of etanercept alone.The serum contents of TNF-α and VEGF were respectively detected before the treatment and 3 months after the treatment.Results:There was no statistical difference in serum contents of TNF-α between the 2 groups before the treatment(t=0.374,P=0.710); while the serum contents of TNF-α declined in the 2 groups after the treatment[(97.25±18.73)pg·mL-1,(58.98±12.34)pg·mL-1,t=10.094,P=0.000;(95.61±17.66)pg·mL-1,(65.23±10.37)pg·mL-1,t=8.650,P=0.000],and the treatment group had a more obvious decrease in serum contents of TNF-α than did the control group[(38.96±10.21)pg·mL-1,(31.15±8.43)pg·mL-1,t=3.459,P=0.001].There was no statistical difference in serum contents of VEGF between the 2 groups before the treatment(t=1.006,P=0.318); while the serum contents of VEGF declined in the 2 groups after the treatment[(85.12±16.56)pg·mL-1,(57.73±12.27)pg·mL-1,t=7.862,P=0.000;(81.42±13.83)pg·mL-1,(69.42±13.12)pg·mL-1,t=3.671,P=0.001],and the treatment group had a more obvious decrease in serum contents of VEGF than did the control group[(29.54±8.78)pg·mL-1,(10.63±6.54)pg·mL-1,t=10.123,P=0.000].Conclusion:The therapy of FUZHONG QINGBI TONGLUO decoction combined with etanercept can reduce the serum contents of TNF-α and VEGF in patients with active RA,and its effect is better than that of etanercept alone.

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更新日期/Last Update: 1900-01-01