[1]赵钰,李纪高,周全.虎杖有效成分基于类风湿关节炎相关信号通路治疗类风湿关节炎作用机制的研究进展[J].中医正骨,2023,35(04):28-32.
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虎杖有效成分基于类风湿关节炎相关信号通路治疗类风湿关节炎作用机制的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年04期
页码:
28-32
栏目:
综述
出版日期:
2023-04-20

文章信息/Info

作者:
赵钰1李纪高2周全2
(1.河南中医药大学第一临床医学院,河南 郑州 450046; 2.河南中医药大学第一附属医院,河南 郑州 450099)
关键词:
关节炎类风湿 虎杖 有效成分 信号传导 综述
摘要:
类风湿关节炎(rheumatoid arthritis,RA)是一种以侵蚀性关节炎为主要特征的慢性自身免疫性疾病,属中医学“痹证”“尪痹”范畴。虎杖用于治疗痹证由来已久,临床上采用含有虎杖的方剂治疗RA疗效显著。RA的发病机制尚未完全明确,Janus激酶/信号转导及转录激活因子、核因子-κB、促分裂原活化的蛋白激酶、磷脂酰肌醇3激酶/蛋白激酶B、Toll样受体4等多条信号通路与RA的发生发展关系密切。本文对虎杖有效成分基于上述信号通路治疗RA作用机制的研究进展进行了综述。

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(收稿日期:2022-10-20 本文编辑:吕宁)

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备注/Memo

备注/Memo:
基金项目:河南省自然科学基金青年项目(202300410254) 通讯作者:周全 E-mail:doctorzq@sina.com
更新日期/Last Update: 1900-01-01