参考文献/References:
[1] 王言,吴虹,邓然,等.关节滑膜炎性微环境对类风湿关节炎发生发展作用的研究进展[J].中国药理学通报,2020,36(6):754-759.
[2] SMOLEN J S,ALETAHA D,MCLNNES I B.Rheumatoid arthritis[J].Lancet,2016,388(10055):2023-2038.
[3] 刘斌,鲜艳思,郭保生,等.骨关节炎中滑膜炎症致病因素的研究进展[J].国际骨科学杂志,2023,44(5):274-278.
[4] DE HAIR M J,VAN DE SANDE M G,RAMWADHDOEBE T H,et al.Features of the synovium of individuals at risk of developing rheumatoid arthritis:implications for understanding preclinical rheumatoid arthritis[J].Arthritis Rheumatol,2014,66(3):513-522.
[5] MASOUMI M,BASHIRI H,KHORRAMDELAZAD H,et al.Destructive roles of fibroblast-like synoviocytes in chronic inflammation and joint damage in rheumatoid arthritis[J].Inflammation,2021,44(2):466-479.
[6] KOMATSU N,TAKAYANAGI H.Mechanisms of joint destruction in rheumatoid arthritis-immune cell-fibroblast-bone interactions[J].Nat Rev Rheumatol,2022,18(7):415-429.
[7] ZHENG Y,WEI K,JIANG P,et al.Macrophage polarization in rheumatoid arthritis:signaling pathways,metabolic reprogramming,and crosstalk with synovial fibroblasts[J].Front Immunol,2024,15:1394108.
[8] 戴冽,叶志强,汤美安,等.类风湿关节炎滑膜巨噬细胞来源的研究[J].中华风湿病学杂志,2000,4(2):103-105.
[9] 杨红梅,李浩林,杨娟娟,等.CXCL12/CXCR4在类风湿关节炎中的研究进展[J].中国药理学通报,2025,41(2):230-234.
[10] 蒋宇,汤郁,陈頔,等.类风湿关节炎患者CD4+ CD25+ CD127-调节性T细胞CXCR4的研究[J].南京医科大学学报(自然科学版),2023,43(4):459-467.
[11] 蒋昕,潘志,王颖航.基于Th17/Treg平衡对类风湿关节炎作用机制的研究概况[J].湖南中医药大学学报,2024,44(6):1117-1123.
[12] PARK S H,RHEE J,KIM S K,et al.BATF regulates collageninduced arthritis by regulating T helper cell differentiation[J].Arthritis Res Ther,2018,20(1):161.
[13] 李宏一,罗业浩,黄安.类风湿关节炎血管翳的形成及治疗的研究进展[J].广西医学,2022,44(15):1786-1790.
[14] 伍沙沙,王延,徐婷,等.成纤维样滑膜细胞在类风湿关节炎发病机制中的作用[J].风湿病与关节炎,2022,11(2):43-47.
[15] BARBARIC STARCEVIC K,LUKAC N,JELIC M,et al.Reciprocal alterations in osteoprogenitor and immune cell populations in rheumatoid synovia[J].Int J Mol Sci,2022,23(20):12379.
[16] SCHINOCCA C,RIZZO C,FASANO S,et al.Role of the IL-23/IL-17 pathway in rheumatic diseases:an overview[J].Front Immunol,2021,12:637829.
[17] WEI S T,SUN Y H,ZONG S H,et al.Serum levels of IL-6 and TNF-α may correlate with activity and severity of rheumatoid arthritis[J].Med Sci Monit,2015,21:4030-4038.
[18] CROFT A P,CAMPOS J,JANSEN K,et al.Distinct fibroblast subsets drive inflammation and damage in arthritis[J].Nature,2019,570(7760):246-251.
[19] CARMONA-RIVERA C,CARLUCCI P M,MOORE E,et al.Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis[J].Sci Immunol,2017,2(10):3358.
[20] FRAGOULIS G E,MCINNES I B,SIEBERT S.JAK-inhibitors.New players in the field of immune-mediated diseases,beyond rheumatoid arthritis[J].Rheumatology(Oxford),2019,58(Suppl 1):43-54.
[21] MIHARA M,HASHIZUME M,YOSHIDA H,et al.IL-6/IL-6 receptor system and its role in physiological and pathological conditions[J].Clin Sci(Lond),2012,122(4):143-159.
[22] YANG H,LUO Y,LAI X.CD5L induces inflammation and survival in RA-FLS through ERK1/2 MAPK pathway[J].Autoimmunity,2024,57(1):2201412.
[23] ZHANG F,WEI K,SLOWIKOWSKI K,et al.Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry[J].Nat Immunol,2019,20(7):928-942.
[24] GENT Y Y,AHMADI N,VOSKUYL A E,et al.Detection of subclinical synovitis with macrophage targeting and positron emission tomography in patients with rheumatoid arthritis without clinical arthritis[J].J Rheumatol,2014,41(11):2145-2152.
[25] LUO M,ZHAO F,CHENG H,et al.Macrophage polarization:an important role in inflammatory diseases[J].Front Immunol,2024,15:1352946.
[26] FUKUI S,IWAMOTO N,TAKATANI A,et al.M1 and M2 monocytes in rheumatoid arthritis:a contribution of imba-lance of M1/M2 monocytes to osteoclastogenesis[J].Front Immunol,2018,8:1958.
[27] 张克恭,何文昌,郭小凤,等.中性粒细胞胞外诱捕网形成机制的研究进展[J].细胞与分子免疫学杂志,2020,36(6):561-564.
[28] 宋子怡,张升校,苏勤怡,等.中性粒细胞胞外诱捕网在类风湿关节炎发病机制中的研究进展[J].医学研究杂志,2023,52(7):15-18.
[29] 常永龙,郭锦晨.中性粒细胞胞外诱捕网在类风湿关节炎免疫炎症中的研究进展[J].风湿病与关节炎,2022,11(2):66-70.
[30] O'NEIL L J,OLIVEIRA C B,WANG X,et al.Neutrophil extracellular trap-associated carbamylation and histones trigger osteoclast formation in rheumatoid arthritis[J].Ann Rheum Dis,2023,82(5):630-638.
[31] MAO J,TAN M,LI J,et al.Neutrophil extracellular traps induce pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes via the NF-kappaB/Caspase 3/GSDME path-way[J].Inflammation,2024,47(3):921-938.
[32] 张柯,董俊杰,徐艳,等.类风湿性关节炎患者外周血中性粒细胞胞外诱捕网的水平及其临床意义[J].辽宁医学杂志,2025,39(1):29-32.
[33] KRIL I,HAVRYLYUK A,POTOMKINA H,et al.Apoptosis and secondary necrosis of neutrophils and monocytes in the immunopathogenesis of rheumatoid arthritis:a cohort study[J].Rheumatol Int,2020,40(9):1449-1454.
[34] MATSUSHIMA K,YANG D,OPPENHEIM J J.Interleukin-8:an evolving chemokine[J].Cytokine,2022,153:155828.
[35] BOURQUE J,HAWIGER D.Immunomodulatory bonds of the partnership between dendritic cells and T Cells[J].Crit Rev Immunol,2018,38(5):379-401.
[36] PARADOWSKA-GORYCKA A,WAJDA A,ROMANOWSKA-PRCHNICKA K,et al.Th17/treg-related transcriptional factor expression and cytokine profile in patients with rheumatoid arthritis[J].Front Immunol,2020,11:572858.
[37] ZHANG R,MIAO J,ZHANG K,et al.Th1-like treg cells are increased but deficient in function in rheumatoid arthritis[J].Front Immunol,2022,13:863753.
[38] 李春灵,楚天舒.细胞代谢对调控类风湿关节炎调节性T细胞/辅助性T细胞17平衡的研究进展[J].中华风湿病学杂志,2023,27(3):191-194.
[39] LI B,SU R,GUO Q,et al.Differential immunological profiles in seronegative versus seropositive rheumatoid arthritis:Th17/Treg dysregulation and IL-4[J].Front Immunol,2024,15:1447213.
[40] HUMBY F,DUREZ P,BUCH M H,et al.Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis(R4RA):16-week outcomes of a stratified, biopsy-driven,multicentre,open-label phase 4 randomised controlled trial[J].Lancet,2021,397(10271):305-317.
[41] WU Z,MA D,YANG H,et al.Fibroblast-like synoviocytes in rheumatoid arthritis:surface markers and phenotypes[J].Int Immunopharmacol,2021,93:107392.
[42] MIN H K,KIM S H,LEE J Y,et al.DJ-1 controls T cell diffe-rentiation and osteoclastogenesis in rheumatoid arthritis[J].Sci Rep,2022,12(1):12767.
[43] COHEN S B,DORE R K,LANE N E,et al.Denosumab treatment effects on structural damage,bone mineral density,and bone turnover in rheumatoid arthritis:a twelve-month,multicenter, randomized, double-blind,placebo-controlled,phase II clinical trial[J].Arthritis Rheum,2008,58(5):1299-1309.
[44] YAO Z,GETTING S J,LOCKE I C.Regulation of TNF-Induced osteoclast differentiation[J].Cells,2021,11(1):132.
[45] LOH C,PARK S H,LEE A,et al.TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes:transcriptomic and epigenomic analysis[J].Ann Rheum Dis,2019,78(9):1205-1214.
[46] XIA Z B,MENG F R,FANG Y X,et al.Inhibition of NF-κB signaling pathway induces apoptosis and suppresses prolife-ration and angiogenesis of human fibroblast-like synovial cells in rheumatoid arthritis[J].Medicine(Baltimore),2018,97(23):e10920.
[47] CIOBANU D A,POENARIU I S,CR?NGUS L I,et al.JAK/STAT pathway in pathology of rheumatoid arthritis(Review)[J].Exp Ther Med,2020,20(4):3498-3503.
[48] MONARI C,BEVILACQUA S,PICCIONI M,et al.A microbial polysaccharide reduces the severity of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production[J].J Immunol,2009,183(1):191-200.
[49] STUMP K L,LU L D,DOBRZANSKI P,et al.A highly selective,orally active inhibitor of Janus kinase 2,CEP-33779,ablates disease in two mouse models of rheumatoid arthri-tis[J].Arthritis Res Ther,2011,13(2):R68.
[50] KANEKO Y,OZAWA S I,SATO Y,et al.The Stat3 inhibitor F0648-0027 is a potential therapeutic against rheumatoid arthritis[J].Biochem Biophys Res Commun,2022,636(Pt 2):133-140.
[51] ZHANG L L,XIAO H,ZHANG F,et al.BAFF,involved in B cell activation through the NF-κB pathway,is related to disease activity and bone destruction in rheumatoid arthri-tis[J].Acta Pharmacol Sin,2021,42(10):1665-1675.
[52] PUJARI R,ELIGAR S M,KUMAR N,et al.CD45-mediated signaling pathway is involved in Rhizoctonia bataticola lectin(RBL)-induced proliferation and Th1/Th2 cytokine secretion in human PBMC[J].Biochem Biophys Res Commun,2012,419(4):708-814.
[53] HOT A,ZRIOUAL S,TOH M L,et al.IL-17A-versus IL-17F-induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in rheumatoid synoviocytes[J].Ann Rheum Dis,2011,70(2):341-348.
[54] XUAN W,FENG X,QIAN C,et al.Osteoclast differentiation gene expression profiling reveals chemokine CCL4 mediates RANKL-induced osteoclast migration and invasion via PI3K pathway[J].Cell Biochem Funct,2017,35(3):171-177.
[55] SMITH C I E,BURGER J A.Resistance mutations to BTK inhibitors originate from the NF-κB but not from the PI3K-RAS-MAPK arm of the B cell receptor signaling pathway[J].Front Immunol,2021,12:689472.
[56] PAVLASOVA G,MRAZ M.The regulation and function of CD20:an “enigma” of B-cell biology and targeted therapy[J].Haematologica,2020,105(6):1494-1506.
[57] ARNESON L C,CARROLL K J,RUDERMAN E M.Bruton's tyrosine kinase inhibition for the treatment of rheumatoid arthritis[J].Immunotargets Ther,2021,10:333-342.
[58] LIU Y T,DING H H,LIN Z M,et al.A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis[J].Acta Pharmacol Sin,2021,42(10):1653-1664.
[59] WANG R,LI M,WU W,et al.NAV2 positively modulates inflammatory response of fibroblast-like synoviocytes through activating Wnt/β-catenin signaling pathway in rheumatoid arthritis[J].Clin Transl Med,2021,11(4):e376.
[60] WEI K,KORSUNSKY I,MARSHALL J L,et al.Notch signalling drives synovial fibroblast identity and arthritis pathology[J].Nature,2020,582(7811):259-264.
[61] ZHAO F,HE Y,ZHAO Z,et al.The Notch signaling-regulated angiogenesis in rheumatoid arthritis:pathogenic mechanisms and therapeutic potentials[J].Front Immunol,2023,14:1272133.
[62] CHEN J,LI J,CHEN J,et al.Treatment of collagen-induced arthritis rat model by using Notch signalling inhibitor[J].J Orthop Translat,2021,28:100-107.
[63] SMOLEN J S,LANDEW? R B M,BERGSTRA S A,et al.EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs:2022 update[J].Ann Rheum Dis,2023,82(1):3-18.
[64] FRAENKEL L,BATHON J M,ENGLAND B R,et al.2021 American College of Rheumatology guideline for the treat-ment of rheumatoid arthritis[J].Arthritis Rheumatol,2021,73(7):924-939.
[65] 马剑达,戴冽.美国风湿病学会发布2020年类风湿关节炎药物治疗指南(草案)[J].中华风湿病学杂志,2021,25(4):286-288.
[66] 国家皮肤与免疫疾病临床医学研究中心(北京协和医院),中国医师协会风湿免疫专科医师分会,中国康复医学会风湿免疫病康复专业委员会,等.2024中国类风湿关节炎诊疗指南[J].中华内科杂志,2024,63(11):1059-1077.
[67] 赵璐,曹宇婷,刘薇,等.类风湿性关节炎靶向治疗药物的回顾及展望[J].世界临床药物,2023,44(11):1139-1143.
[68] 孟梅,岳正刚,周瑞,等.靶向类风湿关节炎细胞因子与信号通路的治疗药物进展[J].中国药学杂志,2021,56(8):620-625.
[69] 姜平,常岑,许林帅,等.类风湿关节炎治疗的进展与挑战[J].中国药学杂志,2024,59(3):200-209.
[70] 姜楠,田新平,曾小峰.《2024中国类风湿关节炎诊疗指南》解读[J].协和医学杂志,2025,16(1):28-34.
[71] 《中成药治疗优势病种临床应用指南》标准化项目组.中成药治疗类风湿关节炎临床应用指南(2022年)[J].中国中西医结合杂志,2023,43(3):261-273.
[72] 王靖霞,刘春芳,李逸群,等.雷公藤多苷片抑制实验性类风湿关节炎血管新生的作用研究[J].中国中药杂志,2019,44(16):3441-3447.
[73] 张炜,王莉,杨雨欣,等.黄芩苷调节let-7i-3p/PI3K/Akt/NF-κB信号轴减轻类风湿关节炎成纤维样滑膜细胞NLRP3炎性小体活化[J].中国药理学通报,2023,39(12):2313-2319.
[74] 顾庆香,刘维,丁久力,等.丹参酮ⅡA治疗类风湿关节炎的作用机制[J].中医学报,2024,39(11):2381-2385.
[75] 管咏梅,万志艳,王舒慧,等.基于NF-κB、Nrf2/HO-1信号通路及Bcl-2/Caspase-3凋亡蛋白表达探讨雷公藤-川芎组分配伍对类风湿关节炎成纤维样滑膜细胞的影响[J].中国实验方剂学杂志,2025,31(2):17-26.
[76] 赵阳扣,邓家枫,范郁山.针灸治疗类风湿关节炎的基础研究进展及思考[J].江西中医药,2024,55(11):72-76.
[77] 李红晓,吉跃进,张旭.5种针刺方法治疗类风湿关节炎的网状Meta分析[J].中华中医药学刊,2020,38(3):154-159.
[78] 陆文婷,罗小超,尚娅男,等.艾灸对类风湿关节炎模型动物血清细胞因子干预作用的系统评价与Meta分析[J].针刺研究,2020,45(9):751-761.
[79] EBINA K,HASHIMOTO M,YAMAMOTO W,et al.Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis—the ANSWER cohort study[J].Arthritis Res Ther,2019,21(1):91.
[80] TANAKA Y.Recent progress in treatments of rheumatoid arthritis:an overview of developments in biologics and small molecules, and remaining unmet needs[J].Rheumatology(Oxford),2021,60(Suppl 6):vi12-vi20.
相似文献/References:
[1]齐新宇,向黎黎,熊辉,等.基于高蛋白饮食建立鸡痛风性关节炎模型的量效关系研究[J].中医正骨,2015,27(02):1.
QI Xinyu,XIANG Lili,XIONG Hui,et al.A dose-effect relationship study of gouty arthritis chicken model built by high-protein diet[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):1.
[2]齐新宇,熊辉,周彪,等.蠲痹历节清方干预鸡急性痛风性关节炎模型的
实验研究[J].中医正骨,2015,27(03):5.
QI Xinyu,XIONG Hui,ZHOU Biao,et al.Juanbilijieqing Fang(蠲痹历节清方)interfere with acute gouty arthritis chiken model[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):5.
[3]熊辉,曲良烨,向黎黎,等.痛风性关节炎湿热证病证结合模型的建立[J].中医正骨,2014,26(03):14.
Xiong Hui*,Qu Liangye,Xiang Lili,et al.A rat model of gouty arthritis combined with dampness-heat syndrome[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(09):14.
[4]孙克民,王平,卢启贵,等.关节镜下滑膜切除术联合中药口服
治疗早期膝关节类风湿关节炎[J].中医正骨,2013,25(09):39.
[5]李峰,郭艳幸,曹向阳,等.贯叶连翘灌胃联合光动力疗法对类风湿关节炎白兔膝关节滑膜组织病理形态的影响[J].中医正骨,2014,26(09):6.
Li Feng*,Guo Yanxing,Cao Xiangyang,et al.Effect of intragastric administration of hypericum perforatum combined with photodynamic therapy on the pathological morphology of synovial tissue of knee joints in rabbits with rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(09):6.
[6]严超,刘喜德,张金禄,等.蜂针疗法治疗膝骨性关节炎的护理[J].中医正骨,2013,25(01):74.
[7]王笑青,张永红,侯宏理,等.顽痹清丸联合非甾体抗炎药及改善病情的抗风湿药治疗湿热痹阻型类风湿关节炎[J].中医正骨,2013,25(03):41.
WANG Xiao-qing*,ZHANG Yong-hong,HOU Hong-li,et al.Curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs and disease modifying antirheumatic drugs in the treatment of rheumatoid arthritis of dampness-heat stagnation type[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(09):41.
[8]黄建武,黄建华,林爱丽.扶中清痹通络汤联合益赛普对活动期类风湿关节炎患者肿瘤坏死因子-α及血管内皮生长因子血清含量的影响[J].中医正骨,2013,25(05):9.
HUANG Jian-wu*,HUANG Jian-hua,LIN Ai-li.*.Effect of FUZHONG QINGBI TONGLUO decoction combined with etanercept on the serum contents of tumor necrosis factor-alpha and vascular endothelial growth factor in patients with active rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(09):9.
[9]赫军,李丽华,王相奇,等.痛风四妙汤加味治疗痛风性关节炎[J].中医正骨,2013,25(05):56.
[10]雷桂平.血清网膜素在类风湿关节炎发病中的作用[J].中医正骨,2013,25(07):28.
LEI Gui-ping*.*.Study on the effects of serum omentin in the onset of rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(09):28.
[11]邓伟哲,王宏晶,王宇恒,等.微创针刀镜治疗难治性膝关节类风湿关节炎[J].中医正骨,2015,27(11):42.
[12]李艺彬,朱勇,吴昭克.关节镜下多入路全关节滑膜清理术治疗肘关节类风湿关节炎[J].中医正骨,2015,27(11):56.
[13]胡钢锋,肖鲁伟,童培建.关节液代谢组学在类风湿关节炎诊断
及寒热证候分型中的应用[J].中医正骨,2015,27(01):5.
HU Gangfeng,XIAO Luwei,TONG Peijian.Application of joint fluid metabolomics to diagnosis and COLD-HEAT SYMPTOM COMPLEX typing in patients with rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):5.
[14]杨晓峰.超声和MRI检查在类风湿关节炎手腕部病变诊断中的应用[J].中医正骨,2018,30(05):24.
[15]龚辉,邓奕辉,王衡新,等.TOLL样受体2、4及其介导的NF-κB信号通路参与类风湿关节 炎发病的研究进展[J].中医正骨,2018,30(07):29.
[16]高保红,路艳,赵艳菊,等.个性化功能锻炼在类风湿关节炎护理中的应用[J].中医正骨,2019,31(06):77.
[17]吴海洋.骨髓间充质干细胞移植对胶原诱导性关节炎大鼠血清细胞因子的影响[J].中医正骨,2019,31(08):14.
WU Haiyang.Effects of bone marrow mesenchymal stem cells transplantation on serum cytokines in rats with collagen-induced arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(09):14.
[18]伊力夏提·买买提,帕尔哈提·热甫开提,热扑开提·赛吾力丁,等.维医诊疗类风湿关节炎的学术思想探讨[J].中医正骨,2020,32(08):45.
[19]杨群政,章先锋,陈英,等.类风湿关节炎与骨质疏松症的关系研究[J].中医正骨,2021,33(02):26.
YANG Qunzheng,ZHANG Xianfeng,CHEN Ying,et al.A clinical study on the relationships between rheumatoid arthritis and osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(09):26.
[20]张华燕,何援军.薯蓣皂苷元改善类风湿关节炎模型大鼠关节肿胀的效果及作用机制研究[J].中医正骨,2021,33(04):44.
ZHANG Huayan,HE Yuanjun.Efficacy and mechanism of diosgenin against joint swelling in rat models with rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(09):44.