参考文献/References:
[1] 梁文娜,沈建英,闵莉.绝经后骨质疏松症肾虚证与骨髓基质干细胞分化失衡内在联系的探微[J].中华中医药杂志,2020,35(10):4794-4796.
[2] COSMAN F.Long-term treatment strategies for postmeno-pausal osteoporosis[J].Curr Opin Rheumatol,2018,30(4):420-426.
[3] YANG L,SATO M,SAITO-ABE M,et al.25-Hydroxyvitamin D levels among 2-year-old children:findings from the Japan environment and children's study(JECS)[J].BMC Pediatr,2021,21(1):539.
[4] RAJAKUMAR K,HOLICK M F,MOORE C G,et al.Impact of seasonal flux on 25-hydroxyvitamin D and bone turnover in pre-and early pubertal youth[J].Pediatr Int,2014,56(1):35-42.
[5] DOMÍNGUEZ-MENÉNDEZ G,POGGI H,MOORE R,et al.Seasonal variations in 25-hydroxy vitamin D3,parathormone and alkaline phosphatase in school-aged children[J].Rev Chil Pediatr,2020,91(6):881-890.
[6] LIN J,CHEN L,NI S,et al.Association between sleep quality and bone mineral density in Chinese women vary by age and menopausal status[J].Sleep Med,2019,53:75-80.
[7] ZHU Y,LIU S,CHEN W,et al.Epidemiology of low-energy fracture in Chinese postmenopausal women:changing trend of incidence since menopause and associated risk factors,a national population-based survey[J].Menopause,2019,26(3):286-292.
[8] WU Q Y,WANG J,TONG X,et al.Emerging role of circadian rhythm in bone remodeling[J].J Mol Med(Berl),2019,97(1):19-24.
[9] SWANSON C M,KOHRT W M,BUXTON O M,et al.The importance of the circadian system & sleep for bone health[J].Metabolism,2018,84:28-43.
[10] 李欢,徐尚福,刘杰.生物钟基因:中药作用的新靶点[J].中华中医药杂志,2017,32(12):5464-5467.
[11] HIRAI T,TANAKA K,TOGARI A.β-adrenergic receptor signaling regulates Ptgs2 by driving circadian gene expre-ssion in osteoblasts[J].J Cell Sci,2014,127(17):3711-3719.
[12] HIRAI T,TANAKA K,TOGARI A.α1B-Adrenergic receptor signaling controls circadian expression of Tnfrsf11b by regulating clock genes in osteoblasts[J].Biol Open,2015,4(11):1400-1409.
[13] HIRAI T,TANAKA K,TOGARI A.α1-adrenergic receptor signaling in osteoblasts regulates clock genes and bone morphogenetic protein 4 expression through up-regulation of the transcriptional factor nuclear factor IL-3(Nfil3)/E4 promoter-binding protein 4(E4BP4)[J].J Biol Chem,2014,289(24):17174-17183.
[14] SCHILPEROORT M,KROON J,KOOIJMAN S,et al.Loss of glucocorticoid rhythm induces an osteoporotic phenotype in female mice[J].Aging Cell,2021,20(10):e13474.
[15] FUJIHARA Y,KONDO H,NOGUCHI T,et al.Glucocorticoids mediate circadian timing in peripheral osteoclasts resulting in the circadian expression rhythm of osteoclast-related genes[J].Bone,2014,61:1-9.
[16] HANYU R,HAYATA T,NAGAO M,et al.Per-1 is a speci-fic clock gene regulated by parathyroid hormone(PTH)signaling in osteoblasts and is functional for the transcriptional events induced by PTH[J].J Cell Biochem,2011,112(2):433-438.
[17] KUNIMOTO T,OKUBO N,MINAMI Y,et al.A PTH-responsive circadian clock operates in ex vivo mouse femur fracture healing site[J].Sci Rep,2016,6:22409.
[18] MUNMUN F,WITT-ENDERBY P A.Melatonin effects on bone:Implications for use as a therapy for managing bone loss[J].J Pineal Res,2021,71(1):e12749.
[19] MACDONALD I J,TSAI H C,CHANG A C,et al.Melatonin inhibits osteoclastogenesis and osteolytic bone metastasis:implications for osteoporosis[J].Int J Mol Sci,2021,22(17):9435.
[20] FU L,PATEL M S,BRADLEY A,et al.The molecular clock mediates leptin-regulated bone formation[J].Cell,2005,122(5):803-815.
[21] MARONDE E,SCHILLING A F,SEITZ S,et al.The clock genes period 2 and cryptochrome 2 differentially balance bone formation[J].PLoS One,2010,5(7):e11527.
[22] SAMSA W E,VASANJI A,MIDURA R J,et al.Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype[J].Bone,2016,84:194-203.
[23] MIN H Y,KIM K M,WEE G,et al.BMAL1 induces osteoblast differentiation via regulation of BMP2 expression in MC3T3-E1 cells[J].Life Sci,2016,162:41-46.
[24] XU C,OCHI H,FUKUDA T,et al.Circadian clock regulates bone resorption in mice[J].J Bone Miner Res,2016,31(7):1344-1355.
[25] DUDEK M,MENG Q J.Running on time:the role of circadian clocks in the musculoskeletal system[J].Biochem J,2014,463(1):1-8.
[26] GIBBS J E,BLAIKLEY J,BEESLEY S,et al.The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines[J].Proc Natl Acad Sci U S A,2012,109(2):582-587.
[27] KIM K,KIM J H,KIM I,et al.Rev-erbα negatively regulates osteoclast and osteoblast differentiation through p38 MAPK signaling pathway[J].Mol Cells,2020,43(1):34-47.
[28] TIAN Y,GONG Z,ZHAO R,et al.Melatonin inhibits RANKL-induced osteoclastogenesis through the miR-882/Rev-erbα axis in Raw264.7 cells[J].Int J Mol Med,2021,47(2):633-642.
[29] HE Y,LIN F,CHEN Y,et al.Overexpression of the circadian clock gene Rev-erbα affects murine bone mesenchymal stem cell proliferation and osteogenesis[J].Stem Cells Dev,2015,24(10):1194-1204.
[30] 胡巍,王译凡,袁一方,等.节律基因调控成骨和破骨活动机制的研究进展[J].国际口腔医学杂志,2019,46(3):302-307.
[31] MEYER T,KNEISSEL M,MARIANI J,et al.In vitro and in vivo evidence for orphan nuclear receptor RORalpha function in bone metabolism[J].Proc Natl Acad Sci U S A,2000,97(16):9197-9202.
[32] KAWAI M,GREEN CB,LECKA-CZERNIK B,et al.A circadian-regulated gene,Nocturnin,promotes adipogenesis by stimulating PPAR-gamma nuclear translocation[J].Proc Natl Acad Sci U S A,2010,107(23):10508-10513.
[33] KAWAI M,ROSEN CJ.PPARγ:a circadian transcription factor in adipogenesis and osteogenesis[J].Nat Rev Endocrinol,2010,6(11):629-636.
[34] CHEN W,CHEN X,CHEN A C,et al.Melatonin restores the osteoporosis-impaired osteogenic potential of bone ma-rrow mesenchymal stem cells by preserving SIRT1-mediated intracellular antioxidant properties[J].Free Radic Biol Med,2020,146:92-106.
[35] TSUKAMOTO-YAMAUCHI N,TERASAKA T,IWASAKI Y,et al.Interaction of pituitary hormones and expression of clock genes modulated by bone morphogenetic protein-4 and melatonin[J].Biochem Biophys Res Commun,2015,459(1):172-177.
[36] XU J,LOMBARDI G,JIAO W,et al.Effects of exercise on bone status in female subjects,from young girls to post-menopausal women:an overview of systematic reviews and meta-analyses[J].Sports Med,2016,46(8):1165-1182.
[37] 李建军,蔡榕琪,孟依临,等.特定冬季服用补肾中药对绝经后骨质疏松症患者骨吸收影响的研究[J].世界中医药,2017,12(9):2109-2113.
[38] 蔡榕琪,孟依临,毕晋,等.冬夏使用补肾中药治疗绝经后骨质疏松症临床研究[J].天津中医药大学学报,2019,38(2):139-142.
[39] MANIOS Y,MOSCHONIS G,LYRITIS G P.Seasonal variations of vitamin D status in Greek postmenopausal women receiving enriched dairy products for 30 months:the post-menopausal health study[J].Eur J Clin Nutr,2011,65(3):412-414.
[40] MICIC I,JEON I H,PARK S H,et al.The effect of short-term low-energy ultraviolet B irradiation on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis:a randomized single-blinded controlled clinical trial[J].Srp Arh Celok Lek,2013,141(9/10):615-622.
[41] 张改,陈玉梅,李淑芳,等.5117例股骨颈骨折患者流行病学调查分析[J].天津护理,2021,29(5):505-508.
[42] MAZZUCCHELLI R,CRESPÍ-VILLARÍAS N,PÉREZ-FERNÁNDEZ E,et al.Weather conditions and their effect on seasonality of incident osteoporotic hip fracture[J].Arch Osteoporos,2018,13(1):28.
[43] EASTELL R,DIJK D J,SMALL M,et al.Morning vs evening dosing of the cathepsin K inhibitor ONO-5334:effects on bone resorption in postmenopausal women in a rando-mized,phase 1 trial[J].Osteoporos Int,2016,27(1):309-318.
[44] LUCHAVOVA M,ZIKAN V,MICHALSKA D,et al.The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis[J].Eur J Endocrinol,2011,164(4):643-648.
[45] ANDO H,OTODA T,OOKAMI H,et al.Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis[J].Clin Exp Pharmacol Physiol,2013,40(3):227-232.
[46] FU X,ZHAO X,LU H,et al.Association between sleep duration and bone mineral density in Chinese women[J].Bone,2011,49(5):1062-1066.
[47] LIN J,CHEN L,NI S,et al.Association between sleep qua-lity and bone mineral density in Chinese women vary by age and menopausal status[J].Sleep Med,2019,53:75-80.
[48] SCHILPEROORT M,BRAVENBOER N,LIM J,et al.Circadian disruption by shifting the light-dark cycle negatively affects bone health in mice[J].FASEB J,2020,34(1):1052-1064.
[49] REN B,MA C,CHEN L,et al.Impact of time-restricted feeding to late night on adaptation to a 6 h phase advance of the light-dark cycle in mice[J].Front Physiol,2021,12:634187.
(收稿日期:2022-07-14 本文编辑:吕宁)
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