[1]刘晨,李兴勇,姚兴璋,等.绝经后骨质疏松症的流行病学概况及发病机制研究进展[J].中医正骨,2018,30(03):52-55,58.
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绝经后骨质疏松症的流行病学概况及发病机制研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期数:
2018年03期
页码:
52-55,58
栏目:
综述
出版日期:
2018-03-20

文章信息/Info

作者:
刘晨1李兴勇2姚兴璋3杨博文1董世健1刘学睿3
1.甘肃中医药大学,甘肃 兰州 730000; 2.甘肃省第三人民医院,甘肃 兰州 730050; 3.甘肃省中医院,甘肃 兰州 730050
关键词:
骨质疏松绝经后 流行病学研究 肠道菌群失调 氧化性应激 骨髓 间质干细胞 综述
摘要:
绝经后骨质疏松症临床较为常见,发病机制复杂,与绝经后体内雌激素水平急剧下降等因素有关。为了更好地防治绝经后骨质疏松症,本文对其流行病学情况进行了概述,并从肠道菌群失调、氧化应激及骨髓间充质干细胞异常分化3个方面对其发病机制的研究进展进行了综述。

参考文献/References:

[1] COLE ZA,DENNISON EM,COOPER C.Osteoporosis epidemiology update[J].Curr Rheumatol Rep,2008,10(2):92-96.
[2] 陈林,程军,李波,等.渝东北地区老年人骨质疏松流行病学调查[J].中国骨质疏松杂志,2016,22(8):1050-1052.
[3] 刘峰.骨质疏松流行病学及防治研究进展[J].医学理论与实践,2017,30(22):3321-3322.
[4] 韩亚军,帖小佳,伊力哈木·托合提.中国中老年人骨质疏松症患病率的Meta分析[J].中国组织工程研究,2014,18(7):1129-1134.
[5] 乔芳,常静.骨质疏松流行病学调查分析[J].中国实用医药,2012,7(30):271-272.
[6] QIN J,LI R,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[7] VITAL M,HOWE AC,TIEDJE JM.Revealing the bacterial butyrate synthesis pathways by analyzing(meta)genomic data[J].MBio,2014,5(2):889.
[8] FRANSEN F,VAN BEEK AA,BORGHUIS T,et al.Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice[J].Front Immunol,2017,8:1385.
[9] LERNER A,NEIDHÖFER S,MATTHIAS T.The Gut Microbiome Feelings of the Brain:A Perspective for Non-Microbiologists[J].Microorganisms,2017,5(4):66.
[10] LAHTI L,SALOJÄRVI J,SALONEN A,et al.Tipping elements in the human intestinal ecosystem[J].Nat Commun,2014,5:4344.
[11] OHLSSON C,ENGDAHL C,FÄK F,et al.Probiotics protect mice from ovariectomy-induced cortical bone loss[J].PLoS One,2014,9(3):92368.
[12] NOVINCE CM,WHITTOW CR,AARTUN JD,et al.Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health[J].Sci Rep,2017,7(1):5747.
[13] CHUNG HJ,KYUNG KIM W,JOO PARK H,et al.Anti-osteoporotic activity of harpagide by regulation of bone formation in osteoblast cell culture and ovariectomy-induced bone loss mouse models[J].J Ethnopharmacol,2016,179:66-75.
[14] BUCHET R,MILLÁN JL,MAGNE D.Multisystemic functions of alkaline phosphatases[J].Methods Mol Biol,2013,1053:27-51.
[15] CHEN YC,GREENBAUM J,SHEN H,et al.Association Between Gut Microbiota and Bone Health:Potential Mechanisms and Prospective[J].J Clin Endocrinol Metab,2017,102(10):3635-3646.
[16] EJTAHED HS,SOROUSH AR,ANGOORANI P,et al.Gut Microbiota as a Target in the Pathogenesis of Metabolic Disorders:A New Approach to Novel Therapeutic Agents[J].Horm Metab Res,2016,48(6):349-358.
[17] MCCABE L,BRITTON RA,PARAMESWARAN N.Prebiotic and Probiotic Regulation of Bone Health:Role of the Intestine and its Microbiome[J].Curr Osteoporos Rep,2015,13(6):363-371.
[18] KWAN TAT S,PADRINES M,THÉOLEYRE S,et al.IL-6,RANKL,TNF-alpha/IL-1:interrelations in bone resorption pathophysiology[J].Cytokine Growth Factor Rev,2004,15(1):49-60.
[19] KANIS JA,MCCLOSKEY EV,JOHANSSON H,et al.European guidance for the diagnosis and management of osteoporosis in postmenopausal women[J].Osteoporos Int,2013,24(1):23-57.
[20] GÓMEZ NAVARRO R.Use of the FRAX algorithm to calculate the fracture risk in women of a rural area[J].Rev Esp Salud Publica,2010,84(3):321-330.
[21] LEKAMWASAM S,ADACHI JD,AGNUSDEI D,et al.A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis[J].Osteoporos Int,2012,23(9):2257-2276.
[22] 周年,刘波,徐彭.氧化应激与骨质疏松症的研究进展[J].中国骨质疏松杂志,2014,20(12):1485-1489.
[23] 张鲲,陈晓亮.氧化应激与骨质疏松[J].中国骨质疏松杂志,2006,12(5):535-537.
[24] CHAPPLE SJ,PUSZYK WM,MANN GE.Keap1-Nrf2 regulated redox signaling in utero:Priming of disease susceptibility in offspring[J].Free Radic Biol Med,2015,88(Pt B):212-220.
[25] AGARWAL A,APONTE-MELLADO A,PREMKUMAR BJ,et al.The effects of oxidative stress on female reproduction:a review[J].Reprod Biol Endocrinol,2012,10:49.
[26] MANOLAGAS SC.From estrogen-centric to aging and oxidative stress:a revised perspective of the pathogenesis of osteoporosis[J].Endocr Rev,2010,31(3):266-300.
[27] PANSINI F,MOLLICA G,BERGAMINI CM.Management of the menopausal disturbances and oxidative stress[J].Curr Pharm Des,2005,11(16):2063-2073.
[28] LEAN JM,DAVIES JT,FULLER K,et al.A crucial role for thiol antioxidants in estrogen-deficiency bone loss[J].J Clin Invest,2003,112(6):915-923.
[29] MEDEMA RH,KOPS GJ,BOS JL,et al.AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1[J].Nature,2000,404(6779):782-787. 中医正骨2018年3月第30卷第3期 J Trad Chin Orthop Trauma,2018,Vol.30,No.3(总215) (总216)中医正骨2018年3月第30卷第3期 J Trad Chin Orthop Trauma,2018,Vol.30,No.3
[30] TRAN H,BRUNET A,GRENIER JM,et al.DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein[J].Science,2002,296(5567):530-534.
[31] KOPS GJ,DANSEN TB,POLDERMAN PE,et al.Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress[J].Nature,2002,419(6904):316-321.
[32] VILLATE O,TURATSINZE JV,MASCALI LG,et al.Nova1 is a master regulator of alternative splicing in pancreatic beta cells[J].Nucleic Acids Res,2014,42(18):11818-11830.
[33] BRUNET A,BONNI A,ZIGMOND MJ,et al.Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor[J].Cell,1999,96(6):857-868.
[34] POLVANI S,TAROCCHI M,GALLI A.PPARγ and Oxidative Stress:Con(β)Catenating NRF2 and FOXO[J].PPAR Res,2012,2012:641087.
[35] HOOGEBOOM D,ESSERS MA,POLDERMAN PE,et al.Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity[J].J Biol Chem,2008,283(14):9224-9230.
[36] POUYET L,CARRIER A.Mutant mouse models of oxidative stress[J].Transgenic Res,2010,19(2):155-164.
[37] ESSERS MA,DE VRIES-SMITS LM,BARKER N,et al.Functional interaction between beta-catenin and FOXO in oxidative stress signaling[J].Science,2005,308(5725):1181-1184.
[38] HOOGEBOOM D,BURGERING BM.Should I stay or should I go:beta-catenin decides under stress[J].Biochim Biophys Acta,2009,1796(2):63-74.
[39] ALMEIDA M.Unraveling the role of FoxOs in bone—insights from mouse models[J].Bone,2011,49(3):319-327.
[40] ALMEIDA M,HAN L,AMBROGINI E,et al.Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts[J].J Biol Chem,2011,286(52):44326-44335.
[41] OH J,HUR MW,LEE CE.SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis[J].Oncogene,2009,28(35):3145-3156.
[42] KUANG W,ZHENG L,XU X,et al.Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation[J].Bone Res,2017,5:17037.
[43] KIM HK,LEE JS,KIM JH,et al.Bone-forming peptide-2 derived from BMP-7 enhances osteoblast differentiation from multipotent bone marrow stromal cells and bone formation[J].Exp Mol Med,2017,49(5):328.
[44] BALANI DH,ONO N,KRONENBERG HM.Parathyroid hormone regulates fates of murine osteoblast precursors in vivo[J].J Clin Invest,2017,127(9):3327-3338.
[45] VAN DE PEPPEL J,STRINI T,TILBURG J,et al.Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics[J].Stem Cell Reports,2017,8(4):947-960.
[46] ZHOU BO,YU H,YUE R,et al.Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF[J].Nat Cell Biol,2017,19(8):891-903.
[47] WU M,WANG Y,SHAO JZ,et al.Cbfβ governs osteoblast-adipocyte lineage commitment through enhancing β-catenin signaling and suppressing adipogenesis gene expression[J].Proc Natl Acad Sci USA,2017,114(38):10119-10124.
[48] DEBRUINE ZJ,XU HE,MELCHER K.Assembly and architecture of the Wnt/β-catenin signalosome at the membrane[J].Br J Pharmacol,2017,174(24):4564-4574.
[49] DEBRUINE ZJ,KE J,HARIKUMAR KG,et al.Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization[J].Genes Dev,2017,31(9):916-926.
[50] YANG N,LI Y,WANG G,et al.Tumor necrosis factor-α suppresses adipogenic and osteogenic differentiation of human periodontal ligament stem cell by inhibiting miR-21/Spry1 functional axis[J].Differentiation,2017,97:33-43.
[51] ZHANG L,TANG Y,ZHU X,et al.Overexpression of MiR-335-5p Promotes Bone Formation and Regeneration in Mice[J].J Bone Miner Res,2017,32(12):2466-2475.
[52] ANASTASILAKIS AD,POLYZOS SA,MAKRAS P,et al.Circulating semaphorin-4D and plexin-B1 levels in postmenopausal women with low bone mass:the 3-month effect of zoledronic acid,denosumab or teriparatide treatment[J].Expert Opin Ther Targets,2015,19(3):299-306.
[53] ZHANG Y,FENG E,XU Y,et al.Serum Sema4D levels are associated with lumbar spine bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis[J].Int J Clin Exp Med,2015,8(9):16352-16357.
[54] 张韬,陈冬冬,翁艳,等.Sema4D基因沉默对骨髓间充质干细胞成骨及成脂肪分化相关基因表达的影响[J].厦门大学学报(自然科学版),2017,56(2):173-177.
[55] 李冠彗,李灿东,李西海,等.雌激素调控绝经后骨质疏松症骨吸收-骨形成耦联失衡的机制[J].中医正骨,2016,28(2):36-40.

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更新日期/Last Update: 2018-08-02