[1]李明,徐明雄,冯左基,等.自拟壮骨方治疗绝经后骨质疏松症的疗效及作用机制研究[J].中医正骨,2014,26(09):21-24.
　Li Ming*,Xu Mingxiong,Feng Zuoji,et al.Study on the curative effect and mechanism of action of self-made ZHUANGGU decoction in treatment of postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(09):21-24.
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自拟壮骨方治疗绝经后骨质疏松症的疗效及作用机制研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期数:
2014年09期
页码:
21-24
栏目:
临床研究
出版日期:
2014-09-30

文章信息/Info

Title:
Study on the curative effect and mechanism of action of self-made ZHUANGGU decoction in treatment of postmenopausal osteoporosis
作者:
李明; 徐明雄; 冯左基; 胡建强; 郝涛; 贾舜; 祝海滨; 夏文波; 东光彬
山东省青岛市黄岛区中医医院,山东 青岛 266500
Author(s):
Li Ming*; Xu Mingxiong; Feng Zuoji; Hu Jianqiang; Hao Tao; Jia Shun; Zhu Haibin; Xia Wenbo; Dong Guangbin.
*Traditional Chinese Medicine Hospital of Huangdao,Qingdao 266500,Shandong,China
关键词:
骨质疏松; 绝经后 壮骨方 骨密度 雌二醇 治疗; 临床研究性
Keywords:
Osteoporosis; postmenopausal;  ZHUANGGU decoction;  Bone density;  Estradiol;  Therapies; investigational
摘要:
目的:探讨自拟壮骨方治疗绝经后骨质疏松症的疗效及作用机制。方法:将纳入研究的240例绝经后骨质疏松症患者随机分为2组,每组120例。治疗组采用口服自拟壮骨方治疗,对照组采用口服尼尔雌醇片治疗。比较2组患者的骨密度及血清中钙、磷、碱性磷酸酶、雌二醇的水平,同时比较2组患者治疗后的疼痛改善情况。结果:①骨密度。治疗前2组患者腰椎和股骨颈骨密度比较,组间差异均无统计学意义[(0.73±0.26)g·cm-2,(0.71±0.29)g·cm-2,t=3.296,P=0.110;(0.84±0.03)g·cm-2,(0.85±0.02)g·cm-2,t=3.114,P=0.201]。治疗组治疗前后腰椎骨密度的差值大于对照组[(0.20±0.15)g·cm-2,(0.18±0.12)g·cm-2,t=4.012,P=0.021]; 2组患者股骨颈骨密度的差值比较,差异无统计学意义[(0.60±0.24)g·cm-2,(0.16±0.14)g·cm-2,t=1.062,P=0.080]。②血生化指标。治疗前2组患者血清中钙、磷、碱性磷酸酶、雌二醇浓度比较,组间差异均无统计学意义[(2.24±0.16)mmol·L-1,(2.22±0.14)mmol·L-1,t=5.659,P=0.431;(1.19±0.21)mmol·L-1,(1.18±0.22)mmol·L-1,t=3.314,P=0.158;(109.50±13.41)U·L-1,(108.71±20.42)U·L-1,t=1.354,P=0.762;(40.86±18.26)pmol·L-1,(41.14±19.04)pmol·L-1,t=1.918,P=0.656]。治疗组血清中钙和磷浓度治疗前后的差值均大于对照组[(1.61±0.46)mmol·L-1,(0.31±0.25)mmol·L-1,t=5.618,P=0.000;(0.60±0.24)mmol·L-1,(0.30±0.14)mmol·L-1,t=7.012,P=0.000]; 碱性磷酸酶和雌二醇浓度治疗前后的差值与对照组比较,差异均无统计学意义[(20.21±12.16)U·L-1,(16.11±10.12)U·L-1,t=1.368,P=0.612;(19.26±10.23)pmol·L-1,(16.76±9.67)pmol·L-1,t=1.386,P=0.748]。③疼痛改善情况。治疗组显效74例、有效35例、无效11例,对照组显效71例、有效34例、无效15例。治疗结束后2组患者疼痛改善情况比较,差异无统计学意义(Z=-0.547,P=0.584)。结论:自拟壮骨方具有类雌激素样作用,可通过提高雌激素水平,改善骨代谢,增加骨密度,减轻绝经后骨质疏松症患者的疼痛症状。
Abstract:
Objective:To study the curative effect and mechanism of action of self-made ZHUANGGU decoction in treatment of postmenopausal osteoporosis(PMO).Methods:Two hundred and forty patients with PMO were randomly divided into 2 groups,120 cases in each group.The patients in the treatment group was treated with oral application of self-made ZHUANGGU decoction,while others in the control group was treated with nilestriol tablet.Bone mineral density(BMD)and serum level of Ca,P,alkaline phosphatase(ALP)and estradiol(E2)were compared between the 2 groups.Meanwhile,the posttreatment pain degree was compared between the 2 groups.Results:There was no statistical difference in BMD of lumbar spine and femoral neck between the 2 groups before the treatment(0.73+/-0.26 vs 0.71+/-0.29 g/cm(2),t=3.296,P=0.110; 0.84+/-0.03 vs 0.85+/-0.02 g/cm(2),t=3.114,P=0.201).After the treatment,the lumbar spine BMD change of treatment group was greater than that of control group(0.20+/-0.15 vs 0.18+/-0.12 g/cm(2),t=4.012,P=0.021),and there was no statistical difference in the femoral neck BMD change between the 2 groups(0.60+/-0.24 vs 0.16+/-0.14 g/cm(2),t=1.062,P=0.080).There was no statistical difference in serum level of Ca,P,ALP an E2 between the 2 groups before the treatment(2.24+/-0.16 vs 2.22+/-0.14 mmol/L,t=5.659,P=0.431; 1.19+/-0.21 vs 1.18+/-0.22 mmol/L,t=3.314,P=0.158; 109.50+/-13.41 vs 108.71+/-20.42 U/L,t=1.354,P=0.762; 40.86+/-18.26 vs 41.14+/-19.04 pmol·L-1,t=1.918,P=0.656).After the treatmeng,the change of serum level of Ca and P of treatment group was greater than that of control group(1.61+/-0.46 vs 0.31+/-0.25 mmol/L,t=5.618,P=0.000; 0.60+/-0.24 vs 0.30+/-0.14 mmol/L,t=7.012,P=0.000),while there was no statistical difference in the change of serum level of ALP and E2 between the 2 groups(20.21+/-12.16 vs 16.11+/-10.12 U/L,t=1.368,P=0.612; 19.26+/-10.23 vs 16.76+/-9.67 pmol/L,t=1.386,P=0.748).Seventy-four patients obtained an excellent result,35 good and 11 poor in the treatment group; while 71 patients obtained an excellent result,34 good and 15 poor in the control group.There was no statistical difference in the degree of pain relief between 2 groups after the treatment(Z=-0.547,P=0.584).Conclusion:Self-made ZHUANGGU decoction has estrogen-like effects,so it can effectively reduce the pain symptoms of the patients with PMO through increasing estrogen levels and improving bone metabolism and increasing BMD.

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更新日期/Last Update: 2014-09-30