参考文献/References:
[1] 胡炯,王博,吴鹏,等.CKIP-1与骨质疏松的最新研究进展[J].中国骨质疏松杂志,2016,22(8):1053-1057.
[2] NIE J,LIU L,XING G,et al.CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation[J].Oncogene,2014,33(28):3677-3687.
[3] TOKUDA E,FUJITA N,OH-HARA T,et al.Casein kinase 2-interacting protein-1,a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo[J].Cancer Res,2007,67(20):9666-9676.
[4] FLORENCIO-SILVA R,DA SILVA SASSO GR,SIMOES MJ,et al.Biology of bone tissue:structure,function,and factors that influence bone cells[J].Biomed Res Int,2015,10(1155):421746-421763.
[5] HOSOKAWA N,HARA T,KAIZUKA T,et al.Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy[J].Mol Biol Cell,2009,20(7):1981-1991.
[6] DIBBLE CC,MANNING BD.Signal integration by mTORC1 coordinates nutrient input with biosynthetic output[J].Nat Cell Biol,2013,15(6):555-564.
[7] HE C,KLIONSKY DJ.Regulation mechanisms and signaling pathways of autophagy[J].Annu Rev Genet,2009,43:67-93.
[8] GANLEY IG,LAM DU H,WANG J,et al.ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy[J].J Biol Chem,2009,284(18):12297-12305.
[9] HOSOKAWA N,SASAKI T,IEMURA SI,et al.Atg101,a novel mammalian autophagy protein interacting with Atg13[J].Autophagy,2009,5(7):973-979.
[10] JUNG HS,CHUNG KW,WON KIM J,et al.Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia[J].Cell Metab,2008,8(4):318-324.
[11] LIU F,FANG F,YUAN H,et al.Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation[J].J Bone Miner Res,2013,28(11):2414-2430.
[12] NOLLET M,SANTUCCI-DARMANIN S,BREUIL V,et al.Autophagy in osteoblasts is involved in mineralization and bone homeostasis[J].Autophagy,2014,10(11):1965-1977.
[13] NIE J,LIU L,HE FC,et al.CKIP-1: A scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions[J].Ageing Res Rev,2013,12(1,213):276-281.
[14] ZAHM AM,BOHENSKY J,ADAMS CS,et al.Bone cell autophagy is regulated by environmental factors[J].Cells Tissues Organs,2011,194(2/4):274-278.
[15] KING JS,VELTMAN DM,INSALL RH.The induction of autophagy by mechanical stress[J].Autophagy,2011,7(12):1490-1499.
[16] JIA J,YAO W,GUAN M,et al.Glucocorticoid dose determines osteocyte cell fate[J].FASEB J,2011,25(10):3366-3376.
[17] DESELM CJ,MILLER BC,ZOU W,et al.Autophagy proteins regulate the secretory component of osteoclastic bone resorption[J].Dev Cell,2011,21(5):966-974.
[18] CEJKA D,HAYER S,NIEDERREITER B,et al.Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis[J].Arthritis Rheum,2010,62(8):2294-2302.
[19] ZHAO Y,CHEN G,ZHANG W,et al.Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1α/BNIP3 signaling pathway[J].J Cell Physiol,2012,227(2):639-648.
[20] SAMBANDAM Y,TOWNSEND MT,PIERCE JJ,et al.Microgravity control of autophagy modulates osteoclastogenesis[J].Bone,2014,61:125-131.
[21] SHI J,WANG L,ZHANG H,et al.Glucocorticoids: dose-related effects on osteoclast formation and function via reactive Oxygen species and autophagy[J].Bone,2015,79:222-232.
[22] GLANTSCHNIG H,FISHER JE,WESOLOWSKI G,et al.M-CSF,TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase[J].Cell Death Differ,2003,10(10):1165–1177.
[23] ERNST M,HEATH JK,SCHMID C,et al.Evidence for a direct effect of estrogen on bone cells in vitro[J].J Steroid Biochem,1989,34(1-6):279-284.
[24] YANG YH,CHEN K,LI B,et al.Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER-ERK-mTOR pathway[J].Apoptosis,2013,18(11):1363-1375.
[25] TCHETINA EV,MASLOVA KA,KRYLOV MY,et al.Association of bone loss with the upregulation of survival-related genes and concomitant downregulation of Mammalian target of rapamycin and osteoblast differentiation-related genes in the peripheral blood of late postmenopausal osteoporotic women[J].J Osteoporos,2015
[2017-10-11].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338391.
[26] KNEISSEL M,LUONG-NGUYEN NH,BAPTIST M,et al.Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts[J].Bone,2004,35(5):1144-1156.
[27] CHUNG YH,YOON SY,CHOI B,et al.Microtubule-associated protein light chain 3 regulates Cdc42-dependent actin ring formation in osteoclast[J].Int J Biochem Cell Biol,2012,44(6):989-997.
[28] PRIETO-DOMÍNGUEZ N,ORDÓÑEZ R,FERNNDEZ A,et al.Modulation of autophagy by sorafenib:effects on treatment response[J].Front Pharmacol,2016,7:151.
相似文献/References:
[1]李林军.应用膨胀式椎弓根螺钉内固定治疗合并骨质疏松的
胸腰椎退行性疾病[J].中医正骨,2015,27(08):49.
[2]李学朋,朱立国.骨疏康胶囊对去卵巢大鼠骨小梁的影响[J].中医正骨,2015,27(12):12.
LI Xuepeng,ZHU Liguo.Effect of Gushukang Jiaonang(骨疏康胶囊)on bone trabecula in the ovariectomized rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(04):12.
[3]陈冠军,陈扬,庄汝杰.可灌注骨水泥椎弓根螺钉系统
在老年腰椎疾患手术中的应用[J].中医正骨,2015,27(02):40.
[4]王丹辉,贲越,韩梅.林蛙油治疗绝经后骨质疏松症的临床研究[J].中医正骨,2014,26(01):27.
Wang Danhui*,Ben Yue,Han Mei..Clinical study of Rana temporaria oil in the treatment of postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(04):27.
[5]黄建华,黄建武,李慧辉,等.加味左归丸对绝经后骨质疏松症肝肾不足证
患者骨密度的影响[J].中医正骨,2013,25(11):19.
Huang Jianhua*,Huang Jianwu,Li Huihui,et al.Effect of JIAWEI ZUOGUI pill on bone mineral density in postmenopausal osteoporosis patients with deficiency of liver and kidney[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(04):19.
[6]项旻,杨虹,林爱菊,等.绝经后2型糖尿病患者骨质疏松与血微量元素的关系研究[J].中医正骨,2013,25(12):20.
Xiang Min*,Yang Hong,Lin Aiju,et al.Clinical study on the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(04):20.
[7]史晓林,李春雯,张志强.弱阳离子磁珠分离技术和基质辅助激光解吸电离飞行时间质谱技术在原发性Ⅰ型骨质疏松症血清标志蛋白筛选中的应用[J].中医正骨,2014,26(03):5.
Shi Xiaolin*,Li Chunwen,Zhang Zhiqiang..Application of magnetic beads based weak cation exchange separation technology and matrix-assisted laser desorption-ionization time of flight mass spectrometry technology in screening serum protein markers of primary type-Ⅰ osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(04):5.
[8]李明,徐明雄,冯左基,等.自拟壮骨方治疗绝经后骨质疏松症的疗效及作用机制研究[J].中医正骨,2014,26(09):21.
Li Ming*,Xu Mingxiong,Feng Zuoji,et al.Study on the curative effect and mechanism of action of self-made ZHUANGGU decoction in treatment of postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(04):21.
[9]陈俊杰,李晴晴,夏瑢.脂代谢及血清内脂素水平与绝经后骨质疏松症的
相关性研究[J].中医正骨,2012,24(04):16.
CHEN Jun-jie*,LI Qing-qing,XIA Rong.*.Study on the correlations between the levels of lipid metabolism and serum visfatin and postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(04):16.
[10]许超,肖鲁伟,吴承亮.绝经后女性骨质疏松症辨证分型与抑郁焦虑的关系研究[J].中医正骨,2011,23(12):3.
XU Chao*,XIAO Lu-wei,WU Cheng-liang.*.Study on the relationship between the syndrome differ classification and the depression and anxiety for the postmenopausal women with osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(04):3.
[11]韩艳,温利平,刘娜,等.补肾活血方对去卵巢大鼠骨代谢及骨密度的影响[J].中医正骨,2015,27(12):7.
HAN Yan,WEN Liping,LIU Na,et al.Effect of Bushen Huoxue Fang(补肾活血方)on bone metabolism and bone mineral density in the ovariectomized rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(04):7.
[12]欧国峰,刘鑫,董博,等.绝经后骨质疏松症的免疫学研究进展[J].中医正骨,2016,28(08):70.
[13]施振宇,刘钟,陈文亮,等.中医综合疗法防治绝经后骨量减少的多中心临床研究[J].中医正骨,2017,29(04):1.
SHI Zhenyu,LIU Zhong,CHEN Wenliang,et al.A multicenter clinical study of complex therapy of traditional Chinese medicine for prevention and treatment of postmenopausal osteopenia[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2017,29(04):1.
[14]梁文娜,李西海,李灿东.血清microRNA与绝经后骨质疏松症肾虚证的关系[J].中医正骨,2017,29(10):53.
[15]梁文娜,李西海,胡柳,等.二至丸抑制绝经后骨质疏松大鼠骨代谢紊乱的作用机制研究[J].中医正骨,2017,29(11):1.
LIANG Wenna,LI Xihai,HU Liu,et al.Study on mechanism of action of Erzhi Wan(二至丸)in inhibiting bone metabolism disorder in rats with postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2017,29(04):1.
[16]刘晨,李兴勇,姚兴璋,等.绝经后骨质疏松症的流行病学概况及发病机制研究进展[J].中医正骨,2018,30(03):52.
[17]曹俊青,郑剑南,张麟.右归丸联合阿仑膦酸钠口服治疗绝经后骨质疏松症肾阳虚证的临床研究[J].中医正骨,2018,30(05):20.
CAO Junqing,ZHENG Jiannan,ZHANG Lin.A clinical study of oral application of Yougui Wan(右归丸)and alendronate sodium for treatment of postmenopausal osteoporosis with kidney-yang deficiency syndrome[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(04):20.
[18]李中万,徐绍俊,杨广钢,等.健肾方联合碳酸钙D3咀嚼片(Ⅱ)
治疗绝经后骨质疏松症肾阳虚证[J].中医正骨,2018,30(08):11.
LI Zhongwan,XU Shaojun,YANG Guanggang,et al.Oral application of Jianshen Fang(健肾方)and calcium carbonate and Vitamin D3 chewable tablets(Ⅱ)for treatment of postmenopausal osteoporosis with kidney-yang deficiency syndrome[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(04):11.
[19]赵凡,刘全,吴连国.口服强骨饮联合碳酸钙D3片治疗绝经后骨质疏松症的临床研究[J].中医正骨,2019,31(04):26.
ZHAO Fan,LIU Quan,WU Lianguo.Oral applications of Qianggu Yin(强骨饮)and calcium carbonate and Vitamin D3 tablets for treatment of postmenopausal osteoporosis:a clinical study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(04):26.
[20]史晓林,杨依然,刘钟,等.基于蛋白质组学方法分析绝经后骨质疏松症全血差异蛋白[J].中医正骨,2019,31(06):7.
SHI Xiaolin,YANG Yiran,LIU Zhong,et al.Analysis of proteins which are differentially expressed in whole blood of patients with postmenopausal osteoporosis using proteomics approach[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(04):7.