参考文献/References:
[1] 周婧,侯幸赟,刘婷婷,等.地舒单抗治疗骨折高风险绝经后骨质疏松症的疗效评价[J].中国临床医学,2025,32(1):85-92.
[2] 李锡,杨立英,张永旺,等.三种中医理筋正骨手法治疗膝骨关节炎随机对照研究[J].中国中西医结合杂志,2024,44(11):1307-1313.
[3] 崔鑫,李永耀,孟宇航,等.绝经后骨质疏松症与膝骨关节炎共病的中西医病机及精准论治思考[J/OL].世界中医药[2025-03-20].https://link.cnki.net/urlid/11.5529.R.20250305.1926.056.
[4] 刘科第,陈勇喜,郭圣挥,等.中药复方治疗肝肾阴虚型绝经后骨质疏松症的疗效及机制进展[J].壮瑶药研究,2023(3):382-384.
[5] 严菊芳,陈纯,袁丽.通络止痛方治疗膝骨关节炎的效果及其对炎症因子影响[J].中国中西医结合外科杂志,2025,31(2):202-207.
[6] 李博,张师侥,张江,等.基于“脾肾相关”理论论治膝骨性关节炎合并骨质疏松症[J].实用中医内科杂志,2025,39(3):57-60.
[7] 杨浩宇,王世坤,杨东元,等.补肾活血中药治疗膝骨性关节炎与骨质疏松症“共病”机制研究进展[J].中草药,2024,55(11):3898-3905.
[8] 杨欢,赵敏,肖璟.海桐皮汤联合依降钙素对绝经后骨质疏松合并膝骨关节炎患者IL-1β、OPN和MMP-13及其抑制因子表达的影响[J].湖北中医杂志,2021,43(9):3-7.
[9] 郭荪林,洪恩达,戴新华,等.补肾健脾方对去势模型大鼠骨代谢及骨微结构的影响[J].中国组织工程研究,2025,29(26):5588-5594.
[10] 沈锦涛,华茂奇,张北,等.基于Akt/Nrf2/GPX4信号通路探究养血柔筋方含药血清对IL-1β致大鼠退变软骨细胞铁死亡的影响[J].中药材,2024,47(7):1793-1799.
[11] 胡雪琴,金红婷,肖鲁伟,等.“浙派中医”骨伤学家肖鲁伟辨治“髓系骨病”的学术经验[J].浙江中医药大学学报,2019,43(10):1071-1073.
[12] 汪小健,李少广,王彭禾,等.基于“髓系骨病”理论论治膝骨关节炎[J].中华中医药杂志,2021,36(11):6500-6503.
[13] 胡雪琴,金红婷,施振宇,等.髓病理论及其在骨病学中的应用[J].中医正骨,2018,30(11):39-42.
[14] 王鼎珍,许云腾,黄祖儿,等.从脂-骨代谢紊乱探讨绝经后骨质疏松症的形成机制[J].中国医学创新,2025,22(7):151-154.
[15] 叶倩云,朱晓峰,韩莉,等.基于经筋理论浅析退行性骨关节病[J].中华中医药杂志,2020,35(9):4587-4589.
[16] 杜凯月.绝经后女性雌二醇水平与膝骨关节炎的相关性研究[D].济南:济南大学,2018.
[17] 于冬冬,赵丹阳,杨芳,等.中药复方鹿角胶丸防治绝经后骨质疏松症的机制研究[J].中国骨质疏松杂志,2020,26(11):1668-1673.
[18] 伍海艳,吴荣艳,钟凤元,等.雌激素代谢紊乱对老年女性骨质疏松患者的影响[J].中国老年学杂志,2021,41(12):2567-2569.
[19] 刘鲁冰,刘雪环,李媛.机械敏感性离子通道Piezo1的生理作用[J].生理科学进展,2024,55(2):155-162.
[20] 刘建军,陈欣,李元贞,等.藁本内酯防治股骨头坏死的分子学机制探讨[J].风湿病与关节炎,2022,11(1):47-51.
[21] 董子杰,浦飞飞,张慧浩,等.氧化应激反应在骨质疏松高危人群中的作用及机制研究进展[J].骨科,2025,16(1):86-90.
[22] 黄俊,崔露,黄志灿,等.近10年艾灸治疗膝关节骨关节炎的机制研究进展[J].针刺研究,2025,50(7):834-843.
[23] 沈波,杨鸫祥,那俊夫,等.基于“肠道菌群”探讨从脾肾论治原发性骨质疏松症科学内涵[J].辽宁中医药大学学报,2022,24(4):201-205.
[24] 金芳全,樊成虎,唐晓栋,等.续断提取物对骨质疏松性大鼠信号通路作用的研究进展[J].中国骨质疏松杂志,2023,29(7):1016-1020.
[25] ZHANG Z,YUAN D,JIN X,et al.Asperosaponin VI suppresses ferroptosis in chondrocytes and ameliorates osteoarthritis by modulating the Nrf2/GPX4/HO-1 signaling pathway[J].Front Pharmacol,2025,16:1539092.
[26] 庞庆彩,杨发奋,谭军华.Runx2对肾性骨病的影响研究进展[J].右江医学,2024,52(10):940-944.
[27] 郭晓彤,宋俊丽,韦秋,等.菟丝子丸调控BMP2/RUNX2信号通路抗绝经后骨质疏松研究[J].天津中医药,2024,41(12):1599-1604.
[28] ZOU J,PENG Y,WANG Y,et al.Icariin ameliorates osteoporosis by activating autophagy in ovariectomized rats[J].Adv Clin Exp Med,2024,33(9):941-952.
[29] FENG R,WANG Q,YU T,et al.Quercetin ameliorates bone loss in OVX rats by modulating the intestinal flora-SCFAs-inflammatory signaling axis[J].Int Immunopharmacol,2024,136:112341.
[30] 陈楠,李晓莉,张岩.女贞子及其活性成分抗骨质疏松作用及途径研究进展[J].中国药理学通报,2018,34(8):1057-1060.
[31] 陈春雯,严波,单乐天,等.女贞子提取物干预大鼠膝骨关节炎的实验研究[J].中国中医急症,2020,29(4):579-583.
[32] PANG W,WANG X,MOK S,et al.Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like(UMR-106)cells[J].Br J Pharmacol,2010,159(8):1693-1703.
[33] 莫亚峰,周坤,王徐刚,等.β-蜕皮甾酮通过调控β-catenin/BMP表达促进骨髓间充质干细胞分化治疗骨质疏松性骨折的作用机制[J].浙江临床医学,2022,24(9):1275-1278.
[34] 梁桂芳,何智军,林知毅,等.山茱萸通过转化生长因子-β通路改善去卵巢大鼠骨质疏松症[J].中国中医骨伤科杂志,2025,33(2):1-7.
[35] 李虎业,窦增花,孔德元,等.山茱萸新苷Ⅰ干预膝骨关节炎模型大鼠抑制白细胞介素6介导的炎性反应[J].中国组织工程研究,2021,25(2):211-215.
[36] 李明,李君,付昆.骨碎补总黄酮对膝骨关节炎模型兔HIF-1α和VEGF表达的影响[J].中国药房,2018,29(18):2484-2488.
[37] 李紫莎,韩白杨,沈凯,等.膝骨关节炎中西医治疗的研究进展[J].中外医学研究,2025,23(4):173-176.
[38] GUREVICH D B,DAVID D T,SUNDARARAMAN A,et al.Endothelial heterogeneity in development and wound healing[J].Cells,2021,10(9):2338.
[39] 程韶,杨骏杰,王晶,等.齐墩果酸局部给药对去卵巢小鼠骨折愈合的影响[J].中国骨质疏松杂志,2021,27(12):1717-1725.
[40] 周天宇,谢佑红,王姜俨,等.刺五加苷E对去卵巢小鼠骨量及神经肽的影响[J].中国骨质疏松杂志,2023,29(5):655-659.
[41] 张小锋,蒋涛,卞胡伟,等.鹿茸主要活性成分防治骨质疏松症的分子机制研究[J].中国骨质疏松杂志,2023,29(6):897-901.
[42] 修忠标,江陟郝,孙磊.鹿茸多肽干预膝骨性关节炎软骨细胞的增殖[J].中国组织工程研究与临床康复,2011,15(24):4448-4452.
[43] 东智卓玛,杨彬彬,林适,等.壮骨强肌方对去势大鼠骨密度及IL-17的影响[J].中国骨质疏松杂志,2024,30(1):62-69.
[44] 王静雅,闫康,李继安,等.益肾逐瘀通络汤对膝骨关节炎大鼠软骨细胞焦亡和铁死亡的影响[J].中国比较医学杂志,2025,35(1):49-58.
[45] 王嘉玉,颜春鲁,安方玉,等.基于Th17/Treg平衡探讨骨质疏松症研究进展[J].中国免疫学杂志,2024,40(6):1283-1291.
[46] 卢月,曹雅晶,钱瑞琴.IL-17在类风湿性关节炎发病机制中的作用[J].中国免疫学杂志,2011,27(9):855-859.
[47] 陈景涛,陈有,李玉静,等.黄芪多糖抑制Toll样受体4/核因子κBp65通路治疗大鼠膝骨关节炎[J].中国组织工程研究,2023,27(31):5002-5008.
[48] 史桂荣,任博文,张仲博,等.黄芪多糖干预对骨关节炎模型小鼠关节软骨损伤的修复[J].中国组织工程研究,2022,26(20):3236-3242.
[49] 王诗婷,孔伟华,温乐乐,等.中药三萜类成分防治膝骨关节炎作用机制研究进展[J].中草药,2023,54(18):6128-6138.
[50] 姚志城.基于P2X7R/NLRP3信号通路探讨牛膝提取物治疗膝骨关节炎的机制研究[D].广州:广州中医药大学,2024.
[51] 张旭,倪秀一,李智,等.红芪抗骨质疏松药理作用及机制研究进展[J].药物评价研究,2025,48(2):307-316.
[52] 翟鑫祥,董辉,王晶,等.黄芪多糖保护去卵巢大鼠成骨细胞功能活性的机制研究[J].天津医药,2022,50(3):265-269.
[53] WANG H,ZHAO X,WU Z.Mechanism of drug-pairs astragalus mongholicus-largehead atractylodes on treating knee osteoarthritis investigated by GEO gene chip with network pharmacology and molecular docking[J].Medicine(Baltimore),2024,103(27):e38699.
[54] ZHANG J,FAN F,LIU A,et al.Icariin:a potential molecule for treatment of knee osteoarthritis[J].Front Pharmacol,2022,13:811808.
[55] 李远栋,王世坤,杨东元,等.淫羊藿苷防治膝骨性关节炎作用机制的研究进展[J].中草药,2023,54(8):2652-2658.
[56] 康庐琛,魏秋实,李文斌,等.槲皮素调控MAPK通路对绝经后骨质疏松大鼠骨形成的影响[J].中国骨质疏松杂志,2024,30(5):625-630.
[57] BAO J,YAN W,XU K,et al.Oleanolic acid decreases IL-1β-induced activation of fibroblast-like synoviocytes via the SIRT3-NF-κB axis in osteoarthritis[J].Oxid Med Cell Longev,2020,2020:7517219.
[58] 赵素霞,刘会丽,江红.菟丝子黄酮通过调节Wnt/β-catenin信号通路干预去卵巢大鼠骨代谢的机制研究[J].临床和实验医学杂志,2018,17(1):25-28.
[59] 刘映岐.菟丝子治疗膝骨性关节炎实验及临床验证研究[D].成都:成都中医药大学,2017.
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[17]杨依然,刘钟,毛一凡,等.酪蛋白激酶-2相互作用蛋白1基于磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白通路参与绝经后骨质疏松症发生发展过程中细胞自噬的机制[J].中医正骨,2018,30(04):59.
[18]曹俊青,郑剑南,张麟.右归丸联合阿仑膦酸钠口服治疗绝经后骨质疏松症肾阳虚证的临床研究[J].中医正骨,2018,30(05):20.
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