[1]王一迪,范利娟,石洋,等.基于数据挖掘的中药内服治疗腰椎间盘突出症术后残留症状用药规律研究[J].中医正骨,2023,35(08):37-42.
　WANG Yidi,FAN Lijuan,SHI Yang,et al.A data mining-based analysis of clinical medication rules of oral Chinese herbal medicine prescriptions for treatment of residual symptoms after surgery for lumbar disc herniation[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(08):37-42.
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基于数据挖掘的中药内服治疗腰椎间盘突出症术后残留症状用药规律研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年08期
页码:
37-42
栏目:
文献研究
出版日期:
2023-08-20

文章信息/Info

Title:
A data mining-based analysis of clinical medication rules of oral Chinese herbal medicine prescriptions for treatment of residual symptoms after surgery for lumbar disc herniation
作者:
王一迪1; 范利娟1; 石洋1; 白超楠1; 崔宏勋2
1.河南中医药大学研究生院,河南 郑州 450046; 2.河南省洛阳正骨医院/河南省骨科医院,河南 郑州 450016
Author(s):
WANG Yidi1; FAN Lijuan1; SHI Yang1; BAI Chaonan1; CUI Hongxun2
1.Postgraduate College of Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China 2.Luoyang Orthopedic-Traumatological Hospital,Zhengzhou 450016,Henan,China
关键词:
椎间盘移位;  腰椎;  手术后并发症;  中药;  方剂分析; 计算机辅助;  数据挖掘
Keywords:
intervertebral disc displacement;  lumbar vertebrae;  postoperative complications;  Traditional Chinese Drugs;  formula analysis; computer assisted;  data mining
摘要:
目的:探讨中药内服治疗腰椎间盘突出症术后残留症状的用药规律。方法:利用计算机检索中国知网、万方数据库、维普网、PubMed、Web of Science中有关中药内服治疗腰椎间盘突出症术后残留症状的文献,检索时限均为建库至2023年1月31日。提取入选文献中的内服方剂,统计方剂的主治证型、药物组成,以及药物的功效、性、味、归经。采用Microsoft Excel 2021软件统计药物的主治证型、出现频次,以及药物的功效、性、味、归经分布情况。采用SPSS Modeler 18.0软件对筛选出的高频药物进行关联规则分析,采用SPSS Statistics 21.0软件对筛选出的高频药物进行聚类分析。结果:纳入研究的文献共117篇,包含123首内服方剂。方剂的主治证型主要有4个,其中气滞血瘀证(42次)、肾虚血瘀证(35次)、肝肾亏虚证(23次)的出现频次较高。123首内服方剂涉及183味中药,累计出现1363次,其中出现频次≥20的药物共20味,排在前3位的依次为当归(82次)、甘草(70次)、牛膝(66次)。药物功效统计结果显示,补虚药(453次)、活血化瘀药(378次)、祛风湿药(147次)的出现频次较高。药性统计结果显示,温性药(664次)、平性药(397次)的出现频次较高。药味统计结果显示,甘味药(746次)、苦味药(624次)、辛味药(592次)的出现频次较高。药物归经统计结果显示,归肝经(900次)、脾经(599次)、肾经(438次)的药物出现频次较高。将出现频次≥20的中药作为高频药物,通过关联规则分析得到11条关联规则,其中前3位依次为川芎→当归、黄芪→当归、红花→当归; 涉及7个核心药物,主要为补虚药(黄芪、当归、甘草)和活血化瘀药(红花、川芎、赤芍、桃仁); 通过聚类分析,得到4类药物组合。结论:中药内服治疗腰椎间盘突出症术后残留症状的用药规律为,以补虚药为主,辅以活血化瘀药; 多用药性温、平,药味甘、苦、辛,归肝经、脾经、肾经的药物; 多以黄芪、当归、甘草、红花、川芎、赤芍、桃仁为主药进行加减。
Abstract:
Objective:To excavate the clinical medication rules of oral Chinese herbal medicine(CHM)prescriptions in treatment of residual symptoms after surgery for lumbar disc herniation(LDH).Methods:All articles about oral CHM prescriptions for treatment of residual symptoms emerged after surgery for LDH included from database establishing to January 31,2023 were retrieved from the China National Knowledge Internet,Wanfang Database,Vip Database,PubMed and Web of Science through computer.The obtained articles were screened according to the predefined inclusion and exclusion criteria,and the oral CHM prescriptions were extracted from the included articles,followed by statistics on the indications,ingredients contained in the CHM prescriptions as well as the efficacy,medicinal property,medicinal flavor and meridian tropism of each Chinese herbs(CHs)in prescriptions.The normalized and standardized CHs in the extracted prescriptions were input into the Microsoft Office Excel 2021 software for building a database,based on which their indications,occurrence frequency,efficacy,medicinal property,medicinal flavor and meridian tropism were statistically analyzed.The high-frequency CHs were then subjected to association rule analysis by using SPSS Modeler 18.0 software and cluster analysis by using SPSS Statistics 21.0 software.Results:One hundred and seventeen articles were included in the final analysis,involving 123 oral CHM prescriptions,and they mainly acted on 4 indications,among which Qi-stagnation and blood-stasis syndrome(42 times),kidney-deficiency and blood-stagnation syndrome(35 times)and liver-kidney deficiency syndrome(23 times)occurred more frequently.One hundred and eighty-three CHs(appeared 1363 times)were involved in the 123 oral CHM prescriptions,among which 20 ones displayed a occurrence frequency of≥20,and the top 3 ones with high occurrence frequency included Angelicae Sinensis Radix(TCD)(82 times),Glycyrrhizae Radix et Rhizoma(TCD)(70 times)and Achyranthes Bidentatae Radix(TCD)(66 times).The results of statistics on efficacy showed that the CHs with high occurrence frequency included reinforcing deficiency herbs(453 times),promoting blood circulation and removing blood stasis herbs(378 times)and dispelling pathogenic wind and dampeness herbs(147 times).The results of statistics on medicinal property showed that the most frequently used CHs were those with a warm property(664 times),followed by the ones with a neutral property(397 times).The results of statistics on medicinal flavor showed that the CHs with sweet,bitter and pungent flavors were more preferred,with their occurrence frequency of being 746,624 and 592 times respectively.The results of statistics on meridian tropism showed that the CHs mainly acted on the liver meridians(900 times),spleen meridians(599 times)and kidney meridians(438 times).The CHs with occurrence frequency of≥20 were considered as the high frequency herbs.Eleven association rules were obtained through association rule analysis,among which the top 3 ones included Chuanxiong Rhizoma→Angelicae Sinensis Radix(TCD),Astmgali Radix(TCD)→Angelicae Sinensis Radix(TCD)and Carthami Flos(TCD)→Angelicae Sinensis Radix(TCD).The association rule analysis on the high frequency herbs involved 7 core herbs,which were mainly the reinforcing deficiency herbs(Astmgali Radix(TCD),Angelicae Sinensis Radix(TCD),Glycyrrhizae Radix et Rhizoma(TCD))as well as the promoting blood circulation and removing blood stasis herbs(Carthami Flos(TCD),Chuanxiong Rhizoma,Paeoniae Radix Rubra,Persicae Semen).Furthermore,4 new herb combinations were obtained by cluster analysis on the high frequency herbs.Conclusion:The oral CHM prescriptions aimed at treating residual symptoms after surgery for LDH are centred on the reinforcing deficiency herbs,supplemented by the promoting blood circulation and removing blood stasis herbs,and the CHs in oral CHM prescriptions are often the ones presented with warm and neutral properties,sweet,bitter and pungent flavors and mainly act on liver,spleen and kidney meridians.Astmgali Radix(TCD),Angelicae Sinensis Radix(TCD),Glycyrrhizae Radix et Rhizoma(TCD),Carthami Flos(TCD),Chuanxiong Rhizoma,Paeoniae Radix Rubra and Persicae Semen are usually used as the core of the oral CHM prescriptions.

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备注/Memo

备注/Memo:
基金项目:全国中医药创新骨干人才项目(国中医药人教函〔2019〕128号); 河南省中医药拔尖人才项目(豫中医科教〔2018〕25号) 通讯作者:崔宏勋 E-mail:chx6542@126.com
更新日期/Last Update: 1900-01-01