[1]马斌祥,屈红,张云飞,等.基于国家专利数据库的腰椎间盘突出症内服中药复方用药规律研究[J].中医正骨,2022,34(05):28-31.
　MA Binxiang,QU Hong,ZHANG Yunfei,et al.A study of clinical medication rules of oral TCM compounds for treatment of lumbar disc herniation based on national patent database[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2022,34(05):28-31.
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基于国家专利数据库的腰椎间盘突出症内服中药复方用药规律研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期数:
2022年05期
页码:
28-31
栏目:
数据库研究
出版日期:
2022-05-20

文章信息/Info

Title:
A study of clinical medication rules of oral TCM compounds for treatment of lumbar disc herniation based on national patent database
作者:
马斌祥1; 屈红1; 张云飞1; 张洋2; 邓梦2; 邓强1
(1.甘肃省中医院,甘肃 兰州 730050; 2.甘肃中医药大学,甘肃 兰州 730000)
Author(s):
MA Binxiang1; QU Hong1; ZHANG Yunfei1; ZHANG Yang2; DENG Meng2; DENG Qiang1
1.Gansu Provincial Hospital of TCM,Lanzhou 730050,Gansu,China 2.Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China
关键词:
椎间盘移位;  腰椎;  方剂分析; 计算机辅助;  数据挖掘
Keywords:
intervertebral disc displacement;  lumbar vertebrae;  formula anal; comput assist;  data mining
摘要:
目的:基于国家专利数据库探讨治疗腰椎间盘突出症的内服中药复方的用药规律。方法:从国家专利数据库筛选治疗腰椎间盘突出症的内服中药复方专利。提取数据后,采用中医传承辅助系统(V2.5)中的“数据分析”模块,进行用药频次统计和组方规律分析。结果:①用药频次统计结果。共筛选到207项治疗腰椎间盘突出症的内服中药复方专利,专利发表时间为2002年7月至2021年4月。纳入的207项中药复方专利共涉及207首中药复方、225味中药。出现频次≥30的中药共34味,其中当归、牛膝、杜仲出现频次较高。药性统计结果显示,温性药、平性药、寒性药出现频次较高。药味统计结果显示,辛味药、苦味药、甘味药出现频次较高。药物归经统计结果显示,归肝经、肾经、脾经、心经的药物出现频次较高。②组方规律分析结果。基于关联规则的组方规律分析结果显示,“牛膝-当归”“牛膝-杜仲”“杜仲-当归”等药对出现频次较高,“牛膝-杜仲-当归”“没药-乳香-当归”“牛膝-当归-独活”等角药出现频次较高; 共得到7条关联规则,分别为“乳香、当归→没药”“乳香→没药”“乳香、牛膝→没药”“没药、杜仲→乳香”“没药、牛膝→乳香”“牛膝、续断→杜仲”“红花、乳香→没药”。基于复杂网络的组方规律分析结果显示,牛膝、杜仲、当归为核心药物。结论:国家专利数据库中治疗腰椎间盘突出症的内服中药复方多以当归、牛膝、杜仲、独活、没药、乳香为核心进行加减,所用药物多性温、平、寒,味辛、苦、甘,归肝、肾、脾、心经。
Abstract:
Objective:To explore the clinical medication rules of oral TCM compounds for treatment of lumbar disc herniation(LDH)based on national patent database.Methods:All authorized patents about oral TCM compounds for treatment of LDH were retrieved from the website of China Patent Announcement of China National Intellectual Property Administration through computer.The obtained patents were screened,and the oral TCM compounds involved in the patents were extracted and their names were standardized and input into Microsoft Office Excel 2019 software to build the database.The analysis on property,flavour,meridian distribution and usage frequency of the Chinese herbs(CHs)in compounds were conducted for excavating clinical medication rules by using data analysis module in TCM inheritance support system(TCMISS)software(V2.5).Results:①Two hundred and seven patents published from July 2002 to April 2021 were screened out,involving 207 TCM compounds and 225 CHs,among which 34 ones displayed a occurrence frequency of≥30,and the ones with high occurrence frequency included Angelica Sinensis,Achyranthes Bidentatae Radix(TCD)and Eucommiae Cortex.The results of statistics on medicinal property showed that the most frequently used CHs were those with a warm property,followed by the ones with a neutral property and a cold property.The results of statistics on medicinal flavor showed that the CHs with pungent,bitter and sweet flavors were more preferred.The results of statistics on meridian tropism showed that the CHs mainly acted on the liver meridians,kidney meridians,spleen meridians and heart meridians.②The results of analysis on association rules-based prescription rules showed that the paired-herbs with high occurrence frequency included Achyranthes Bidentatae Radix(TCD)-Angelica Sinensis,Achyranthes Bidentatae Radix(TCD)-Eucommiae Cortex and Eucommiae Cortex-Angelica Sinensis; and the triplet-herbs with high occurrence frequency included Achyranthes Bidentatae Radix(TCD)-Eucommiae Cortex-Angelica Sinensis,Myrrha-Frankincense-Angelica Sinensis and Achyranthes Bidentatae Radix(TCD)-Angelica Sinensis-Angelicae Pubescentis Radix(TCD).Furthermore,7 association rules were obtained,namely Frankincense+Angelica Sinensis→Myrrha,Frankincense→Myrrha,Frankincense+Achyranthes Bidentatae Radix(TCD)→Myrrha,Myrrha+Eucommiae Cortex→Frankincense,Myrrha+Achyranthes Bidentatae Radix(TCD)→Frankincense,Achyranthes Bidentatae Radix(TCD)+Dipsaci Radix→Eucommiae Cortex and Carthamus tinctorius+Frankincense→Myrrha.The results of analysis on complex network-based prescription rules showed that Achyranthes Bidentatae Radix(TCD),Eucommiae Cortex and Angelica Sinensis were used as the core CHs.Conclusion:The CHs are often the ones presented with warm,neutral and cold properties and pungent,bitter and sweet flavors and mainly act on liver meridians,kidney meridians,spleen meridians and heart meridians in oral TCM compounds for treatment of LDH in national patent database.Angelica Sinensis,Achyranthes Bidentatae Radix(TCD),Eucommiae Cortex,Angelicae Pubescentis Radix(TCD),Myrrha and Frankincense are usually used as the core of the oral TCM compounds.

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备注/Memo

备注/Memo:
基金项目:基于中医临床研究基地优势病种及扩展病种疗效评价研究项目(国中医药科技中医便函﹝2021﹞36号) 通讯作者:邓强 E-mail:1031518835@qq.com
更新日期/Last Update: 1900-01-01