[1]张元斌,张玉良,罗程,等.经皮椎体成形术与非手术疗法治疗骨质疏松性椎体压缩骨折疗效比较的Meta分析[J].中医正骨,2023,35(07):34-39,45.
　ZHANG Yuanbin,ZHANG Yuliang,LUO Cheng,et al.Clinical outcomes of percutaneous vertebroplasty versus non-operative therapies for treatment of osteoporotic vertebral compression fracture:a meta-analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(07):34-39,45.
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经皮椎体成形术与非手术疗法治疗骨质疏松性椎体压缩骨折疗效比较的Meta分析()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年07期
页码:
34-39,45
栏目:
文献研究
出版日期:
2023-07-20

文章信息/Info

Title:
Clinical outcomes of percutaneous vertebroplasty versus non-operative therapies for treatment of osteoporotic vertebral compression fracture:a meta-analysis
作者:
张元斌1; 张玉良1; 罗程1; 赵瑛1; 施华萍1; 郎永2; 孙奇2
(1.杭州市富阳中医骨伤医院,浙江 杭州 311400; 2.张绍富中医骨伤学术研究所,浙江 杭州 311400)
Author(s):
ZHANG Yuanbin1; ZHANG Yuliang1; LUO Cheng1; ZHAO Ying1; SHI Huaping1; LANG Yong2; SUN Qi2
1.Hangzhou Fuyang Hospital of Orthopedics of Traditional Chinese Medicine,Hangzhou 311400,Zhejiang,China 2.Academic Research Institute of TCM Orthopedics of ZHANG Shaofu,Hangzhou 311400,Zhejiang,China
关键词:
骨质疏松性骨折;  脊柱骨折;  椎体成形术;  非手术疗法;  专题Meta分析
Keywords:
osteoporotic fractures;  spinal fractures;  vertebroplasty;  nonoperative therapy;  meta-analysis as topic
摘要:
目的:系统评价经皮椎体成形术(percutaneous vertebroplasty,PVP)和非手术疗法治疗骨质疏松性椎体压缩骨折(osteoporotic vertebral compression fracture,OVCF)的临床疗效。方法:应用计算机检索中国知网、万方数据库、维普网、PubMed、Embase、Cochrane Library、Medline中比较PVP和非手术疗法治疗OVCF临床疗效的随机对照试验,检索时限均为建库至2022年1月。同时通过人工检索纳入文献的
Abstract:
Objective:To systematically review the clinical outcomes of percutaneous vertebroplasty(PVP)versus non-operative therapies in treatment of osteoporotic vertebral compression fracture(OVCF).Methods:All the randomized controlled trial(RCT)articles about the clinical outcomes of PVP(operation group)versus non-operative therapies(non-operation group)in treatment of OVCF included from database establishing to January 2022 were retrieved from the China National Knowledge Internet,Wanfang Database,Vip Database,PubMed,Embase,Cochrane Library and Medline through computer,meanwhile,the references of the included articles were manually retrieved for supplementing.The patients in operation group were treated with PVP,while the ones in non-operation group with non-operative therapies such as fixing and braking,physicotherapeutics and oral application of analgesics.The articles were screened and the information was extracted independently by two researchers according to the inclusion and exclusion criteria.The methodological quality of research in the articles was evaluated respectively independently by the same two researchers,and if any disagreement was found between them,discussion was conducted or another researcher was invited for making a final decision,and then a Meta-analysis was conducted by using RevMan5.3 software.Results:Eight RCT articles(748 patients)were included in the final analysis,380 patients in operation group and 368 ones in non-operation group.The results of Meta-analysis revealed that the posttreatment low back pain visual analogue scale(VAS)score and the posttreatment quality of life questionnaire of the European Foundation for Osteoporosis(QUALEFFO)score were lower in operation group compared to non-operation group(MD=-1.62,95%CI(-1.91,-1.32),P=0.000; MD=-5.62,95%CI(-8.94,-2.30),P=0.001).The results of subgroup analysis showed that the low back pain VAS scores were all lower in operation group compared to non-operation group within 1 month after the treatment,at 1-3 months after the treatment and over 3 months after the treatment respectively(MD=-1.78,95%CI(-2.63,-0.93),P=0.000; MD=-1.71,95%CI(-2.11,-1.31),P=0.000; MD=-1.29,95%CI(-1.69,-0.88),P=0.000).The QUALEFFO score was lower in operation group compared to non-operation group within 1 month after the treatment(MD=-6.25,95%CI(-11.69,-0.81),P=0.000),while,at 1-3 months after the treatment and over 3 months after the treatment,there was no statistical difference between the 2 groups(MD=-6.49,95%CI(-15.32,2.33),P=0.150; MD=-3.48,95%CI(-9.64,2.68),P=0.270).Publication bias was analyzed based on the posttreatment pain VAS scores,and the results of Egger's test showed that there was no publication bias in the included articles(within 1 month after the treatment:P=0.452; at 1-3 months after the treatment:P=0.633; over 3 months after the treatment:P=0.532).Conclusion:PVP is better than non-operative therapies in clinical outcomes in treatment of OVCF.

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中医正骨2023年7月第35卷第7期 J Trad Chin Orthop Trauma,2023,Vol.35,No.7(总519)
(总520)中医正骨2023年7月第35卷第7期 J Trad Chin Orthop Trauma,2023,Vol.35,No.7
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备注/Memo

备注/Memo:
基金项目:浙江省医药卫生科技计划项目(2020KY806) 通讯作者:张玉良 E-mail:zyb2am@126.com
更新日期/Last Update: 1900-01-01