[1]任我行,丁立鹏,詹红生.中医体质类型与腰椎间盘突出症关系的Meta分析[J].中医正骨,2023,35(05):20-24.
　REN Woxing,DING Lipeng,ZHAN Hongsheng.The relationship between TCM constitution types and lumbar disc herniation:a meta-analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(05):20-24.
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中医体质类型与腰椎间盘突出症关系的Meta分析()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年05期
页码:
20-24
栏目:
文献研究
出版日期:
2023-05-20

文章信息/Info

Title:
The relationship between TCM constitution types and lumbar disc herniation:a meta-analysis
作者:
任我行; 丁立鹏; 詹红生
(上海中医药大学附属曙光医院,上海 201203)
Author(s):
REN Woxing; DING Lipeng; ZHAN Hongsheng
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
关键词:
椎间盘移位;  腰椎;  中医体质;  专题Meta分析
Keywords:
intervertebral disc displacement;  lumbar vertebrae;  body constitution(TCM);  meta-analysis as topic
摘要:
目的:探讨中医体质类型与腰椎间盘突出症(lumbar disc herniation,LDH)的关系。方法:运用计算机检索中国知网、万方数据库、维普网、中国生物医学文献服务系统、PubMed、Embase、Cochrane Library、Medline中有关中医体质类型与LDH关系的观察性研究文献,检索时限均为建库至2022年11月17日。经文献筛选、数据提取及偏倚风险评价后,采用Stata17.0软件分析LDH患者中不同中医体质类型所占比例及中医体质类型与LDH的关系,并用漏斗图进行发表偏倚分析。结果:共检索到136篇文献,经过逐层筛选最终纳入10篇文献,其中横断面研究7项、病例对照研究3项。Meta分析结果显示,LDH患者中血瘀质、湿热质、阳虚质所占比例较高[21.71%,95%CI(0.19,0.26),P=0.000; 17.12%,95%CI(0.15,0.19),P=0.000; 15.17%,95%CI(0.11,0.21),P=0.000],平和质、气郁质、气虚质、特禀质所占比例较低[9.60%,95%CI(0.04,0.16),P=0.004; 6.47%,95%CI(0.04,0.08),P=0.000; 5.92%,95%CI(0.05,0.07),P=0.000; 1.53%,95%CI(0.01,0.03),P=0.000]; 血瘀质和阳虚质是LDH的危险因素[OR=1.01,95%CI(0.66,1.37),P=0.000; OR=0.89,95%CI(0.53,1.25),P=0.000],平和质是LDH的保护因素[OR=-2.02,95%CI(-2.43,-1.62),P=0.000],其他中医体质类型与LDH的发生无明显关系。以针对LDH患者中血瘀质所占比例的7项横断面研究进行发表偏倚分析,漏斗图两侧不完全对称,提示可能存在发表偏倚。结论:现有的证据表明,中医体质类型与LDH的发病有关,血瘀质、阳虚质是LDH的危险因素,平和质是LDH的保护因素。
Abstract:
Objective:To explore the relationship between TCM constitution types and lumbar disc herniation(LDH).Methods:All observational research articles about the relationship between TCM constitution types and LDH included from database establishing to November 17,2022 were retrieved from China National Knowledge Internet,Wanfang Database,Vip Database,Chinese Biomedical Literature Service System,PubMed,Embase,Cochrane Library and Medline through computer.The articles were screened,the information was extracted and the bias risk of the research in the articles was evaluated independently by two researchers according to the inclusion and exclusion criteria,and if any disagreement was found between them,another researcher was invited for making a final decision,and then a Meta-analysis on the proportion of different TCM constitution types in LDH patients and the relationship between TCM constitution types and LDH was conducted by using Stata17.0 software,furthermore,the publication bias was analyzed by using funnel plot.Results:One hundred and thirty-six articles were searched out.After screening,10 articles were included in the final analysis,including 7 cross-sectional study articles and 3 case-control study articles.The results of Meta-analysis revealed that the Stagnant-blood constitution,Damp-heat constitution and Yang-deficient constitution accounted for a high proportion(21.71%,95%CI(0.19,0.26),P=0.000; 17.12%,95%CI(0.15,0.19),P=0.000; 15.17%,95%CI(0.11,0.21),P=0.000),while the Balanced constitution(TCM),Stagnant-qi constitution(TCM),Qi-deficient constitution and Inherited-special constitution accounted for a low proportion in LDH patients(9.60%,95%CI(0.04,0.16),P=0.004; 6.47%,95%CI(0.04,0.08),P=0.000; 5.92%,95%CI(0.05,0.07),P=0.000; 1.53%,95%CI(0.01,0.03),P=0.000).The Stagnant-blood constitution and Yang-deficient constitution were the risk factors for LDH(OR=1.01,95%CI(0.66,1.37),P=0.000; OR=0.89,95%CI(0.53,1.25),P=0.000),while the Balanced constitution(TCM)was the protective factor for LDH(OR=-2.02,95%CI(-2.43,-1.62),P=0.000).No obvious relationship was found between the other TCM constitution types and the occurrence of LDH.Publication bias was analyzed according to Funnel plot drawned based on the proportion of Stagnant-blood constitution in LDH patients in the 7 cross-sectional studies,and the asymmetrical funnel plots demonstrated that there might be publication bias.Conclusion:Available evidences suggest that the occurrence of LDH is related to TCM constitution types.The Stagnant-blood constitution and Yang-deficient constitution are the risk factors,while the Balanced constitution(TCM)is the protective factor for LDH.

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备注/Memo

备注/Memo:
基金项目:上海市2020年度“科技创新行动计划”医学创新研究专项(20MC1920600); 上海市临床重点专科(中医骨伤科)建设项目(shslczdzk03901) 通讯作者:詹红生 E-mail:13918449223@139.com
更新日期/Last Update: 1900-01-01