[1]李琰,孙鹏,孙晋客,等.消肿止痛胶囊在Danis-Weber C型踝关节骨折术前治疗中的应用[J].中医正骨,2022,34(05):17-20.
　LI Yan,SUN Peng,SUN Jinke,et al.Oral application of Xiaozhong Zhitong(消肿止痛)capsule to preoperative treatment of Danis-Weber type C ankle fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2022,34(05):17-20.
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消肿止痛胶囊在Danis-Weber C型踝关节骨折术前治疗中的应用()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期数:
2022年05期
页码:
17-20
栏目:
临床研究
出版日期:
2022-05-20

文章信息/Info

Title:
Oral application of Xiaozhong Zhitong(消肿止痛)capsule to preoperative treatment of Danis-Weber type C ankle fractures
作者:
李琰; 孙鹏; 孙晋客; 姜红江; 乔永平
(山东省文登整骨医院,山东 威海 264400)
Author(s):
LI Yan; SUN Peng; SUN Jinke; JIANG Hongjiang; QIAO Yongping
Shandong Wendeng Osteopathic Hospital,Weihai 264400,Shandong,China
关键词:
踝关节;  骨折; 闭合性;  消肿止痛胶囊;  肿胀;  水疱;  临床试验
Keywords:
ankle joint;  fractures; closed;  Xiaozhong Zhitong capsule;  swelling;  blister;  clinical trial
摘要:
目的:观察消肿止痛胶囊在Danis-Weber C型踝关节骨折术前治疗中的应用价值。方法:将符合要求的50例Danis-Weber C型踝关节骨折患者随机分为2组,每组25例。常规治疗组给予局部冷敷、抬高患肢、加压包扎、静脉滴注复方甘露醇注射液及患肢功能锻炼等治疗,消肿止痛胶囊组在常规治疗组的基础上给予口服消肿止痛胶囊治疗,均治疗至踝关节肿胀消退、皮肤出现皱褶。分别于治疗前及治疗开始后24 h、72 h、120 h比较2组患者的术前踝关节肿胀值,于治疗结束时分别比较2组患者术前等待时间及术前张力性水疱发生率,并观察并发症发生情况。结果:①受试者退出情况。消肿止痛胶囊组1例患者因中途撤回知情同意书而脱落; 常规治疗组1例患者因未按医嘱要求配合治疗而剔除,1例患者因治疗期间月经来潮而脱落。②术前踝关节肿胀值。时间因素和分组因素存在交互效应(F=4.057,P=0.020)。2组患者术前踝关节肿胀值总体比较,差异有统计学意义,即存在分组效应(F=24.861,P=0.000)。治疗前后不同时间点之间术前踝关节肿胀值的差异有统计学意义,即存在时间效应(F=361.960,P=0.000); 2组患者术前踝关节肿胀值随时间延长均呈先升高后下降的趋势[(3.46±0.23)cm,(4.18±0.79)cm,(5.49±0.39)cm,(2.16±0.32)cm,F=425.641,P=0.000;(3.37±0.38)cm,(4.56±0.85)cm,(5.97±0.33)cm,(2.76±0.23)cm,F=434.131,P=0.000]; 治疗前及治疗开始后24 h,2组患者的术前踝关节肿胀值比较,差异无统计学意义(t=0.871,P=0.390; t=-1.590,P=0.120); 治疗开始后72 h、120 h,消肿止痛胶囊组的术前踝关节肿胀值均低于常规治疗组(t=-4.220,P=0.000; t=-7.400,P=0.000)。③术前张力性水疱发生率。治疗结束时,常规治疗组7例出现张力性水疱,消肿止痛胶囊组1例出现张力性水疱; 消肿止痛胶囊组张力性水疱发生率低于常规治疗组(χ2=4.029,P=0.045)。④术前等待时间。消肿止痛胶囊组术前等待时间(5,1)d,常规治疗组术前等待时间(6,2)d; 消肿止痛胶囊组术前等待时间短于常规治疗组(Z=-4.384,P=0.000)。⑤安全性。治疗期间47例患者均未出现并发症。结论:对于Danis-Weber C型踝关节骨折患者,术前在常规治疗的基础上,采用口服消肿止痛胶囊治疗,能有效消除踝关节肿胀,降低张力性水疱发生率,缩短术前等待时间,且安全性高。
Abstract:
Objective:To observe the applied values of oral application of Xiaozhong Zhitong(消肿止痛,XZZT)capsule in preoperative treatment of Danis-Weber type C ankle fractures.Methods:Fifty patients who would receive surgery for Danis-Weber type C ankle fractures were selected and randomly divided into conventional treatment group and XZZT capsule group,25 cases in each group.All patients in the 2 groups were treated with the conventional therapies including local cold compression,raising the injured limbs,compression bandaging,intravenous drip infusion of compound mannitol injection and ankle function exercises before the surgery.Moreover,the patients in XZZT capsule group were further treated with oral application of XZZT capsules.All patients in the 2 groups were treated till the swelling was subsided and skin folds appeared in ankle.The preoperative ankle swelling value was compared between the 2 groups before the treatment and at 24,72 and 120 hours after the beginning of the treatment respectively.Furthermore,the preoperative waiting time and preoperative tension blister incidence rate were compared between the 2 groups at the end of treatment,and the complications were observed.Results:①One patient in XZZT capsule group and 1 case in conventional treatment group dropped out of the study for withdrawal of informed consent form and menstruation during the treatment respectively.Moreover,1 patient in conventional treatment group was excluded for failing to coordinate the treatment as required.②There was interaction between time factor and group factor in preoperative ankle swelling value(F=4.057,P=0.020).There was statistical difference in preoperative ankle swelling value between the 2 groups in general,in other words,there was group effect(F=24.861,P=0.000).There was statistical difference in preoperative ankle swelling value between different timepoints before and after the treatment,in other words,there was time effect(F=361.960,P=0.000).The preoperative ankle swelling value presented a time-dependent trend of increasing firstly and decreasing subsequently in the 2 groups(3.46±0.23,4.18±0.79,5.49±0.39,2.16±0.32 cm,F=425.641,P=0.000;3.37±0.38,4.56±0.85,5.97±0.33,2.76±0.23 cm,F=434.131,P=0.000).There was no statistical difference in preoperative ankle swelling value between the 2 groups before the treatment and at 24 hours after the beginning of the treatment(t=0.871,P=0.390; t=-1.590,P=0.120),while the preoperative ankle swelling value was smaller in XZZT capsule group compared to conventional treatment group at 72 and 120 hours after the beginning of the treatment(t=-4.220,P=0.000; t=-7.400,P=0.000).③At the end of treatment,the tension blisters were found in 7 patients in conventional treatment group and 1 patient in XZZT capsule group.The incidence rate of tension blister was lower in XZZT capsule group compared to conventional treatment group(χ2=4.029,P=0.045).④The preoperative waiting time was(5,1)days in XZZT capsule group and(6,2)days in conventional treatment group.The preoperative waiting time was shorter in XZZT capsule group compared to conventional treatment group(Z=-4.384,P=0.000).⑤No complications were found in the 2 groups during the treatment period.Conclusion:Combination of conventional therapies with oral application of XZZT capsules can effectively eliminate ankle swelling,reduce the incidence rate of tension blisters and shorten the preoperative waiting time in patients who will receive surgery for Danis-Weber type C ankle fractures,and it has high safety.

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备注/Memo

备注/Memo:
基金项目:山东省中医药科技项目(2020M213); 威海市第三批中医重点专科建设项目(威卫计中医〔2017〕14号) 通讯作者:孙晋客 E-mail:sunjinke315@163.com
更新日期/Last Update: 1900-01-01