[1]许一帆,樊炳楷,黄金山,等.肌少-骨质疏松症的研究进展膏方及其在骨科疾病治疗中的应用[J].中医正骨,2019,31(05):22-25.
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肌少-骨质疏松症的研究进展膏方及其在骨科疾病治疗中的应用()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年05期
页码:
22-25
栏目:
综 述
出版日期:
2019-05-20

文章信息/Info

作者:
许一帆; 樊炳楷; 黄金山; 王艺超; 刘晋闽
(浙江中医药大学第一临床医学院,浙江 杭州 310006)
关键词:
骨质疏松;  肌肉减少症;  肌少-骨质疏松症;  综述
摘要:
肌少-骨质疏松症,是在骨质疏松症的基础上合并骨骼肌量减少及活动能力减弱的一类疾病。该病肌量减少和骨质疏松同时存在,二者互相影响,可致患者步速减慢、平衡能力减弱,易发生跌倒而致骨折,严重影响患者的生活质量。随着人口老龄化的加剧,肌少-骨质疏松症的发病率必将呈上升趋势。为提高对该病的认识,本文从发病机制、诊断标准及预防与治疗3个方面对肌少-骨质疏松症的研究进展进行了综述。

参考文献/References:

[1] DAWSON A,DENNISON E.Measuring the musculoskeletal aging phenotype[J].Maturitas,2016,93:13-17. [2] 马远征,王以朋,刘强,等.中国老年骨质疏松症诊疗指南(2018)[J].中国骨质疏松杂志,2018,24(12):1541-1567. [3] FIELDING R A,VELLAS B,EVANS W J,et al.Sarcopenia:an undiagnosed condition in older adults.Current consensus definition:prevalence,etiology,and consequences.International working group on sarcopenia[J].J Am Med Dir Assoc,2011,12(4):249-256. [4] SZULC P,FEYT C,CHAPURLAT R.High risk of fall,poor physical function,and low grip strength in men with fracture—the STRAMBO study[J].J Cachexia Sarcopenia Muscle,2016,7(3):299-311. [5] CHENG Q,ZHU X,ZHANG X,et al.A cross-sectional study of loss of muscle mass corresponding to sarcopenia in healthy Chinese men and women:reference values,prevalence,and association with bone mass[J].J Bone Miner Metab,2014,32(1):78-88. [6] GO S W,CHA Y H,LEE J A,et al.Association between sarcopenia,bone density,and health-related quality of life in Korean men[J].Korean J Fam Med,2013,34(4):281-288. [7] YOSHIMURA N,MURAKI S,OKA H,et al.Is osteoporosis a predictor for future sarcopenia or vice versa?Four-year observations between the second and third ROAD study surveys[J].Osteoporos Int,2017,28(1):189-199. [8] PEREIRA F B,LEITE A F,DE PAULA A P.Relationship between pre-sarcopenia,sarcopenia and bone mineral density in elderly men[J].Arch Endocrinol Metab,2015,59(1):59-65. [9] BINKLEY N,BUEHRING B.Beyond FRAX:it's time to consider “sarco-osteopenia”[J].J Clin Densitom,2009,12(4):413-416. [10] BINKLEY N,KRUEGER D,BUEHRING B.What's in a name revisited:should osteoporosis and sarcopenia be considered components of “dysmobility syndrome?”[J].Osteoporos Int,2013,24(12):2955-2959. [11] GIRGIS C M.Integrated therapies for osteoporosis and sarcopenia:from signaling pathways to clinical trials[J].Calcif Tissue Int,2015,96(3):243-255. [12] BONEWALD L F,KIEL D,CLEMENS T,et al.Forum on bone and skeletal muscle interactions:summary of the proceedings of an ASBMR workshop[J].J Bone Mine Res,2013,28(9):1857-1865. [13] FROST H M.Bone's mechanostat:A 2003 update[J].Anat Rec A Discov Mol Cell Evol Biol,2003,275A(2):1081-1101. [14] QIN W P,SUN L,CAO J,et al.The central nervous system(CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures[J].J Biol Chem,2013,288(19):13511-13521. [15] COLAIANNI G,CUSCITO C,MONGELLI T A,et al.The myokine irisin increases cortical bone mass[J].Proc Natl Acad Sci U S A,2015,112(39):12157-12162. [16] 马剑雄,匡明杰,何伟伟,等.肌肉减少症与骨质疏松的相关性:研究与应用[J].中国组织工程研究,2018,22(32):5222-5227. [17] KARSENTY G,OLSON E N.Bone and muscle endocrine functions:unexpected paradigms of inter-organ communication[J].Cell,2016,164(6):1248-1256. [18] WANNENES F,PAPA V,GRECO E A,et al.Abdominal fat and sarcopenia in women significantly alter osteoblasts homeostasis in vitro by a WNT/β-catenin dependent mechanism[J].Int J Endocrinol,2014:278316 [19] YANG S Y,HOY M,FULLER B,et al.Pretreatment with insulin-like growth factor I protects skeletal muscle cells against oxidative damage via PI3K/Akt and ERK1/2 MAPK pathways[J].Lab Invest,2010,90(3):391-401. [20] URANO T,INOUE S.Recent genetic discoveries in osteoporosis,sarcopenia and obesity[J].Endocr J,2015,62(6):475-484. [21] 薛瑜,王鸥,邢小平.肌少症筛查工具[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(5):483-490. [22] CRUZ-JENTOFT A J,BAHAT G,BAUER J,et al.Sarcopenia:revised European consensus on definition and diagnosis[J].Age Ageing,2019,48(1):16-31. [23] CHEN L K,LIU L K,WOO J,et al.Sarcopenia in Asia:consensus report of the Asian working group for sarcopenia[J].J Am Med Dir Assoc,2014,15(2):95-101. [24] 张智海,刘忠厚,李娜,等.中国人骨质疏松症诊断标准专家共识(第三稿·2014版)[J].中国骨质疏松杂志,2014,20(9):1007-1010. [25] MA X H,ZHANG W,WANG Y,et al.Comparison of the spine and hip bmd assessments derived from quantitative computed tomography[J].Int J Endocrinol,2015:675340. [26] CRUZ-JENTOFT A J,LANDI F,SCHNEIDER S M,et al.Prevalence of and interventions for sarcopenia in ageing adults:a systematic review.Report of the International Sarcopenia Initiative(EWGSOP and IWGS)[J].Age Ageing,2014,43(6):748-759. [27] PAHOR M,GURALNIK J M,AMBROSIUS W T,et al.Effect of structured physical activity on prevention of major mobility disability in older adults the life study randomized clinical trial[J].JAMA,2014,311(23):2387-2396. [28] MORLEY J E,ARGILES J M,EVANS W J,et al.Nutritional recommendations for the management of sarcopenia[J].J Am Med Dir Assoc,2010,11(6):391-396. [29] BEAUDART C,BUCKINX F,RABENDA V,et al.The effects of vitamin D on skeletal muscle strength,muscle mass,and muscle power:a systematic review and meta-analysis of randomized controlled trials[J].J Clin Endocrinol Metab,2014,99(11):4336-4345. [30] MUIR S W,MONTERO-ODASSO M.Effect of vitamin D supplementation on muscle strength,gait and balance in older adults:a systematic review and Meta-Analysis[J].J Am Geriatr Soc,2011,59(12):2291-2300. [31] MORLEY J E.Pharmacologic options for the treatment of sarcopenia[J].Calcif Tissue Int,2016,98(4):319-333. [32] KOVACHEVA E L,HIKIM A P,SHEN R,et al.Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin,c-Jun NH2-terminal kinase,Notch,and Akt signaling pathways[J].Endocrinology,2010,151(2):628-638. [33] PAPANICOLAOU D A,ATHER S N,ZHU H,et al.A phase IIA randomized,placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator(SARM),MK-0773 in female participants with sarcopenia[J].J Nutr Health Aging,2013,17(6):533-543. [34] WHITE H K,PETRIE C D,LANDSCHULZ W,et al.Effects of an oral growth hormone secretagogue in older adults[J].J Clin Endocrinol Metab,2009,94(4):1198-1206.

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更新日期/Last Update: 2019-05-20