[1]李春雯.益气温经法对绝经后骨质疏松性髋部骨折患者 骨转换指标的影响[J].中医正骨,2014,26(12):7-9.
　Li Chunwen*.Effect of the therapeutic methods(TCM)of Reinforcing QI Warming Meridians on bone turnover indicators in patients with postmenopausal osteoporotic hip fracture[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(12):7-9.
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益气温经法对绝经后骨质疏松性髋部骨折患者 骨转换指标的影响()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期数:
2014年12期
页码:
7-9
栏目:
临床研究
出版日期:
2014-12-30

文章信息/Info

Title:
Effect of the therapeutic methods(TCM)of Reinforcing QI Warming Meridians on bone turnover indicators in patients with postmenopausal osteoporotic hip fracture
作者:
李春雯
浙江中医药大学,浙江 杭州 310053
Author(s):
Li Chunwen*
Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China
关键词:
骨质疏松; 绝经后 骨质疏松性骨折 髋骨折 益气 温经 强骨饮 骨密度 骨生成 骨吸收
Keywords:
Osteoporosis; postmenopausal;  Osteoporotic fractures;  Hip fractures;  Reinforcing QI;  Warming meridians;  Qianggu Yin;  Bone mineral density;  Osteogenesis;  Bone resorption
摘要:
目的:观察益气温经法对绝经后骨质疏松性髋部骨折患者骨形成和骨吸收指标的影响。方法:将符合要求的75例绝经后骨 质疏松性单侧髋部骨折患者随机分为2组,中药组37例、对照组38例。髋部骨折手术后,对照组口服钙尔奇D片和阿法骨化醇胶囊, 每天1次,服用6个月,同时指导患者进行规范的功能锻炼; 中药组在对照组用药及功能锻炼的基础上口服强骨饮进行治疗,强骨饮 每天2次,服用6个月。分别于治疗前和治疗6个月后测定2组患者的骨密度、Ⅰ型胶原N前端肽和Ⅰ型胶原C末端肽血清含量。结果 :治疗前2组患者腰椎骨密度比较,差异无统计学意义[(0.757±0.067)g·cm-2,(0.753±0.065) g·cm-2,t=0.297,P=0.767]; 治疗6个月后,2组患者的腰椎骨密度均增大,中药组骨密度的增加值大于对照组 [(0.018±0.025)g·cm-2,(0.005±0.027)g·cm-2,t=2.078,P=0.041]。治疗前2组患者的Ⅰ 型胶原N前端肽和Ⅰ型胶原C末端肽血清含量比较,组间差异均无统计学意义[(46.27±9.35)ng·mL-1, (43.73±9.39)ng·mL-1,t=1.175,P=0.244;(0.577±0.236)ng·mL-1,(0.550±0.206)ng ·mL-1,t=0.530,P=0.598]; 治疗6个月后中药组患者的Ⅰ型胶原N前端肽和Ⅰ型胶原C末端肽血清含量均小于对照组 [(35.16±6.76)ng·mL-1,(46.61±9.04)ng·mL-1,t=6.198,P=0.000;(0.304±0.078)ng ·mL-1,(0.422±0.180)ng·mL-1,t=3.744,P=0.000]。结论:益气温经法可通过降低Ⅰ型胶原N前 端肽和Ⅰ型胶原C末端肽的血清含量,抑制骨骼的高转换状态,提高骨量,达到防治绝经后骨质疏松性髋部骨折的目的。
Abstract:
Objective:To observe the effect of the therapeutic methods(TCM)of Reinforcing QI Warming Meridians on bone turnover indicators in patients with postmenopausal osteoporotic hip fracture.Methods:Seventy-five patients with unilateral postmenopausal osteoporotic hip fracture enrolled in the study were randomly divided into traditional chinese medicine(TCM)group(37 cases)and control group(38 cases).The patients in control group were treated with oral application of Caltrate D tablets and Alfacalcidol capsules,once a day for consecutive 6 months.Meanwhile,normative functional exercises were performed with guidance from nurses.The patients in TCM group were treated with not only the same treatment but also oral application of Qianggu Yin(强骨饮)twice a day for consecutive 6 months.Bone mineral density(BMD)and serum concentrations of procollagenⅠN-terminal propeptide(PⅠNP)and collagen typeⅠC-terminal cross-linked telopeptide(CTX)were measured and compared between the 2 groups before treatment and after 6-month treatment respectively.Results:There was no statistical difference in lumbar vertebrae BMD between the 2 groups before the treatment(0.757+/-0.067 vs 0.753+/-0.065 g/cm(2),t=0.297,P=0.767),while the lumbar vertebrae BMD increased in both of the 2 groups after 6-month treatment and the increase value was greater in TCM group(0.018+/-0.025 vs 0.005+/-0.027 g/cm (2),t=2.078,P=0.041).There was no statistical difference in the serum concentrations of PⅠNP and CTX between the 2 groups before the treatment(46.27+/-9.35 vs 43.73+/-9.39 ng/ml,t=1.175,P=0.244; 0.577+/-0.236 vs 0.550+/-0.206 ng/ml,t=0.530,P=0.598),while the serum concentrations of PⅠNP and CTX were lower in the TCM group compared with the control group after 6-month treatment(35.16+/-6.76 vs 46.61+/-9.04 ng/ml,t=6.198,P=0.000; 0.304+/-0.078 vs 0.422+/-0.180 ng/ml,t=3.744,P=0.000).Conclusion:The therapeutic methods(TCM)of Reinforcing QI Warming Meridians can inhibit the high bone transition and increase bone mass by means of reducing the serum concentrations of PⅠNP and CTX,so it can prevent the postmenopausal osteoporotic hip fractures.

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备注/Memo

备注/Memo:
基金项目:2013年国家中医药行业科研专项项目(201307010); 2012年浙江省中医药重点项目(2012ZZ007)
通讯作者:李春雯 E-mail:chunwen2007@163.com
更新日期/Last Update: 2014-12-30