[1]杨爱娟,徐保平,王晓涛.新风胶囊治疗强直性脊柱炎临床疗效的系统评价[J].中医正骨,2020,32(07):12-16.
　YANG Aijuan,XU Baoping,WANG Xiaotao.Clinical efficacy of Xinfeng(新风)capsule for treatment of ankylosing spondylitis:a systematic review[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2020,32(07):12-16.
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新风胶囊治疗强直性脊柱炎临床疗效的系统评价()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第32卷
期数:
2020年07期
页码:
12-16
栏目:
文献研究
出版日期:
2020-07-20

文章信息/Info

Title:
Clinical efficacy of Xinfeng(新风)capsule for treatment of ankylosing spondylitis:a systematic review
作者:
杨爱娟1; 徐保平2; 王晓涛3
1.北京中医药大学,北京 100029; 2.六安市中医院,安徽 六安 237000; 3.无锡市锡山人民医院鹅湖分院,江苏 无锡 214116
Author(s):
YANG Aijuan1; XU Baoping2; WANG Xiaotao3
1.Beijing University of Chinese Medicine,Beijing 100029,China 2.Traditional Chinese Hospital of Lu'an,Lu'an 237000,Anhui,China 3.Ehu branch of Xishan People's Hospital of Wuxi City,Wuxi 214116,Jiangsu,China
关键词:
脊柱炎; 强直性;  Meta分析;  柳氮磺胺吡啶;  新风胶囊
Keywords:
spondylitis; ankylosing;  Meta-analysis;  sulfasalazine;  Xinfeng capsule
摘要:
目的:系统评价新风胶囊治疗强直性脊柱炎的临床疗效。方法:检索Cochrane Library、CBM、CNKI、Pubmed、Web of Science、VIP、WanFang Data建库至2019年8月收录的新风胶囊治疗强直性脊柱炎的临床研究文献。中文检索词为“新风胶囊”“强直性脊柱炎”; 英文检索词为“Xinfeng capsule”“ankylosing spondylitis”。由2名研究者独立筛选文献、提取文献中的数据资料。对纳入文献进行质量评价后进行Meta分析。结果:共检索到101篇文献,经筛选后最终纳入10篇文献。纳入的10篇文献,9篇文献说明了随机方法,1篇仅提及“随机”未说明具体方法; 均未提及分配隐藏和盲法; 结局数据均未缺失; 6篇文献无选择性报告,其余4篇研究信息不全、难以判断; 均无法判断其他偏倚来源。Meta分析结果显示,新风胶囊治疗强直性脊柱炎,治疗后患者的Bath强直性脊柱炎活动性指数、Bath强直性脊柱炎功能指数、Bath强直性脊柱炎整体指数、疼痛视觉模拟量表评分均低于柳氮磺胺吡啶治疗[I2=80%,MD=-0.86,95%CI(-1.21,-0.51); I2=45%,MD=-0.74,95%CI(-0.90,-0.59); I2=47%,MD=-0.88,95%CI(-1.04,-0.72); I2=82%,MD=-1.27,95%CI(-1.66,-0.88)]。结论:新风胶囊治疗强直性脊柱炎可有效缓解症状、提高患者生活质量。
Abstract:
Objective:To systematically review the clinical efficacy of Xinfeng(新风,XF)capsule for treatment of ankylosing spondylitis(AS).Methods:All clinical trial articles about XF capsule for treatment of AS included from database establishing to August 2019 were retrieved from Cochrane Library,CBM,China national knowledge internet,Pubmed,Web of Science,VIP Database and WanFang Data through computer.The logical combination of“新风胶囊”and“强直性脊柱炎”were used as Chinese index terms,and the logical combination of Xinfeng capsule and ankylosing spondylitis as the English index terms.The articles were screened and the information was extracted independently by two searchers.The methodological quality of research in the articles was evaluated and a Meta-analysis was conducted.Results:One hundred and one articles were searched out.After screening,10 articles were included in the final analysis,including 9 articles in which randomization method was described and 1 article in which only randomization was mentioned and randomization method was not described.Meanwhile,the reports were non-selective in 6 articles and were difficult to judge for incomplete information in the other four articles.Besides,the allocation concealment and blind method were not mentioned,and outcome data were complete in all of the 10 articles,and other sources of bias couldn't be identified.The results of Meta-analysis demonstrated that the posttreatment Bath ankylosing spondylitis disease active index(BASDAI),Bath ankylosing spondylitis functional index(BASFI),Bath ankylosing spondylitis global index(BAS-G)and pain visual analog scale(VAS)scores were lower in patients who received XF capsule compared to patients who received sulfasalazine for treatment of AS(I2=80%,MD=-0.86,95%CI(-1.21,-0.51); I2=45%,MD=-0.74,95%CI(-0.90,-0.59); I2=47%,MD=-0.88,95%CI(-1.04,-0.72); I2=82%,MD=-1.27,95%CI(-1.66,-0.88)).Conclusion:XF capsule can effectively relieve symptoms and improve patient's life quality in treatment of AS.

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备注/Memo

备注/Memo:
通讯作者:王晓涛 E-mail:568832807@qq.com
更新日期/Last Update: 2020-07-20