[1]任伟凡,胡劲涛,全仁夫,等.强直性脊柱炎易感基因的相关研究进展[J].中医正骨,2019,31(04):48-51.
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强直性脊柱炎易感基因的相关研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年04期
页码:
48-51
栏目:
综 述
出版日期:
2019-04-30

文章信息/Info

作者:
任伟凡1; 胡劲涛1; 全仁夫2; 吕建兰1; 钱建胜1
(1.浙江中医药大学第三临床医学院,浙江 杭州 310053; 2.杭州市萧山区中医院,浙江 杭州 311201)
关键词:
脊柱炎; 强直性;  易感基因;  遗传;  多态性; 单核苷酸;  综述
摘要:
强直性脊柱炎(ankylosing spondylitis,AS)是临床上常见的一种具有高度遗传性的慢性炎症性疾病。HLA-B27基因被认为是与AS相关性最强的易感基因,但越来越多的研究发现,除HLA-B27基因外,包括内质网氨基肽酶1基因、白细胞介素23/白细胞介素17炎症轴相关基因、肿瘤坏死因子α基因、白细胞介素1基因、杀伤细胞免疫球蛋白样受体基因在内的多种基因均与AS的易感性有关。目前所发现的易感基因与AS关联的机制尚不十分清楚,仍须开展更多高质量、多角度、深层次的研究。

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者:全仁夫 E-mail:quanrenfu@126.com(收稿日期:2019-01-03 本文编辑:李晓乐)
更新日期/Last Update: 2019-10-08