[1]赫军,诸葛天谕,李冬冬,等.四联疗法治疗强直性脊柱炎[J].中医正骨,2016,28(06):50-52.
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四联疗法治疗强直性脊柱炎()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期数:
2016年06期
页码:
50-52
栏目:
临床报道
出版日期:
2016-06-20

文章信息/Info

作者:
赫军; 诸葛天谕; 李冬冬; 何宾; 郑永昌; 禹建春; 汤志刚; 孙捷
浙江省台州市博爱医院,浙江 台州 318050
关键词:
脊柱炎; 强直性;  中药疗法;  薰洗;  埋针;  功能锻炼
摘要:
目的:观察中药内服、中药薰蒸、痛点埋针和功能锻炼四联疗法治疗强直性脊柱炎的临床疗效和安全性。方法:2014年1月至2016年1月,采用中药内服、中药薰蒸、痛点埋针和功能锻炼四联疗法治疗强直性脊柱炎患者36例,男31例、女5例。年龄14～51岁,中位数23岁。病程3个月至16年,中位数3年。共治疗90 d。观察并对比治疗前后患者的中医证候积分、晨僵时间、疾病活动度评分、脊柱与胸廓活动度、枕墙距、臀地距、Bath功能指数评分、血清C-反应蛋白含量、血沉及并发症发生情况,并评价综合疗效。结果:治疗90 d后,中医证候积分低于治疗前[(21.06±6.84)分,(42.05±6.72)分,t=4.302,P=0.000],晨僵时间短于治疗前[(2.04±0.92)h,(5.31±3.04)h,t=4.101,P=0.001],疾病活动度评分低于治疗前[(5.31±0.74)分,(8.81±1.03)分,t=3.201,P=0.001],脊柱活动度与胸廓活动度大于治疗前[(5.06 ±1.04)cm,(2.95 ±1.02)cm,t=3.531,P=0.001;(2.14±1.02)cm,(1.03±0.86)cm,t=5.002,P=0.001],枕墙距和臀地距小于治疗前[(2.31±1.01)cm,(4.01±1.02)cm,t=4.328,P=0.000;(3.31±2.04)cm,(7.01 ±5.04)cm,t=4.579,P=0.000],Bath功能指数评分小于治疗前[(3.06±1.04)分,(7.85±1.02)分,t=3.022,P=0.001],血清C-反应蛋白和血沉低于治疗前[(3.24±1.02)mg·dL-1,(7.31±5.04)mg·dL-1,t=6.554,P=0.001;(38.22±5.36)mm·h-1,(88.36±6.27)mm·h-1,t=7.440,P=0.000]。便溏2例,食欲下降2例,恶心、干呕2例; 经对症处理后,上述不良反应均消失。治疗90 d后,参照《中药新药临床研究指导原则》中强直性脊柱炎的疗效评价标准评价疗效,临床缓解6例、显效15例、有效13例、无效2例。结论:采用中药内服、中药薰蒸、痛点埋针和功能锻炼四联疗法治疗强直性脊柱炎,能改善患者临床症状和体征,缩短晨僵时间,提高脊柱和胸廓活动度,有利于肢体功能的恢复,减轻关节炎症和畸形,减缓病情活动度,并发症少,值得临床推广应用。

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备注/Memo

备注/Memo:
基金项目:台州市科技计划项目(1401KY35)
更新日期/Last Update: 2016-06-30