[1]陈群群,崔俊英,霍少川,等.3种中医证型股骨头坏死患者的脂代谢特征对比研究[J].中医正骨,2019,31(01):1-4.
　CHEN Qunqun,CUI Junying,HUO Shaochuan,et al.Lipid metabolism characteristics of patients with three types of TCM syndrome of femur head necrosis:a comparative study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(01):1-4.
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3种中医证型股骨头坏死患者的脂代谢特征对比研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年01期
页码:
1-4
栏目:
临床研究
出版日期:
2019-01-20

文章信息/Info

Title:
Lipid metabolism characteristics of patients with three types of TCM syndrome of femur head necrosis:a comparative study
作者:
陈群群1; 崔俊英2; 霍少川3; 何敏聪3
(1.广州中医药大学第三附属医院,广东 广州 510378; 2.广州市越秀区妇幼保健院,广东 广州 510030; 3.广州中医药大学,广东 广州 510405)
Author(s):
CHEN Qunqun1; CUI Junying2; HUO Shaochuan3; HE Mincong3
1.The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510378,Guangdong,China 2.Maternal and Child Health Hospital of Yuexiu District,Guangzhou 510030,Guangdong,China 3.Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,China
关键词:
股骨头坏死;  证候;  血脂异常;  临床试验
Keywords:
femur head necrosis;  symptom complex;  dyslipidemias;  clinical trial
摘要:
目的:比较3种中医证型股骨头坏死患者的脂代谢特征。方法:对符合要求的97例股骨头坏死患者进行中医辨证分型,抽取外周静脉血,测定并对比不同中医证型股骨头坏死患者的血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、载脂蛋白(apolipoprotein,Apo)-A1、Apo -B含量。结果:纳入研究的97例患者中,痰瘀蕴结证32例、肾虚血瘀证45例、气滞血瘀证20例。3种证候类型患者的血清HDL-C、Apo-A1、Apo-B含量比较,差异均无统计学意义[HDL-C:(0.99±0.42)mmol·L-1,(1.14±0.34)mmol·L-1,(0.88±0.41)mmol·L-1,F=0.182,P=0.834; Apo-A1:(1.18±0.27)g·L-1,(1.15±0.22)g·L-1,(1.08±0.23)g·L-1,F=0.919,P=0.402; Apo-B:(0.84±0.22)g·L-1,(0.82±0.21)g·L-1,(0.72±0.20)g·L-1,F=0.167,P=0.846]。3种证候类型患者的血清TC、TG、LDL-C含量比较,差异均有统计学意义[TC:(4.77±0.97)mmol·L-1,(4.34±0.81)mmol·L-1,(4.00±1.25)mmol·L-1,F=6.211,P=0.003; TG:(2.13±1.49)mmol·L-1,(1.54±0.98)mmol·L-1,(1.83±1.27)mmol·L-1,F=3.107,P=0.049; LDL-C:(2.95±1.01)mmol·L-1,(2.86±0.77)mmol·L-1,(2.39±1.14)mmol·L-1,F=3.589,P=0.031]; 痰瘀蕴结证患者的血清TC、LDL-C含量均高于气滞血瘀证患者(P=0.007; P=0.039),痰瘀蕴结证患者和气滞血瘀证患者的血清TC、LDL-C含量与肾虚血瘀证患者比较,组间差异均无统计学意义(TC:P=0.061,P=0.192; LDL-C:P=0.662,P=0.068); 痰瘀蕴结证患者的血清TG含量高于肾虚血瘀证患者(P=0.040),痰瘀蕴结证患者和肾虚血瘀证患者的血清TG含量与气滞血瘀证患者比较,组间差异均无统计学意义(P=0.407,P=0.367)。结论:股骨头坏死3种中医证型中,痰瘀蕴结证患者的脂代谢与其他2种证候类型患者的脂代谢存在较大差异。
Abstract:
Objective:To compare the lipid metabolism characteristics of patients with three types of TCM syndrome of femur head necrosis(FHN).Methods:Ninety-seven patients with FHN enrolled in the study were classified according to TCM syndrome differentiation,and their blood was drawn from peripheral vein.The serum contents of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein(Apo)-A1 and Apo-B were measured and compared between patients with different types of TCM syndrome of FHN.Results:Phlegm-stagnation syndrome(32 cases),kidney-deficiency-blood-stasis syndrome(45 cases)and qi-stagnation-blood-stasis syndrome(20 cases)were found in the 97 patients.There was no statistical difference in the serum contents of HDL-C,Apo-A1 and Apo-B between the patients with three types of TCM syndrome(HDL-C:0.99+/-0.42,1.14+/-0.34,0.88+/-0.41 mmol/L,F=0.182,P=0.834; Apo-A1:1.18+/-0.27,1.15+/-0.22,1.08+/0.23 g/L,F=0.919,P=0.402; Apo-B:0.84+/-0.22,0.82+/-0.21,0.72+/-0.20 g/L,F=0.167,P=0.846).There was statistical difference in the serum contents of TC,TG and LDL-C between the patients with three types of TCM syndrome(TC:4.77+/-0.97,4.34+/-0.81,4.00+/-1.25 mmol/L,F=6.211,P=0.003; TG:2.13+/-1.49,1.54+/-0.98,1.83+/-1.27 mmol/L,F=3.107,P=0.049; LDL-C:2.95+/-1.01,2.86+/-0.77,2.39+/-1.14 mmol/L,F=3.589,P=0.031).The serum contents of TC and LDL-C were higher in patients with phlegm-stagnation syndrome compared to patients with qi-stagnation-blood-stasis syndrome(P=0.007; P=0.039),and there was no statistical difference in the serum contents of TC and LDL-C between patients with phlegm-stagnation syndrome and patients with kidney-deficiency-blood-stasis syndrome and between patients with qi-stagnation-blood-stasis syndrome and patients with kidney-deficiency-blood-stasis syndrome(TC:P=0.061,P=0.192; LDL-C:P=0.662,P=0.068).The serum contents of TG were higher in patients with phlegm-stagnation syndrome compared to patients with kidney-deficiency-blood-stasis syndrome(P=0.040),and there was no statistical difference in the serum contents of TG between patients with phlegm-stagnation syndrome and patients with qi-stagnation-blood-stasis syndrome and between patients with kidney-deficiency-blood-stasis syndrome and patients with qi-stagnation-blood-stasis syndrome(P=0.407,P=0.367).Conclusion:Lipid metabolism of patients with phlegm-stagnation-type FHN is significantly different from that of patients with kidney-deficiency-blood-stasis-type FHN and patients with qi-stagnation-blood-stasis-type FHN.

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备注/Memo

备注/Memo:
基金项目:广东省中医药局科研项目(20161122)
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更新日期/Last Update: 2019-07-11