[1]陈群群,崔俊英,霍少川,等.3种中医证型股骨头坏死患者的脂代谢特征对比研究[J].中医正骨,2019,31(01):1-4.
 CHEN Qunqun,CUI Junying,HUO Shaochuan,et al.Lipid metabolism characteristics of patients with three types of TCM syndrome of femur head necrosis:a comparative study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(01):1-4.
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3种中医证型股骨头坏死患者的脂代谢特征对比研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年01期
页码:
1-4
栏目:
临床研究
出版日期:
2019-01-20

文章信息/Info

Title:
Lipid metabolism characteristics of patients with three types of TCM syndrome of femur head necrosis:a comparative study
作者:
陈群群1崔俊英2霍少川3何敏聪3
(1.广州中医药大学第三附属医院,广东 广州 510378; 2.广州市越秀区妇幼保健院,广东 广州 510030; 3.广州中医药大学,广东 广州 510405)
Author(s):
CHEN Qunqun1CUI Junying2HUO Shaochuan3HE Mincong3
1.The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510378,Guangdong,China 2.Maternal and Child Health Hospital of Yuexiu District,Guangzhou 510030,Guangdong,China 3.Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,China
关键词:
股骨头坏死 证候 血脂异常 临床试验
Keywords:
femur head necrosis symptom complex dyslipidemias clinical trial
摘要:
目的:比较3种中医证型股骨头坏死患者的脂代谢特征。方法:对符合要求的97例股骨头坏死患者进行中医辨证分型,抽取外周静脉血,测定并对比不同中医证型股骨头坏死患者的血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、载脂蛋白(apolipoprotein,Apo)-A1、Apo -B含量。结果:纳入研究的97例患者中,痰瘀蕴结证32例、肾虚血瘀证45例、气滞血瘀证20例。3种证候类型患者的血清HDL-C、Apo-A1、Apo-B含量比较,差异均无统计学意义[HDL-C:(0.99±0.42)mmol·L-1,(1.14±0.34)mmol·L-1,(0.88±0.41)mmol·L-1,F=0.182,P=0.834; Apo-A1:(1.18±0.27)g·L-1,(1.15±0.22)g·L-1,(1.08±0.23)g·L-1,F=0.919,P=0.402; Apo-B:(0.84±0.22)g·L-1,(0.82±0.21)g·L-1,(0.72±0.20)g·L-1,F=0.167,P=0.846]。3种证候类型患者的血清TC、TG、LDL-C含量比较,差异均有统计学意义[TC:(4.77±0.97)mmol·L-1,(4.34±0.81)mmol·L-1,(4.00±1.25)mmol·L-1,F=6.211,P=0.003; TG:(2.13±1.49)mmol·L-1,(1.54±0.98)mmol·L-1,(1.83±1.27)mmol·L-1,F=3.107,P=0.049; LDL-C:(2.95±1.01)mmol·L-1,(2.86±0.77)mmol·L-1,(2.39±1.14)mmol·L-1,F=3.589,P=0.031]; 痰瘀蕴结证患者的血清TC、LDL-C含量均高于气滞血瘀证患者(P=0.007; P=0.039),痰瘀蕴结证患者和气滞血瘀证患者的血清TC、LDL-C含量与肾虚血瘀证患者比较,组间差异均无统计学意义(TC:P=0.061,P=0.192; LDL-C:P=0.662,P=0.068); 痰瘀蕴结证患者的血清TG含量高于肾虚血瘀证患者(P=0.040),痰瘀蕴结证患者和肾虚血瘀证患者的血清TG含量与气滞血瘀证患者比较,组间差异均无统计学意义(P=0.407,P=0.367)。结论:股骨头坏死3种中医证型中,痰瘀蕴结证患者的脂代谢与其他2种证候类型患者的脂代谢存在较大差异。
Abstract:
Objective:To compare the lipid metabolism characteristics of patients with three types of TCM syndrome of femur head necrosis(FHN).Methods:Ninety-seven patients with FHN enrolled in the study were classified according to TCM syndrome differentiation,and their blood was drawn from peripheral vein.The serum contents of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein(Apo)-A1 and Apo-B were measured and compared between patients with different types of TCM syndrome of FHN.Results:Phlegm-stagnation syndrome(32 cases),kidney-deficiency-blood-stasis syndrome(45 cases)and qi-stagnation-blood-stasis syndrome(20 cases)were found in the 97 patients.There was no statistical difference in the serum contents of HDL-C,Apo-A1 and Apo-B between the patients with three types of TCM syndrome(HDL-C:0.99+/-0.42,1.14+/-0.34,0.88+/-0.41 mmol/L,F=0.182,P=0.834; Apo-A1:1.18+/-0.27,1.15+/-0.22,1.08+/0.23 g/L,F=0.919,P=0.402; Apo-B:0.84+/-0.22,0.82+/-0.21,0.72+/-0.20 g/L,F=0.167,P=0.846).There was statistical difference in the serum contents of TC,TG and LDL-C between the patients with three types of TCM syndrome(TC:4.77+/-0.97,4.34+/-0.81,4.00+/-1.25 mmol/L,F=6.211,P=0.003; TG:2.13+/-1.49,1.54+/-0.98,1.83+/-1.27 mmol/L,F=3.107,P=0.049; LDL-C:2.95+/-1.01,2.86+/-0.77,2.39+/-1.14 mmol/L,F=3.589,P=0.031).The serum contents of TC and LDL-C were higher in patients with phlegm-stagnation syndrome compared to patients with qi-stagnation-blood-stasis syndrome(P=0.007; P=0.039),and there was no statistical difference in the serum contents of TC and LDL-C between patients with phlegm-stagnation syndrome and patients with kidney-deficiency-blood-stasis syndrome and between patients with qi-stagnation-blood-stasis syndrome and patients with kidney-deficiency-blood-stasis syndrome(TC:P=0.061,P=0.192; LDL-C:P=0.662,P=0.068).The serum contents of TG were higher in patients with phlegm-stagnation syndrome compared to patients with kidney-deficiency-blood-stasis syndrome(P=0.040),and there was no statistical difference in the serum contents of TG between patients with phlegm-stagnation syndrome and patients with qi-stagnation-blood-stasis syndrome and between patients with kidney-deficiency-blood-stasis syndrome and patients with qi-stagnation-blood-stasis syndrome(P=0.407,P=0.367).Conclusion:Lipid metabolism of patients with phlegm-stagnation-type FHN is significantly different from that of patients with kidney-deficiency-blood-stasis-type FHN and patients with qi-stagnation-blood-stasis-type FHN.

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备注/Memo:
基金项目:广东省中医药局科研项目(20161122)
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更新日期/Last Update: 2019-07-11