参考文献/References:
[1] 黄宏兴,史晓林,李盛华,等.肌少-骨质疏松症专家共识[J].中国骨质疏松杂志,2022,28(11):1561-1570.
[2] SOLLA-SUAREZ P,ALBERTO A,CARRASCO-SOSA S,et al.Osteosarcopenia and mortality in older adults undergoing transcatheter aortic valve replacement[J].JAMA Cardiol,2024,9(7):611-618.
[3] KIRK B,ZANKER J,DUQUE G,et al.Osteosarcopenia:epidemiology,diagnosis,and treatment-facts and numbers[J].J Cachexia Sarcopenia Muscle,2020,11(3):609-618.
[4] NGUYEN A,LEE P,RODRIGUEZ E K,et al.Addressing the growing burden of musculoskeletal diseases in the ageing US population:challenges and innovations[J].Lancet Healthy Longev,2025,6(5):e25-e35.
[5] FUGGLE N R,RIZZOLI R,REGINSTER J Y,et al.Evidence-based guideline for the management of osteoporosis in men[J].Nat Rev Rheumatol,2024,20(10):626-649.
[6] LEE H Y,TIAN J,NGA H T,et al.Red ginseng extract enhances mitochondrial function and alleviates immunosenescence in T cells[J].J Ginseng Res,2025,49(5):564-573.
[7] SHIRAKAWA T,ONO M,TAKEDA S,et al.Tumor necrosis factor-α regulates myogenesis to inhibit differentiation and promote proliferation in satellite cells[J].Biochem Biophys Res Commun,2021,582(1):35-40.
[8] XU H,BROWN J L,BHASKARAN S,et al.Reactive oxygen species in the pathogenesis of sarcopenia[J].Free Radic Biol Med,2025,227(1):446-458.
[9] RAN D,ZHOU D,LIU G,et al.Reactive oxygen species control osteoblast apoptosis through SIRT1/PGC-1α/P53Lys382 signaling,mediating the onset of Cd-induced osteoporosis[J].J Agric Food Chem,2023,71(15):5991-6002.
[10] SUH J,LEE Y S,BROODRICK J,et al.The multifaceted roles of mitochondria in osteoblasts:from energy production to mitochondrial-derived vesicle secretion[J].J Bone Miner Res,2024,39(9):1205-1216.
[11] MEMBREZ M,MIGLIAVACCA E,CHRISTEN S,et al.Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarco-penia[J].Nat Metab,2024,6(3):433-447.
[12] RAHMAN F A,MCWILLIAMS T G,BUGALLO R,et al.Key considerations for investigating and interpreting auto-phagy in skeletal muscle[J].Autophagy,2024,20(10):2180-2197.
[13] FERRARI S,LANGDAHL B.Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone[J].Nat Rev Rheumatol,2023,19(5):307-317.
[14] SCHURMAN C A,KAYA S,DOLE N,et al.Aging impairs the osteocytic regulation of collagen integrity and bone quality[J].Bone Res,2024,12(1):13.
[15] CARMONA-RIVERA C,LIU Y,KOZIELEC T,et al.Neutrophils in inflammatory bone diseases[J].Curr Osteoporos Rep,2024,22(3):205-221.
[16] SÁNCHEZ-SÁNCHEZ J L,GÓMEZ-CABRERA M C,LORENZO-CALVO J,et al.Association of physical behaviours with sarcopenia in older adults[J].Lancet Healthy Longev,2024,5(9):e606-e616.
[17] ZHANG Y,LIU T,XU Z,et al.Fiber type-specific atrophy in sarcopenia:mechanisms and functional consequences[J].J Cachexia Sarcopenia Muscle,2022,13(5):2542-2556.
[18] SHIGEHARA K,KATO Y,IZUMI K,et al.Relationship between testosterone and sarcopenia in older-adult men:a narrative review[J].World J Mens Health,2022,40(4):522-537.
[19] ZHONG Q,ZHANG Q,WANG L,et al.Post-translational regulation of muscle growth and wasting:implications for sarcopenia and cachexia[J].J Cachexia Sarcopenia Muscle,2023,14(3):1212-1227.
[20] PENNIMAN C M,BHARDWAJ G,NOWERS C J,et al.Loss of FoxOs in muscle increases strength and mitochondrial function during aging[J].J Cachexia Sarcopenia Muscle,2023,14(1):243-259.
[21] CROMBIE E M,COWBURN A S,POTTER P,et al.Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity[J].J Cachexia Sarcopenia Muscle,2023,14(1):198-213.
[22] SOUSA-VICTOR P,GARCÍA-PRAT L,MUÑOZ-CÁNOVES P,et al.Control of satellite cell function in muscle regeneration and disease[J].Nat Rev Mol Cell Biol,2022,23(9):641-659.
[23] LI G,ZHANG L,WANG D,et al.Muscle-bone crosstalk and potential therapies for sarco-osteoporosis[J].J Cell Biochem,2019,120(9):14262-14273.
[24] DONG Y,WU C,ZHANG L,et al.Bone-muscle crosstalk under physiological and pathological conditions[J].Cell Mol Life Sci,2024,81(1):310.
[25] DONG Q,LI D,ZHANG K,et al.Muscle-bone biochemical crosstalk in osteosarcopenia:focusing on mechanisms and potential therapeutic strategies[J].J Endocrinol,2025,266(3):e250234.
[26] LIU J,WANG Z,ZHANG C,et al.M2 macrophage-derived exosomal miR-486-5p influences the differentiation potential of BMMSCs via the SMAD2/TGF-β pathway[J].Aging(Albany NY),2023,15(18):9499-9520.
[27] MA S,XING X,HUANG H,et al.Skeletal muscle-derived extracellular vesicles transport glycolytic enzymes to mediate muscle-to-bone crosstalk[J].Cell Metab,2023,35(11):2028-2043.
[28] 朱世壮,杨大志.外泌体与骨质疏松相关研究进展[J].中国骨质疏松杂志,2022,28(6):912-915.
[29] KARSENTY G.Osteocalcin:a multifaceted bone-derived hormone[J].Annu Rev Nutr,2023,43(1):55-71.
[30] HU X,WANG Z,WANG W,et al.Irisin as an agent for protecting against osteoporosis:a review of the current mechanisms and pathways[J].J Adv Res,2024,62:175-186.
[31] SNYDER P,BAUER D C,ELLENBERG S S,et al.Testosterone treatment and fractures in men with hypogonadism[J].N Engl J Med,2024,390(3):203-211.
[32] GIUSTINA A,BILEZIKIAN J P,ADLER R A,et al.Consensus statement on vitamin D status assessment and supplementation:whys,whens,and hows[J].Endocr Rev,2024,45(5):625-654.
[33] LI Y,SHI Z,ZHANG X,et al.Metagenomic analysis re-vealing links between age,gut microbiota and bone loss in Chinese adults[J].NPJ Metab Health Dis,2025,3(1):18-26.
[34] LAHIRI S,KIM H,GARCIA-PEREZ I,et al.The gut microbiota influences skeletal muscle mass and function in mice[J].Sci Transl Med,2019,11(502):eaan5662.
[35] CONN M O,DEJONG E N,MARKO D M,et al.Microbiota protect against frailty and loss of skeletal muscle,and maintain inflammatory tone during aging in mice[J].Am J Physiol Cell Physiol,2025,328(3):C887-C894.
[36] ZHAO F,GUO Z,KWOK L Y,et al.Bifidobacterium lactis Probio-M8 improves bone metabolism in patients with postmenopausal osteoporosis,possibly by modulating the gut microbiota[J].Eur J Nutr,2023,62(2):965-976.
[37] WEIVODA M M,BRADLEY E W.Macrophages and bone remodeling[J].J Bone Miner Res,2023,38(3):359-369.
[38] HAACKE J,SENDECKI R S,BURGOLD S,et al.Innate immune training of osteoclastogenesis promotes inflammatory bone loss[J].Dev Cell,2025,60(13):1854-1870.
[39] LI W,ZHANG Z,KUMAR S,et al.Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination[J].Nat Aging,2025,5(4):607-621.
[40] FARR J N,ATKINSON E J,ACHENBACH S J,et al.Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women:a phase 2 randomized controlled trial[J].Nat Med,2024,30(9):2605-2612.
[41] KOK H J,FLETCHER D B,OSTER J C,et al.Transcriptomics reveals transient and dynamic muscle fibrosis and atrophy differences following spinal cord injury in rats[J].J Cachexia Sarcopenia Muscle,2024,15(4):1309-1323.
[42] LIU Z T,LIU M H,XIONG Y,et al.Crosstalk between bone and brain in Alzheimer's disease:mechanisms,applications,and perspectives[J].Alzheimers Dement,2024,20(8):5720-5739.
[43] BENARROCH E.What is the role of the sympathetic system in skeletal muscle?[J].Neurology,2024,102(10):e209488.
[44] TREYBALL A,BERGERON A C,BROOKS D J,et al.Propranolol promotes bone formation and limits resorption through novel mechanisms during anabolic parathyroid hormone treatment in female C57BL/6J mice[J].J Bone Miner Res,2022,37(5):954-971.
[45] ROSEN C J,HOROWITZ M C.Nutrient regulation of bone marrow adipose tissue:skeletal implications of weight loss[J].Nat Rev Endocrinol,2023,19(11):626-638.
[46] TIAN L,LU L,MENG Y,et al.Bone marrow stromal stem cell fate decision:a potential mechanism for bone marrow adipose increase with aging-related osteoporosis[J].Curr Mol Med,2023,23(10):1046-1057.
[47] ZHOU R,GUO Q,XIAO Y,et al.Endocrine role of bone in the regulation of energy metabolism[J].Bone Res,2021,9(1):25.
[48] WANG L,VALENCAK T G,SHAN T,et al.Fat infiltration in skeletal muscle:influential triggers and regulatory mechanism[J].iScience,2024,27(3):109221.
[49] ZHANG X,TIAN L,MAJUMDAR A,et al.Function and regulation of bone marrow adipose tissue in health and disease:state of the field and clinical considerations[J].Compr Physiol,2024,14(3):5521-5579.
[50] XIA W,VEERAGANDHAM P,CAO Y,et al.Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation[J].Nat Metab,2024,6(1):273-289.
相似文献/References:
[1]李林军.应用膨胀式椎弓根螺钉内固定治疗合并骨质疏松的
胸腰椎退行性疾病[J].中医正骨,2015,27(08):49.
[2]韩艳,温利平,刘娜,等.补肾活血方对去卵巢大鼠骨代谢及骨密度的影响[J].中医正骨,2015,27(12):7.
HAN Yan,WEN Liping,LIU Na,et al.Effect of Bushen Huoxue Fang(补肾活血方)on bone metabolism and bone mineral density in the ovariectomized rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(01):7.
[3]李学朋,朱立国.骨疏康胶囊对去卵巢大鼠骨小梁的影响[J].中医正骨,2015,27(12):12.
LI Xuepeng,ZHU Liguo.Effect of Gushukang Jiaonang(骨疏康胶囊)on bone trabecula in the ovariectomized rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(01):12.
[4]陈冠军,陈扬,庄汝杰.可灌注骨水泥椎弓根螺钉系统
在老年腰椎疾患手术中的应用[J].中医正骨,2015,27(02):40.
[5]王丹辉,贲越,韩梅.林蛙油治疗绝经后骨质疏松症的临床研究[J].中医正骨,2014,26(01):27.
Wang Danhui*,Ben Yue,Han Mei..Clinical study of Rana temporaria oil in the treatment of postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(01):27.
[6]黄建华,黄建武,李慧辉,等.加味左归丸对绝经后骨质疏松症肝肾不足证
患者骨密度的影响[J].中医正骨,2013,25(11):19.
Huang Jianhua*,Huang Jianwu,Li Huihui,et al.Effect of JIAWEI ZUOGUI pill on bone mineral density in postmenopausal osteoporosis patients with deficiency of liver and kidney[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(01):19.
[7]项旻,杨虹,林爱菊,等.绝经后2型糖尿病患者骨质疏松与血微量元素的关系研究[J].中医正骨,2013,25(12):20.
Xiang Min*,Yang Hong,Lin Aiju,et al.Clinical study on the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(01):20.
[8]史晓林,李春雯,张志强.弱阳离子磁珠分离技术和基质辅助激光解吸电离飞行时间质谱技术在原发性Ⅰ型骨质疏松症血清标志蛋白筛选中的应用[J].中医正骨,2014,26(03):5.
Shi Xiaolin*,Li Chunwen,Zhang Zhiqiang..Application of magnetic beads based weak cation exchange separation technology and matrix-assisted laser desorption-ionization time of flight mass spectrometry technology in screening serum protein markers of primary type-Ⅰ osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(01):5.
[9]李明,徐明雄,冯左基,等.自拟壮骨方治疗绝经后骨质疏松症的疗效及作用机制研究[J].中医正骨,2014,26(09):21.
Li Ming*,Xu Mingxiong,Feng Zuoji,et al.Study on the curative effect and mechanism of action of self-made ZHUANGGU decoction in treatment of postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(01):21.
[10]陈俊杰,李晴晴,夏瑢.脂代谢及血清内脂素水平与绝经后骨质疏松症的
相关性研究[J].中医正骨,2012,24(04):16.
CHEN Jun-jie*,LI Qing-qing,XIA Rong.*.Study on the correlations between the levels of lipid metabolism and serum visfatin and postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(01):16.
[11]李嘉彤,李念虎.基于“脾肾-营卫-络脉”理论论治肌少-骨质疏松症[J].中医正骨,2024,36(03):74.