[1]余阳,陈天鹏,何才剑,等.补体成分3与骨质疏松症关系的研究进展[J].中医正骨,2021,33(02):69-71.
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补体成分3与骨质疏松症关系的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第33卷
期数:
2021年02期
页码:
69-71
栏目:
综述
出版日期:
2021-02-20

文章信息/Info

作者:
余阳1陈天鹏1何才剑1李少华1袁一峰1史晓林2唐彬彬2吴连国2梁博程2刘康2
(1.浙江中医药大学第二临床医学院,浙江 杭州 310053; 2.浙江中医药大学附属第二医院,浙江 杭州 310005)
关键词:
骨质疏松 补体C3 骨代谢 综述
摘要:
骨质疏松症是老年人常见病,目前相关研究证实骨质疏松症与免疫系统之间存在联系,骨保护素(osteoprotegrin,OPG)/核因子κB受体活化因子配体(receptor activator of nuclear factor-κB ligand,RANKL)/核因子κB受体活化因子(receptor activator of nuclear factor-κB,RANK)信号通路是连接二者的关键通路。补体系统是重要的免疫系统,补体成分3在补体系统中占据重要地位。研究表明,补体成分3与骨质疏松症之间存在密切关系。开展补体成分3及其他免疫系统成分与骨质疏松症关系的研究,有助于为骨质疏松症的诊治提供新的方向。本文简要概述了补体系统,分析了OPG/RANKL/RANK信号通路在骨质疏松症发生发展中的作用机制,就补体成分3及其他免疫系统成分与骨质疏松症的关系的研究进展进行了综述。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(81973884); 浙江省自然科学基金项目(LY19H290004)
通讯作者:刘康 E-mail:Liukang1982@163.com
更新日期/Last Update: 2021-02-20