[1]张高魁,郝阳泉,许鹏,等.基于西安市红会医院股骨头坏死数据库分析酒精性股骨头坏死患者的特征[J].中医正骨,2020,32(09):35-38.
　ZHANG GaoKui,HAO Yangquan,XU Peng,et al.Analysis of the characteristics of patients with alcohol-induced osteonecrosis of the femoral heads(ONFH)based on Xi’an Honghui Hospital ONFH database[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2020,32(09):35-38.
点击复制

基于西安市红会医院股骨头坏死数据库分析酒精性股骨头坏死患者的特征()
分享到：

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第32卷
期数:
2020年09期
页码:
35-38
栏目:
调查研究
出版日期:
2020-09-20

文章信息/Info

Title:
Analysis of the characteristics of patients with alcohol-induced osteonecrosis of the femoral heads(ONFH)based on Xi’an Honghui Hospital ONFH database
作者:
张高魁1; 郝阳泉2;  许鹏2; 王秋霞1; 李欢欢1; 胡守业2; 鲁超2
(1.陕西中医药大学附属医院,陕西 咸阳 712000; 2.西安交通大学附属红会医院,陕西 西安 710054)
Author(s):
ZHANG GaoKui1; HAO Yangquan2; XU Peng2; WANG Qiuxia1; LI Huanhuan1; HU Shouye2; LU Chao2
1.The Affiliated Hospital of Shanxi University of Chinese Medicine,Xianyang 712000,Shanxi,China2.Honghui Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710054,Shanxi,China
关键词:
股骨头坏死;  酒精性饮料;  流行病学研究;  数据库
Keywords:
femur head necrosis;  alcoholic beverages;  epidemiologic studies;  database
摘要:
目的:分析酒精性股骨头坏死患者的特征。方法:从西安市红会医院股骨头坏死数据库(http://ggt.keyanyun.com/index.php/login)中选择2014年1月至2017年12月就诊的酒精性股骨头坏死患者的病例资料进行分析,包括性别、年龄、职业、文化程度、体质量指数、发病侧别、病程(出现症状至确诊为股骨头坏死的时间)、ARCO分期、首次就诊医院等级、饮酒史、每周饮酒量、每周饮酒次数、日常饮酒(500 mL)价格和饮酒种类等信息。结果:①基本情况。2014年1月至2017年12月在西安交通大学医学院附属红会医院就诊的非创伤性股骨头坏死患者共1062例,其中酒精性股骨头坏死患者306例,最终纳入256例。以男性患者为主,男255例(99.61%)、女1例(0.39%); 年龄多为41～60岁,其中41～50岁56例(21.88%)、51～60岁172例(67.19%); 职业为农民的患者121例(47.27%),职员和工人各37例(14.45%); 文化程度以高中及以下文化程度为主,其中高中66例(25.78%)、初中76例(29.69%)、小学72例(28.13%); 体质量正常(18.5 kg·m-2≤体质量指数<25 kg·m-2)的患者186例(72.66%),肥胖前期(25 kg·m-2≤体质量指数<30 kg·m-2)的患者55例(21.48%)。②发病情况。双侧发病患者17例(69.92%); 病程多在6个月以内,其中病程≤3个月的患者105例(41.02%)、病程4～6个月的患者69例(26.95%); ARCO分期多属中晚期,其中Ⅲ期180髋(41.38%)、Ⅳ期138髋(31.72%); 首次就诊医院为一级医院的患者97例(37.89%),三级医院的患者123例(48.05%)。③饮酒情况。饮酒史16～20年的患者93例(36.33%),饮酒史6～10年的患者66例(25.78%); 每周饮酒量≤500 mL的患者139例(54.30%,中位数400 mL),每周饮酒量501～1000 mL的患者55例(21.48%); 每周饮酒2次的患者132例(51.56%),每周饮酒3次的患者51例(19.92%),每周饮酒4次的患者27例(10.55%); 日常饮酒价格多低于120元,其中饮酒价格≤15元的患者82例(32.03%)、16～30元的患者68例(26.56%)、31～60元的患者27例(10.55%)、61～90元的患者32例(12.50%)、91～120元的患者31例(12.11%); 饮酒种类以白酒和啤酒为主,其中饮用白酒的患者169例(66.02%)、饮用啤酒的患者28例(10.94%)、饮用白酒和啤酒的患者56例(21.88%)。结论:酒精性股骨头坏死患者的特征包括,以41～60岁的男性体力劳动者多见、以高中及以下文化程度为主、体质量多正常、多有6～20年的饮酒史、每周饮酒2～4次、每周饮酒量多>400 mL、日常饮酒(500 mL)价格多低于120元、饮酒种类以白酒和啤酒为主、多为双侧发病、病程多≤6个月、就诊时病情多已进展至中晚期(ARCOⅢ、Ⅳ期)。
Abstract:
To analyze the characteristics of patients with alcohol-induced ONFH.Methods:The medical records of patients with alcohol-induced ONFH who were treated in Honghui Hospital Affiliated to Medical College of Xi’an Jiaotong University from January 2014 to December 2017 were selected out from Xi’an Honghui Hospital ONFH database(http://ggt.keyanyun.com/index.php/login),and the patients’ information,including gender,age,occupation,education degree,body mass index(BMI),onset side,disease course,ARCO stage,first-visit hospital grade,alcohol-drinking history,weekly alcohol consumption,weekly drinking times,daily alcohol-drinking(500 mL)price and type,were extracted from their medical records and were analyzed.Results:A total of 1062 non-traumatic ONFH patients were treated in Honghui Hospital Affiliated to Medical College of Xi’an Jiaotong University from January 2014 to December 2017,in which 306 cases with alcohol-induced ONFH were found.After screening,256 cases were included in the final analysis.The patients include 255 males(99.61%)and 1 female(0.39%),and mainly ranged in age from 41 to 50 years(56 cases,21.88%)and 51 to 60 years(172 cases,67.19%).Their occupation were mainly farmers(121 cases,47.27%),employees(37 cases,14.45%)and workers(37 cases,14.45%),and education degrees were mainly senior high school(66 cases,25.78%),junior high school(76 cases,29.69%)and primary school(72 cases,28.13%).There were 186(72.66%)patients with normal BMI(18.5 kg/m(2)≤BMI<25 kg/m(2)),and 55(21.48%)pre-obese(25 kg/m(2)≤BMI<30 kg/m(2))patients.Most patients(179 cases,69.92%)got bilateral ONFH and the disease courses were less than 3 months in 105 cases(41.02%)and ranged from 4 to 6 months in 69 cases(26.95%).The ONFH mainly belonged to ARCO phaseⅢ(180 hips,41.38%)and phase Ⅳ(138 hips,31.72%)and the patients were firstly treated in first-grade hospitals(97 cases,37.89%)and third-grade hospitals(123 cases,48.05%).The alcohol-drinking history ranged from 16 to 20 years in 93 cases(36.33%)and ranged from 6 to 10 years in 66 cases(25.78%).The weekly alcohol consumption were less than 500 mL(Median=400 mL)in 139 cases(54.30%)and ranged from 501 to 1000 mL in 55 cases(21.48%).The frequency of drinking alcohol were twice a week in 132 cases(51.56%),three times a week in 51 cases(19.92%)and four times a week in 27 cases(10.55%).The prices of daily alcohol-drinking were mostly lower than 120 RMB.The alcohol-drinking prices ranged from 1 to 15 RMB for 82 cases(32.03%),16 to 30 RMB for 68 cases(26.56%),31 to 60 RMB for 27 cases(10.55%),61 to 90 RMB for 32 cases(12.50%)and 91 to 120 RMB for 31 cases(12.11%).The drink were mainly white spirits and beer.and 169 cases(66.02%)drank white spirit,28 cases(10.94%)drank beer and 56 cases(21.88%)drank white spirits and beer.Conclusion:The patients with alcohol-induced ONFH are mainly characterized by male manual workers aged from 41 to 60 years,senior high school education and below,normal BMI,6-20 years of alcohol-drinking history,2-4 times of weekly drinking,>400 mL of weekly alcohol consumption,<120 RMB of daily alcohol-drinking(500 mL,mainly include white spirits and beer),bilateral onset,≤6 months of disease course and ARCO phaseⅢandⅣ.

参考文献/References:

[1] 周占国,郭浩山,关涛,等.股骨头坏死病因的相关因素分析[J].中医正骨,2020,32(1):7-10.
[2] 何伟,刘予豪,周驰,等.非手术保髋治疗非创伤性股骨头坏死的临床研究[J].中国中西医结合杂志,2020,40(2):176-181.
[3] ROTH A,BECKMANN J,BOHNDORF K,et al.S3-Guideline non-traumatic adult femoral head necrosis[J].Arch Orthop Trauma Surg,2016,136(2):165-174.
[4] YOON B H,KIM T Y,SHIN I S,et al.Alcohol intake and the risk of osteonecrosis of the femoral head in Japanese populations:a dose-response meta-analysis of case-control studies[J].Clin Rheumatol,2017,36(11):2517-2524.
[5] 陈志伟,王振涛,李泰贤,等.酒精相关性股骨头坏死的发病特征分析[J].中医正骨,2017,29(12):23-25.
[6] 谢斌,张小磊,王荣田,等.酒精性股骨头坏死的发病特点分析[J].中国医刊,2015,50(11):48-50.
[7] 李子荣.股骨头坏死临床诊疗规范[J].中华骨与关节外科杂志,2015,387(1):1-6.
[8] 中华医学会骨科分会显微修复学组,中国修复重建外科专业委员会骨缺损及骨坏死学组.成人股骨头坏死诊疗标准专家共识(2012年版)[J].中华骨科杂志,2012,32(6):606-610.
[9] SAITO M,UESHIMA K,ISHIDA M,et al.Alcohol-associated osteonecrosis of the femoral head with subsequent development in the contralateral hip:a report of two cases[J].J Orthop Sci,2016,21(6):870-874.
[10] 张恩景,廖文,蔡进奎,等.非创伤性股骨头坏死的基因多态性研究进展[J].中国骨质疏松杂志,2018,24(4):543-546.
[11] KANEKO S,TAKEGAMI Y,SEKI T,et al.Surgery trends for osteonecrosis of the femoral head:a fifteen-year multi-centre study in Japan[J].Int Orthop,2020,44(4):761-769.
[12] KANG J S,PARK S,SONG J H,et al.Prevalence of osteonecrosis of the femoral head:a nationwide epidemiologic analysis in Korea[J].J Arthroplasty,2009,24(8):1178-1183.
[13] CUI L,ZHUANG Q,LIN J,et al.Multicentric epidemiologic study on six thousand three hundred and ninety five cases of femoral head osteonecrosis in China[J].Int Orthop,2016,40(2):267-276.
[14] SONG Y,DU Z,REN M,et al.Significant associations of SOX9 gene polymorphism and gene expression with the risk of osteonecrosis of the femoral head in a Han population in northern China[J/OL].Biomed Res Int,2016[2020-02-01].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174161.
[15] 王秋霞,史传道,张高魁,等.基于股骨头坏死数据库分析成人股骨头坏死误诊相关因素[J].临床误诊误治,2020,33(2):4-9.
[16] 赵岩,沈计荣,张超,等.股骨头坏死保髋手术治疗现状[J].中医正骨,2020,32(1):47-50.
[17] YANG S Y,ZENG L Y,LI C,et al.Correlation between an ABO blood group and primary femoral head necrosis:a case-control study[J].Orthop Surg,2020,12(2):450-456.
[18] LARSON E,JONES L C,GOODMAN S B,et al.Early-stage osteonecrosis of the femoral head:where are we and where are we going in year 2018?[J].Int Orthop,2018,42(7, SI):1723-1728.
[19] 范亚楠,李文龙,张颖,等.不同病因股骨头坏死的ARCO分期和中日友好医院分型特征研究[J].中医正骨,2020,32(1):25-27.
[20] 许珂,宇文星,宋梦歌,等.股骨头坏死全髋关节置换术患者的人群特征与临床特点分析[J].中医正骨,2020,32(1):51-55.
[21] YOON B H,JONES L C,CHEN C H,et al.Etiologic classification criteria of ARCO on femoral head osteonecrosis part 2:alcohol-associated osteonecrosis[J].J Arthroplasty,2019,34(1):169-174.
[22] 闫洪雨.哈尔滨市区龙江产白酒市场现状及质量研究[D].哈尔滨:黑龙江大学,2014.
[23] 刘回春.白酒价格几元到千元区别究竟在哪里[J].中国质量万里行,2016(10):37-38.
[24] LIN Z,LIN Y S.Identification of potential crucial genes associated with steroid-induced necrosis of femoral head based on gene expression profile[J].Gene,2017,627:322-326.
[25] LIU C,AN F M,CAO Y,et al.Significant association between RETN genetic polymorphisms and alcohol-induced osteonecrosis of femoral head[J].Mol Genet Genomic Med,2019,7(8):e822.

相似文献/References:

[1]陈雷雷,张颖.何伟教授采用中医药疗法治疗股骨头坏死的经验[J].中医正骨,2015,27(10):74.
[2]徐西林,赵永兰,张晓峰,等.活骨注射液髋关节腔灌注对兔股骨头坏死模型 血管内皮生长因子表达的动态影响[J].中医正骨,2015,27(08):1.
　XU Xilin,ZHAO Yonglan,ZHANG Xiaofeng,et al.Dynamic effect of intra-articular hip injection of Huogu injection on the expression of vascular endothelial growth factor in rabbit models with femur head necrosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):1.
[3]周勇,任菲菲,丰凡翔,等.血管内皮生长因子和骨形态发生蛋白2 在非创伤性股骨头坏死不同区域的表达[J].中医正骨,2015,27(08):7.
　ZHOU Yong,REN Feifei,FENG Fanxiang,et al.Expressions of vascular endothelial growth factor and bone morphogenetic protein 2 in different zones of femoral head with non-traumatic osteonecrosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):7.
[4]鲍荣华,王国平,夏晓斌,等.钽棒植入治疗非创伤性股骨头坏死的疗效观察[J].中医正骨,2015,27(02):28.
[5]张兵,马凰富,刘波,等.非创伤性股骨头坏死的舌象定量研究[J].中医正骨,2015,27(04):8.
　ZHANG Bing,MA Huangfu,LIU Bo,et al.Quantitative study on tongue manifestation of patients with nontraumatic osteonecrosis of femoral head[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):8.
[6]李刚,程春生.股骨头坏死血瘀证症状与平乐郭氏正骨方药药物组成 最大频繁关联模式挖掘[J].中医正骨,2015,27(04):21.
　LI Gang,CHENG Chunsheng.Maximal frequent association pattern mining for studying the relationship between BLOOD STASIS syndrome in patients with osteonecrosis of femoral head and drug components of Pingle Guo's orthopedics prescription[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(09):21.
[7]李文龙,梅沉成,杜贵强,等.微创减压植骨多孔钽棒植入治疗 ARCOⅡ期非创伤性缺血性股骨头坏死[J].中医正骨,2016,28(02):43.
[8]张磊,金红婷,童培建.骨健口服液早期干预非创伤性股骨头坏死的临床研究[J].中医正骨,2016,28(03):14.
　ZHANG Lei,JIN Hongting,TONG Peijian.Clinical study on Gujian Koufuye(骨健口服液)for early intervention of nontraumatic osteonecrosis of femoral head[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(09):14.
[9]鲍荣华,王国平,夏晓斌,等.直接前入路微创全髋关节置换术治疗晚期股骨头坏死[J].中医正骨,2016,28(03):61.
[10]张超,姚晨,沈计荣.微创髓芯减压打压支撑植骨术结合补肾活血汤口服治疗ARCOⅡ、Ⅲ期股骨头坏死的近期疗效观察[J].中医正骨,2016,28(03):20.
　ZHANG Chao,YAO Chen,SHEN Jirong.[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(09):20.

备注/Memo

备注/Memo:
基金项目:中国博士后科学基金项目(2017M613179); 陕西省长安郭氏骨伤学术流派工作室建设项目(陕中医药发[2018]40号)
通讯作者:鲁超 E-mail:luchao0925@163.com
更新日期/Last Update: 2020-09-20