[1]孙艳,陈立忠,王海燕,等.增液润节汤和美洛昔康片治疗膝骨关节炎的对比研究[J].中医正骨,2014,26(01):21-23.
　Sun Yan*,Chen Lizhong,Wang Haiyan,et al.A retrospective trial of ZENGYERUNJIE decoctions versus Meloxicam tablets in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(01):21-23.
点击复制

增液润节汤和美洛昔康片治疗膝骨关节炎的对比研究()
分享到：

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期数:
2014年01期
页码:
21-23
栏目:
骨关节炎
出版日期:
2014-01-28

文章信息/Info

Title:
A retrospective trial of ZENGYERUNJIE decoctions versus Meloxicam tablets in the treatment of knee osteoarthritis
作者:
孙艳; 陈立忠; 王海燕; 孙海东
中国人民解放军第208医院,吉林 长春 130062
Author(s):
Sun Yan*; Chen Lizhong; Wang Haiyan; Sun Haidong.
* The 208th hospital of PLA,Changchun 130062,Jilin,China
关键词:
骨关节炎; 膝 消炎药; 非甾类 治疗; 临床研究性 增液润节汤
Keywords:
Osteoarthritis; knee;  Anti-inflammatory agents; non-steroidal;  Therapies; investigational;  ZENGYERUNJIE decoctions
摘要:
目的:对比增液润节汤和美洛昔康片治疗膝骨关节炎的临床疗效和安全性。方法:膝骨关节炎患者100例,随机分为2组,每组50例。治疗组口服增液润节汤,对照组口服美洛昔康片,共治疗2个月。观察2组患者症状缓解、关节功能改善及不良反应发生情况,并对2组患者的疗效和不良反应发生率进行比较。结果:治疗前2组患者Lequesne指数评分比较,差异无统计学意义[(12.40±1.51)分,(11.85±1.75)分; t=1.683,P=0.097)]; 治疗2个月后,2组患者症状缓解、患膝功能改善,Lequesne指数评分均下降,2组间比较差异有统计学意义[(6.82±1.64)分,(8.47±1.82)分; t=4.790,P=0.000]; 且治疗组下降程度更明显[(5.58±1.62)分,(3.38±1.36)分; t=7.355,P=0.000]。参照中药新药治疗骨性关节炎的临床研究指导原则中的疗效判定标准评价疗效,治疗组临床控制11例、显效27例、有效11例、无效1例; 对照组临床控制6例、显效23例、有效12例、无效9例; 治疗组疗效优于对照组,差异有统计学意义(Z=-2.338,P=0.019)。治疗期间,治疗组出现胃肠道反应2例,肝功能异常1例; 对照组出现胃肠道反应8例,心动过速2例,肝功能异常4例,白细胞下降2例,血肌酐增高3例。经对症处理后,2组患者不良反应均消失。2组患者不良反应发生率比较,差异有统计学意义(χ2=14.918,P=0.000)。结论:采用增液润节汤和美洛昔康片治疗膝骨关节炎,均可有效缓解症状、改善患膝功能; 但增液润节汤疗效优于美洛昔康片,且不良反应较少,更安全可靠。
Abstract:
Objective:To compare ZENGYERUNJIE decoctions and Meloxicam tablets in the clinical curative effects and safety for knee osteoarthritis(KOA).Methods:One hundred patients with KOA enrolled in the trial were randomly divided into 2 groups,50 cases in each group.Patients in treatment group were administrated with oral application of ZENGYERUNJIE decoctions,while the others in control group were administrated with oral application of Meloxicam tablets.The total disease course was 2 months.The symptoms relief,joint function improvement and adverse reactions were observed,and the curative effects and incidence rate of adverse reactions were compared between the 2 groups.Results:There was no statistical difference in the Lequesne indices scores between the 2 groups before the treatment(12.40+/-1.51 vs 11.85+/-1.75 points; t=1.683,P=0.097).After two-month treatment,the symptoms were relieved and the knee function were improved and the Lequesne indices scores decreased.There was statistical difference in Lequesne indices scores between the 2 groups(6.82+/-1.64 vs 8.47+/-1.82 points; t=4.790,P=0.000),and the decreased degree was bigger in treatment group compared to control group(5.58+/-1.62 vs 3.38+/-1.36 points,t=7.355,P=0.000).The curative effects were evaluated in accordance with the criterion in Guiding principles of clinical research on new Chinese medicine for osteoarthritis.Eleven patients got an excellent result,27 good,11 fair,and 1 poor in the treatment group,while 6 patients got an excellent result,23 good,12 fair,and 9 poor in the control group.The treatment group surpassed the control group in the clinical effect and there was statistical difference between the 2 groups(Z=-2.338,P=0.019).During the treatment,gastrointestinal reactions(2 patients)and transient liver dysfunction(1 patients)were found in the treatment group; while gastrointestinal reactions(8 patients),tachycardia(2 patients),transient liver dysfunction(4 patients),white blood cells(WBC)decrease(2 patients)and serum creatinine increase(3 patients)were found in the control group.Adverse reactions disappeared after symptomatic treatment in both of the 2 groups.There was statistical difference in incidence rate of adverse reaction between the 2 groups(χ2=14.918,P=0.000).Conclusion:In the treatment of KOA,oral application of both ZENGYERUNJIE decoctions and Meloxicam tablets can effectively relieve the symptoms and improve the knee function.However,the ZENGYERUNJIE decoctions surpassed the Meloxicam tablets in the clinical effect with less adverse reactions.

参考文献/References:

[1] 丁田机.按摩治疗膝骨关节炎40例疗效分析[J].按摩与康复医学,2012,2(2):78-79.
[2] 刘献祥.中医药治疗膝骨性关节炎的研究现状[J].中医正骨,2012,24(1):3-7.
[3] 中华医学会骨科学分会.骨关节炎诊治指南(2007年版)[J].中华骨科杂志,2007,27(10):793-796.
[4] 吴昭克,朱勇,李艺彬,等.壮骨通痹丸与硫酸氨基葡萄糖治疗膝骨关节炎的比较研究[J].中医正骨,2012,24(7):20-22.
[5] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中医药科技出版社,2002:349-353.
[6] Benito MJ,Veale DJ,FitzGerald O,et al.Synovial tissue inflammation in early and late osteoarthritis[J].Ann Rheum Dis,2005,64(9):1263-1267.
[7] Rollín R,Marco F,Jover JA,et al.Early lymphocyte activation in the synovial microenvironment in patients with osteoarthritis:comparison with rheumatoid arthritis patients and healthy controls[J].Rheumatol Int,2008,28(8):757-764.

相似文献/References:

[1]孟维娜,明立功,王新德,等.关节镜下清理联合腓骨近1/3段截骨治疗膝骨关节炎[J].中医正骨,2015,27(11):40.
[2]明立功,孟维娜,王新德,等.腓骨近端截骨治疗内侧间室膝骨关节炎的近期疗效观察[J].中医正骨,2015,27(10):25.
[3]张杰,王人彦,张玉柱.膝骨关节炎的治疗进展[J].中医正骨,2015,27(10):68.
[4]梁朝,蔡静怡,闫立,等.针刀疗法改善膝骨关节炎早期疼痛症状的疗效评价[J].中医正骨,2015,27(09):9.
　LIANG Zhao,CAI Jingyi,YAN Li,et al.Evaluation of the curative effect of needle-knife therapy for relieving knee pain in patients with early knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(01):9.
[5]王建武,党建军,李强,等.四联疗法治疗膝骨关节炎[J].中医正骨,2015,27(08):44.
[6]刘红娟,郭会利,郭树农.云克联合中药治疗膝骨关节炎的护理[J].中医正骨,2015,27(08):75.
[7]陈卫衡.探索建立系统的膝骨关节炎中医临床科研范式 和理论体系[J].中医正骨,2015,27(07):1.
[8]郑春松,叶蕻芝,李西海,等.透骨消痛胶囊中补肾柔肝药和活血祛风药治疗 骨关节炎作用方式的计算机模拟比较[J].中医正骨,2015,27(07):6.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Comparison of the mode of action of Bushen Rougan(补肾柔肝)drugs versus Huoxue Qufeng(活血祛风)drugs contained in Tougu Xiaotong Jiaonang(透骨消痛胶囊)for the treatment of osteoarthritis:A computer simulation study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(01):6.
[9]帅波,沈霖,杨艳萍,等.加味青娥丸治疗膝骨关节炎的作用机制研究[J].中医正骨,2015,27(07):15.
　SHUAI Bo,SHEN Lin,YANG Yanping,et al.Study on the mechanism of action of Jiawei Qing'e Wan(加味青娥丸)for the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(01):15.
[10]梅其杰,袁长深,段戡,等.壮药骨痹方烫熨联合运动疗法治疗膝骨关节炎的临床研究[J].中医正骨,2015,27(07):27.
　MEI Qijie,YUAN Changshen,DUAN Kan,et al.Clinical study of the curative effect of hot compressing and rubbing with packet of Gubi Fang(骨痹方)combined with exercise therapy in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(01):27.

更新日期/Last Update: 2014-01-20