[1]卢建华,王维佳,陈明涛,等.补肾方对去卵巢大鼠腰椎骨形态计量学的影响[J].中医正骨,2011,23(05):24-26.
　LU Jian-hua*,WANG Wei-jia,CHEN Ming-tao,et al.Effect of BuShenfang on morphometry of lumbar vertebra in Ovariectomized Rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(05):24-26.
点击复制

补肾方对去卵巢大鼠腰椎骨形态计量学的影响()
分享到：

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第23卷
期数:
2011年05期
页码:
24-26
栏目:
基础研究
出版日期:
2011-05-30

文章信息/Info

Title:
Effect of BuShenfang on morphometry of lumbar vertebra in Ovariectomized Rats
作者:
卢建华1; 王维佳1; 陈明涛1; 华江1; 万蕾2; 何剑星3
1.浙江中医药大学附属第一医院,浙江 杭州 310006;
2.浙江省上虞市中医院, 浙江 上虞 312000;
3.中国人民解放军武装警察部队浙江总队杭州医院,浙江 杭州 310053
Author(s):
LU Jian-hua*; WANG Wei-jia; CHEN Ming-tao; et al.*
The first Hospital affiliated to Zhejiang Traditional Chinese Medical University,Hangzhou 310006,Zhejiang China
关键词:
骨质疏松症 左归丸 右归丸 去卵巢大鼠 骨组织形态计量学
Keywords:
Osteoporosis; zuoguowan; youguiwan; Ovariectomized Rats; morphometry
摘要:
目的:研究补肾方(左归丸、右归丸)对去卵巢大鼠腰椎骨形态计量学的影响,为补肾方治疗骨质疏松症提供有力的实验依据。方法:将成年SD大鼠50只,随机分为正常对照组、模型组、阳性对照组、左归丸组、右归丸组,每组10只。造模后第13周开始给药,正常对照组、模型组予蒸馏水灌胃,阳性对照组、左归丸组、右归丸组分别予倍美力水溶液、左归丸煎剂和右归丸煎剂灌胃,给药12周末检测第2腰椎骨形态计量学指标。结果:左归丸、右归丸组与模型组比较,腰椎形态计量学指标明显改善(P<0.05),与阳性对照组比较,差异无统计学意义(P>0.05); 补肾药物左归丸组与右归丸组比较,差异亦无统计学意义(P>0.05)。结论:补肾方能够抑制骨吸收,减少骨量的丢失,对去卵巢大鼠骨质疏松症具有一定的治疗作用。
Abstract:
Objective:To study the Effect of BuShenfang on morphometry of lumbar vertebra in Ovariectomized Rats,also to provid experimental evidence for treating Osteoporosis. Methods:The 50 Ovariectomized SD Rats were randomly divided into normal control group,model group,positive control(OVX)group,Zuoguiwan and Youguiwan group,each group with 10 Rats,after 12 weeks'routine feed,normal control group and model group which were intragastric administration with pure water,positive control group which was intragastric administration with conjugated estrogens water-solution,Zuoguiwan group which was intragastric administration with zuoguiwan decocta,Youguiwan group which was intragastric administration with youguiwan decocta, all the rats were intragastric administration following the schedule 12 weeks,then detect the index of morphometry of Second lumbar vertebra.Results:ComPared with model group,Bushenfang(including zuoguiwan and youguiwan)can obviously improve index of morphometry of lumbar vertebra(P<0.05).while there was no statistical significance when compared with positive control group.Meantime,the effect of zuoguiwan group is similar to the youguiwan group(P>0.05).Conclusion:Bushenfang(including zuoguiwan and youguiwan)can obviously improve index of morphometry of lumbar vertebra,decrease the bone resorption,prevent the loss of bone,strengthen bone Vetrebrae,which can prevent and treat osteoporosis.Meantime,the effect of zuoguiwan group is similar to the youguiwan group.

参考文献/References:

[1] 於文博,张大方,李丽静,等.补肾中药防治骨质疏松症的研究[J].长春中医药大学学报,2008,24(3):262-263.
[2] 王玲,哈孝贤,于顺禄,等.强骨丹对去卵巢大鼠骨组织形态计量学的影响[J].山东中医杂志,2007,26(8):560-562.
[3] 高艳虹,高建军,金慰芳,等.补肾富钙中药对大鼠卵巢辐射损伤所致骨质疏松形态计量学的影响[J].上海交通大学学报,2008,28(5):488-491.
[4] 李全,王立新,卢坚.健骨二仙提取液对去卵巢大鼠骨形态计量学的影响[J].山东医药,2007,47(13):22-23.
[5] 熊昌盛,吴峰,何凤春,等.加味二仙汤颗粒剂防治去势大鼠骨质疏松症的实验研究[J].赣南医学院学报,2008,28(2):815-817.
[6] 于顺禄,白仁骁,郭若霖,等.骨重建过程“四环素活体标记”骨组织形态计量学指标在骨质疏松中的应用[J].中国体视学与图像分析,2003,8(12):119-123.
[7] 陈小砖,李福安,曹亚飞.续断对大鼠去卵巢骨质疏松的骨形态计量学研究[J].中医正骨,2004,16(5):7-9.
[8] 张娟,李娟,黄少慧,等.骨灵片对去卵巢骨质疏松大鼠腰椎形态计量学及生物力学的影响[J].中华老年学杂志,2008,28(9):833-835.

备注/Memo

备注/Memo:
基金项目:浙江省中医药管理局科研项目(NO.2008CA007)
更新日期/Last Update: 2011-05-30