[1]赫军,李冬冬,禹建春,等.综合疗法治疗老年原发性骨质疏松症[J].中医正骨,2017,29(12):56-58.
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综合疗法治疗老年原发性骨质疏松症()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第29卷
期数:
2017年12期
页码:
56-58
栏目:
临床报道
出版日期:
2017-12-20

文章信息/Info

作者:
赫军; 李冬冬; 禹建春; 方苏亭; 孙捷
浙江省台州市博爱医院,浙江 台州 318050
关键词:
骨质疏松;  综合疗法
摘要:
目的:观察综合疗法治疗老年原发性骨质疏松症的临床疗效及安全性。方法:2015年6月至2017年8月,采用健康指导、口服西药及中药治疗老年原发性骨质疏松症患者30例。男2例,女28例。年龄73～97岁,中位数78.5岁。病程4个月至6年,中位数14.5个月。健康指导贯穿于整个治疗过程。碳酸钙D3片,每日1片,晚睡前口服; 阿仑膦酸钠片,每周1片,晨起空腹口服,服后禁食30 min; 自拟中药固本强骨饮,每日1剂,早晚各服用1次; 30 d为1个疗程,连续治疗3个疗程。采用《中药新药临床研究指导原则(试行)》中骨质疏松症的症状分级量化表评定中医证候积分,测定患者的骨密度、血清钙和血清磷含量,采用视觉模拟量表(visual analogue scale,VAS)评定腰背部疼痛情况,采用《中药新药临床研究指导原则(试行)》中骨质疏松症的证候疗效判定标准评价综合疗效。治疗期间观察不良反应发生情况。结果:治疗3个疗程后,30例患者的中医证候积分、血清钙含量、血清磷含量及腰背部疼痛VAS评分均较治疗前下降[(12.09±4.89)分,(8.36±3.78)分,t=3.017,P=0.002;(26.07±1.56)mg·dL-1,(14.60±2.35)mg·dL-1,t=3.012,P=0.002;(25.06±1.01)mg·dL-1,(13.31±1.02)mg·dL-1,t=3.002,P=0.002;(8.86±1.14)分,(3.81±1.02)分,t=2.032,P=0.002],骨密度较治疗前增高[(0.69±0.15)g·cm-2,(0.81±0.15)g·cm-2,t=2.013,P=0.001]; 按照上述证候疗效标准评价综合疗效,临床痊愈1例、显效10例、有效16例、无效3例。治疗期间出现便溏2例、食欲下降2例、恶心及干呕1例,均未进行特殊处理,自然缓解。结论:综合疗法治疗老年原发性骨质疏松症,可以调节血清钙和血清磷含量,提高骨密度,减轻腰背部疼痛,具有综合疗效好、安全性高的优点。

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更新日期/Last Update: 2018-05-02