[1]刘康,周航,惠明大,等.酪蛋白激酶-2相互作用蛋白-1介导的自噬通路与骨质疏松症的关系探讨[J].中医正骨,2022,34(06):57-61.
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酪蛋白激酶-2相互作用蛋白-1介导的自噬通路与骨质疏松症的关系探讨()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期数:
2022年06期
页码:
57-61
栏目:
学术探讨
出版日期:
2022-06-20

文章信息/Info

作者:
刘康1周航2惠明大3黄海2何才剑2房谋昊2陈天鹏2史晓林1
(1.浙江中医药大学附属第二医院,浙江 杭州 310005; 2.浙江中医药大学第二临床医学院,浙江 杭州 310053; 3.诸暨市中心医院,浙江 诸暨 311899)
关键词:
骨质疏松 自吞噬 酪蛋白激酶-2相互作用蛋白-1
摘要:
骨质疏松症被认为是一种典型的增龄性疾病,其原因是骨重建受损,并伴有成骨细胞和破骨细胞数量和活性的失衡。自噬作为一种细胞生存途径,在成骨细胞或破骨细胞退变过程中起着重要作用。酪蛋白激酶-2相互作用蛋白-1(casein kinase 2 interacting protein-1,CKIP-1)可以通过磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路参与骨细胞自噬,被认为与骨质疏松症的发生具有重要的关系。本文阐述了自噬的概念及发生机制,介绍了自噬与骨质疏松症的关系,重点探讨了CKIP-1介导的自噬通路与骨质疏松症的关系。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(81873129) 通讯作者:史晓林 E-mail:xlshi-2002@163.com
更新日期/Last Update: 1900-01-01