参考文献/References:
[1] MOTYL K J,GUNTUR A R,CARVALHO A L,et al.Energy metabolism of bone[J].Toxicol Pathol,2017,45(7):887-893.
[2] BOSC D G,GRAHAM K C,SAULNIER R B,et al.Identification and characterization of CKIP-1,a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2[J].J Biol Chem,2000,275(19):14295-14306.
[3] OZDAMAR B,BOSE R,BARRIOS-RODILES M,et al.Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity[J].Science,2005,307(5715):1603-1609.
[4] PENG X,WU X,ZHANG J,et al.The role of CKIP-1 in osteoporosis development and treatment[J].Bone Joint Res,2018,7(2):173-178.
[5] LU K,YIN X,WENG T,et al.Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1[J].Nat Cell Biol,2008,10(8):994-1002.
[6] LIU J,LU C,WU X,et al.Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis[J].Sci Rep,2017,7:41295.
[7] HUANG X,LIANG J,GAO Y,et al.Ckip-1 regulates C3H10T1/2 mesenchymal cell proliferation and osteogenic differentiation via Lrp5[J].Exp Ther Med,2021,21(4):342.
[8] 梁建飞.下调Ckip-1通过骨形成相关信号通路促进MSCs增殖及成骨分化的作用研究[D].西安:第四军医大学,2017.
[9] GREENHILL C.Bone:autophagy regulates bone growth in mice[J].Nat Rev Endocrinol,2016,12(1):4.
[10] BO T,YAN F,GUO J,et al.Characterization of a relatively malignant form of osteopetrosis caused by a novel mutation in the PLEKHM1 gene[J].J Bone Miner Res,2016,31(11):1979-1987.
[11] WU Q,ZHONG Z M,PAN Y,et al.Advanced oxidation protein products as a novel marker of oxidative stress in post-menopausal osteoporosis[J].Med Sci Monit,2015,21:2428-2432.
[12] 杨依然.CKIP-1介导mTOR通路对绝经后骨质疏松症致病机理及强骨饮对其干预的研究[D].杭州:浙江中医药大学,2021.
[13] PARZYCH K R,KLIONSKY D J.An overview of auto-phagy:morphology,mechanism,and regulation[J].Antioxid Redox Signal,2014,20(3):460-473.
[14] CUERVO A M,WONG E.Chaperone-mediated auto-phagy:roles in disease and aging[J].Cell Res,2014,24(1):92-104.
[15] MIZUSHIMA N,KOMATSU M.Autophagy:renovation of cells and tissues[J].Cell,2011,147(4):728-741.
[16] BEGUN J,XAVIER R J.Autophagy at the crossroads of metabolism and cellular defense[J].Curr Opin Gastroenterol,2013,29(6):588-596.
[17] SARPARANTA J,GARCÍA-MACIA M,SINGH R.Autophagy and mitochondria in obesity and type 2 diabetes[J].Curr Diabetes Rev,2017,13(4):352-369.
[18] REVUELTA M,MATHEU A.Autophagy in stem cell aging[J].Aging Cell,2017,16(5):912-915.
[19] PIERREFITE-CARLE V,SANTUCCI-DARMANIN S,BREUIL V,et al.Autophagy in bone:self-eating to stay in balance[J].Ageing Res Rev,2015,24(Pt B):206-217.
[20] NIXON R A.The role of autophagy in neurodegenerative disease[J].Nat Med,2013,19(8):983-997.
[21] CHAGIN A S.Effectors of mTOR-autophagy pathway:targeting cancer,affecting the skeleton[J].Curr Opin Pharmacol,2016,28:1-7.
[22] ENGELMAN J A,LUO J,CANTLEY L C.The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism[J].Nat Rev Genet,2006,7(8):606-619.
[23] BACKER J M.The intricate regulation and complex functions of the Class Ⅲ phosphoinositide 3-kinase Vps34[J].Biochem J,2016,473(15):2251-2271.
[24] DE SANTIS M C,GULLUNI F,CAMPA C C,et al.Targeting PI3K signaling in cancer:challenges and advances[J].Biochim Biophys Acta Rev Cancer,2019,1871(2):361-366.
[25] ALESSI D R,JAMES S R,DOWNES C P,et al.Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha[J].Curr Biol,1997,7(4):261-269.
[26] HUANG J,MANNING B D.A complex interplay between Akt,TSC2 and the two mTOR complexes[J].Biochem Soc Trans,2009,37(Pt 1):217-222.
[27] KIM J,KUNDU M,VIOLLET B,et al.AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1[J].Nat Cell Biol,2011,13(2):132-141.
[28] ZACHARI M,GANLEY I G.The mammalian ULK1 complex and autophagy initiation[J].Essays Biochem,2017,61(6):585-596.
[29] CHEN Y,HE J,TIAN M,et al.UNC51-like kinase 1,autophagic regulator and cancer therapeutic target[J].Cell Prolif,2014,47(6):494-505.
[30] XI G,ROSEN C J,CLEMMONS D R.IGF-I and IGFBP-2 stimulate AMPK activation and autophagy,which are required for osteoblast differentiation[J].Endocrinology,2016,157(1):268-281.
[31] LIU F,FANG F,YUAN H,et al.Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation[J].J Bone Miner Res,2013,28(11):2414-2430.
[32] NOLLET M,SANTUCCI-DARMANIN S,BREUIL V,et al.Autophagy in osteoblasts is involved in mineralization and bone homeostasis[J].Autophagy,2014,10(11):1965-1977.
[33] VUPPALAPATI K K,BOUDERLIQUE T,NEWTON P T,et al.Targeted deletion of autophagy genes Atg5 or Atg7 in the chondrocytes promotes caspase-dependent cell death and leads to mild growth retardation[J].J Bone Miner Res,2015,30(12):2249-2261.
[34] SHIN N Y,CHOI H,NEFF L,et al.Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts[J].J Cell Biol,2014,207(1):73-89.
[35] DESELM C J,MILLER B C,ZOU W,et al.Autophagy proteins regulate the secretory component of osteoclastic bone resorption[J].Dev Cell,2011,21(5):966-974.
[36] LIN N Y,CHEN C W,KAGWIRIA R,et al.Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss[J].Ann Rheum Dis,2016,75(6):1203-1210.
[37] 米健国,乔荣勤,刘少津.补肾健脾活血方干预骨质疏松模型大鼠骨代谢、氧化应激及自噬的变化[J].中国组织工程研究,2022,26(26):4147-4152.
[38] 招文华,任辉,沈耿杨,等.mTORC1抑制自噬调控Wnt/β-catenin信号通路在激素环境下对MC3T3-E1成骨分化的影响[J].中国骨质疏松杂志,2022,28(1):16-20.
[39] 李希宁,董颖,赵宇,等.雷帕霉素通过抑制mTOR通路激活自噬缓解氟骨症大鼠早期的骨质疏松[J].中华劳动卫生职业病杂志,2021,39(5):321-327.
[40] BOSC D G,GRAHAM K C,SAULNIER R B,et al.Identification and characterization of CKIP-1,a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2[J].J Biol Chem,2000,275(19):14295-14306.
[41] OZDAMAR B,BOSE R,BARRIOS-RODILES M,et al.Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity[J].Science,2005,307(5715):1603-1609.
[42] FU L,ZHANG L.Physiological functions of CKIP-1:from molecular mechanisms to therapy implications[J].Ageing Res Rev,2019,53:100908.
[43] ZHANG G,GUO B,WU H,et al.A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy[J].Nat Med,2012,18(2):307-314.
[44] LIU J,LIANG C,GUO B,et al.Increased PLEKHO1 within osteoblasts suppresses smad-dependent BMP signaling to inhibit bone formation during aging[J].Aging Cell,2017,16(2):360-376.
[45] LIU J,LU C,WU X,et al.Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis[J].Sci Rep,2017,7:41295.
[46] HUANG X,LIANG J,GAO Y,et al.Ckip-1 regulates C3H10T1/2 mesenchymal cell proliferation and osteogenic differentiation via Lrp5[J].Exp Ther Med,2021,21(4):342.
[47] TOKUDA E,FUJITA N,OH-HARA T,et al.Casein kinase 2-interacting protein-1,a novel Akt pleckstrin homology domain-interacting protein,down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo[J].Cancer Res,2007,67(20):9666-9676.
[48] YUAN Y,SUN J,ZHOU H,et al.The effect of QiangGuYin on osteoporosis through the AKT/mTOR/autophagy signaling pathway mediated by CKIP-1[J].Aging(Albany NY),2022,14(2):892-906.
中医正骨2022年6月第34卷第6期 J Trad Chin Orthop Trauma,2022,Vol.34,No.6(总461)
(总462)中医正骨2022年6月第34卷第6期 J Trad Chin Orthop Trauma,2022,Vol.34,No.6
[49] ZHANG L,WANG Y,XIAO F,et al.CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation[J].Cell Res,2014,24(6):742-761.
[50] LUO D,REN H,LI T,et al.Rapamycin reduces severity of senile osteoporosis by activating osteocyte autophagy[J].Osteoporos Int,2016,27(3):1093-1101.
[51] YIN Z Y,YIN J,HUO Y F,et al.Rapamycin facilitates fracture healing through inducing cell autophagy and suppressing cell apoptosis in bone tissues[J].Eur Rev Med Pharmacol Sci,2017,21(21):4989-4998.
[52] SHEN G,REN H,SHANG Q,et al.Autophagy as a target for glucocorticoid-induced osteoporosis therapy[J].Cell Mol Life Sci,2018,75(15):2683-2693.
[53] HAN Y,ZHANG L,XING Y,et al.Autophagy relieves the function inhibition and apoptosis-promoting effects on osteoblast induced by glucocorticoid[J].Int J Mol Med,2018,41(2):800-808.
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