参考文献/References:
[1] NAVARRO-COMPÁN V,SEPRIANO A,CAPELUSNIK D,et al.Axial spondyloarthritis[J].The Lancet,2025,405(10473):159-172.
[2] 王睿尧,康武林,秦鹏俊,等.中西医治疗强直性脊柱炎的研究进展[J].世界中医药,2022,17(21):3107-3111.
[3] VAN DER HEIJDE D,BARALIAKOS X,SIEPER J,et al.Efficacy and safety of upadacitinib for active ankylosing spondylitis refractory to biological therapy:a double-blind,randomised,placebo-controlled phase 3 trial[J].Ann Rheum Dis,2022,81(11):1515-1523.
[4] 闫婷婷,李军霞.肠道菌群与强直性脊柱炎的关系[J].现代免疫学,2021,41(1):84-87.
[5] DUREGON E,POMATTO-WATSON L C D D,BERNIER M,et al.Intermittent fasting:from calories to time restriction[J].Geroscience,2021,43(3):1083-1092.
[6] VERNIERI C,FUCA G,LIGORIO F,et al.Fasting-mim-icking diet is safe and reshapes metabolism and antitumor immunity in patients with cancer[J].Cancer Discov,2022,12(1):90-107.
[7] BARATI M,GHAHREMANI A,NAMDAR AHMADABAD H.Intermittent fasting:a promising dietary intervention for autoimmune diseases[J].Autoimmun Rev,2023,22(10):103408.
[8] BROGI S,TABANELLI R,PUCA S,et al.Intermittent fasting:myths,fakes and truth on this dietary regimen approach[J].Foods,2024,13(13):4123.
[9] 张熙冰,牛玲,刘方,等.热量限制与间歇性禁食对炎症及代谢疾病的影响[J].昆明医科大学学报,2024,45(12):1-9.
[10] 王振东,杨娟娟,李浩林,等.强直性脊柱炎的发病机制及中药干预研究进展[J].中国实验方剂学杂志,2024,30(22):289-298.
[11] WATAD A,CUTHBERT R J,AMITAL H,et al.Enthesitis:much more than focal insertion point inflammation[J].Curr Rheumatol Rep,2018,20(7):41.
[12] 陈悦宁,刘宏潇.聚焦固有和适应性免疫在强直性脊柱炎机制研究中的紧迫感与切入点[J].中国免疫学杂志,2025,41(6):1497-1503.
[13] 杨德仪,林靖涵,王涛,等.中药调控肠道菌群代谢产物干预疾病研究进展[J].生物工程学报,2025,41(6):2236-2255.
[14] DE VOS W M,TILG H,VAN HUL M,et al.Gut microbiome and health:mechanistic insights[J].Gut,2022,71(5):1020-1032.
[15] LIU G,HAO Y,YANG Q,et al.The association of fecal microbiota in ankylosing spondylitis cases with c-reactive protein and erythrocyte sedimentation rate[J].Mediators Inflamm,2020,2020:8884324.
[16] 任彩英,郑洁,赵莉平.基于肠-关节轴理论探讨针灸治疗膝关节骨性关节炎[J].针灸临床杂志,2024,40(12):1-5.
[17] ZAISS M M,JOYCE WU H J,MAURO D,et al.The gut-joint axis in rheumatoid arthritis[J].Nat Rev Rheumatol,2021,17(4):224-237.
[18] 谭城举,金红波,黎小东,等.强直性脊柱炎的病因、发病机制及预防研究进展[J].华南预防医学,2023,49(6):672-675.
[19] 彭元直,丁国永.维生素D对强直性脊柱炎作用机制及流行病学研究现状[J].中华风湿病学杂志,2024,28(12):1-6.
[20] 梁仙志,廖旻晶,王宏波,等.肠道微生物群与部分人类疾病的研究进展[J].基因组学与应用生物学,2020,39(12):5874-5880.
[21] 黄媛媛,陈华国,谢文,等.多糖与肠道菌群相互作用及其构效关系研究进展[J].微生物学通报,2022,49(6):2325-2346.
[22] ZHAO T,WEI Y,ZHU Y,et al.Gut microbiota and rheumatoid arthritis:from pathogenesis to novel therapeutic opportunities[J].Front Immunol,2022,13:1007165.
[23] KOH A,DE VADDER F,KOVATCHEVA-DATCHARY P,et al.From dietary fiber to host physiology:short-chain fatty acids as key bacterial metabolites[J].Cell,2016,165(6):1332-1345.
[24] WANG X,CAI Z,WANG Q,et al.Bacteroides methylmalonyl-CoA mutase produces propionate that promotes intestinal goblet cell differentiation and homeostasis[J].Cell Host Microbe,2024,32(1):63-78.
[25] FRISCIC J,DÜRHOLZ K,CHEN X,et al.Dietary derived propionate regulates pathogenic fibroblast function and ameliorates experimental arthritis and inflammatory tissue priming[J].Nutrients,2021,13(5):1643.
[26] CHUN E,LAVOIE S,FONSECA-PEREIRA D,et al.Meta-bolite-sensing receptor Ffar2 regulates colonic group 3 innate lymphoid cells and gut immunity[J].Immunity,2019,51(5):871-884.
[27] LIU B Y,YE B Q,ZHU X X,et al.An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution[J].Nat Commun,2020,11(1):4076.
[28] MARTIN-GALLAUSIEUX C,BÉGUET-CRESTEL F,MARIN-ELLI L,et al.Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells[J].Sci Rep,2018,8(1):9742.
[29] SUN Q,JI Y C,WANG Z L,et al.Sodium butyrate alleviates intestinal inflammation in mice with necrotizing enterocolitis[J].Mediators Inflamm,2021,2021:6259381.
[30] SCHROEDER B O,BIRCHENOUGH G M H,STAHLMAN M,et al.Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration[J].Cell Host Microbe,2018,23(1):27-40.
[31] HU C,XU B,WANG X,et al.Gut microbiota-derived short-chain fatty acids regulate group 3 innate lymphoid cells in HCC[J].Hepatology,2023,77(1):48-64.
[32] 彭丹,何秋水,张晶.肠道菌群代谢产物对免疫细胞的作用[J].现代免疫学,2022,42(4):317-322.
[33] BRAUN J.Fast,present and future of the concept of spondyloarthritis[J].Curr Rheumatol Rep,2025,27(1):15.
[34] 杨娟娟,李浩林,王振东,等.强直性脊柱炎的骨免疫学机制及中医药治疗的研究进展[J].中药新药与临床药理,2024,35(8):1264-1271.
[35] RAZA I,CLARKE A J.B cell metabolism and autophagy in autoimmunity[J].Front Immunol,2021,12:681105.
[36] PETTA I,FRAUSSEN J,SOMERS V,et al.Interrelation of diet,gut microbiome,and autoantibody production[J].Front Immunol,2018,9:439.
[37] ZHAI L J,BELL A,LADOMERSKY E,et al.Immunosuppressive IDO in cancer:mechanisms of action,animal models,and targeting strategies[J].Front Immunol,2020,11:1185.
[38] 张淑红,吴夏青,王红娟,等.天然产物修复肠道屏障缓解溃疡性结肠炎的研究进展[J].中国病理生理杂志,2025,41(5):1014-1023.
[39] POTHOVEN K L,SCHLEIMER R P.The barrier hypothesis and oncostatin M:restoration of epithelial barrier function as a novel therapeutic strategy for the treatment of type 2 inflammatory disease[J].Tissue Barriers,2017,5(3):e1341367.
[40] 杨娟娟,陈平,王海东,等.基于IL-17A/Wnt/β-catenin信号通路探讨五劳七损方对强直性脊柱炎小鼠病理性新骨形成的影响[J].中成药,2026,48(3):806-815.
[41] 邢立来,刘君,孙尧尧,等.中药调控肠道菌群治疗类风湿关节炎机制研究进展[J].国际中医中药杂志,2025,47(2):281-285.
[42] 雷张妮,厉英超.炎症性肠病伴发中轴型脊柱关节炎的研究进展[J].中华消化杂志,2024,44(11):778-782.
[43] KOHL K D,AMAYA J,PASSEMENT C A,et al.Unique and shared responses of the gut microbiota to prolonged fasting:a comparative study across five classes of vertebrate hosts[J].FEMS Microbiol Ecol,2014,90(3):883-894.
[44] 孙桂丽,邓志杰,黄丽婵,等.“5+2”间歇性断食模式对体重超标患者的临床效果研究[J].医学综述,2021,27(3):598-603.
[45] 陈语涵,郑萍.间歇性禁食对动物肠道健康的影响研究进展[J].动物营养学报,2024,36(4):2143-2154.
[46] HU X W,XIA K,DAI M H,et al.Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism[J].NPJ Biofilms Microbiomes,2023,9(1):19.
[47] 李亦汉,王琳琳,赵建新,等.两歧双歧杆菌CCFM1167通过提升肠道中乙酸水平以抑制炎症从而缓解便秘[J].食品与发酵工业,2023,49(6):35-41.
[48] 卫钰成,杨敏敏,施琳,等.滇黄精水提物联合间歇性禁食通过调节肠道菌群改善高脂饮食诱导的小鼠肥胖及肝损伤[J].食品与发酵工业,2022,48(13):91-102.
[49] 汪涛,王顺谱,闵友江,等.肠道菌群与类风湿关节炎的因果关系:GWAS数据欧洲群体资料分析[J].中国组织工程研究,2025,29(35):7663-7668.
[50] CATTERSON J H,KHERICHA M,DYSON M C,et al.Short-term,intermittent fasting induces long-lasting gut health and TOR-independent lifespan extension[J].Current Biology,2018,28(11):1714-1724.
[51] 唐乙萍,董曾荣,青玉凤.强直性脊柱炎发病机制中的细胞自噬[J].中华临床免疫和变态反应杂志,2020,14(4):376-380.
[52] ZHANG A,WANG J,ZHAO Y,et al.Intermittent fasting,fatty acid metabolism reprogramming,and neuroimmuno microenvironment:mechanisms and application prospects[J].Front Nutr,2024,11:1485632.
[53] FOERSTER E G,MUKHERJEE T,CABRAL-FERNANDES L,et al.How autophagy controls the intestinal epithelial barrier[J].Autophagy,2022,18(1):86-103.
[54] WU Y,HANG Z,LEI T,et al.Intestinal flora affect Alzheimer's disease by regulating endogenous hormones[J].Neurochem Res,2022,47(12):3565-3582.
[55] 崔月娜,陈晓瑜,梁美婷,等.节食与限时进食小鼠代谢指标及肠道菌群分布差异[J].中国组织工程研究,2025,29(30):6449-6456.
[56] RUIZ A,CERDÓ T,JUREGUI R,et al.One-year calorie restriction impacts gut microbial composition but not its metabolic performance in obese adolescents[J].Environ Microbiol,2017,19(4):1536-1551.
[57] FITZGERALD K C,TYRY T,SALTER A,et al.A survey of dietary characteristics in a large population of people with multiple sclerosis[J].Mult Scler Relat Disord,2018,22:12-18.
[58] LIU T,ZHANG L,JOO D,et al.NF-kappaB signaling in inflammation[J].Signal Transduct Target Ther,2017,2:17023.
[59] 任杰,杨凯.间歇性禁食通过NF-κB通路减轻牙周炎小鼠牙槽骨吸收[J].临床口腔医学杂志,2025,41(4):201-204.
[60] MULAS A,CIENFUEGOS S,EZPELETA M,et al.Effect of intermittent fasting on circulating inflammatory markers in obesity:a review of human trials[J].Front Nutr,2023,10:1146924.
[61] RAZEGHI JAHROMI S,GHAEMI A,ALIZADEH A,et al.Effects of intermittent fasting on experimental autoimmune encephalomyelitis in C57BL/6 mice[J].Iran J Allergy Asthma Immunol,2016,15(3):212-219.
[62] MAYOR E.Neurotrophic effects of intermittent fasting,calorie restriction and exercise:a review and annotated bibliography[J].Front Aging,2023,4:1161814.
[63] ZHAO Y,JIA M,CHEN W,et al.The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function[J].Free Ra-dic Biol Med,2022,182:206-218.
[64] 孙铭雨,辛婧,程爱斌,等.间歇性禁食与代谢相关脂肪性肝病的研究进展[J].安徽医科大学学报,2024,59(4):742-746.
[65] ULGHERAIT M,MIDOUN ADIL M,PARK S,et al.Circadian autophagy drives iTRF-mediated longevity[J].Nature,2021,598(7880):353-358.
[66] 邓亚胜,林江,兰太进,等.基于子午流注的间歇性禁食干预策略[J].中医杂志,2025,66(20):2109-2114.
[67] LI Z,HEBER D.Intermittent fasting[J].JAMA,2021,326(13):1338.
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