参考文献/References:
[1] GBD 2019 Diseases and Injuries Collaborators.Global burden of 369 diseases and injuries in 204 countries and territories,1990-2019:a systematic analysis for the global burden of disease study 2019[J].Lancet,2020,396(10258):1204-1222.
[2] FRANCISCO V,PINO J,GONZÁLEZ-GAYMÁ,et al.A new immunometabolic perspective of intervertebral disc degeneration[J].Nat Rev Rheumatol,2022,18(1):47-60.
[3] BAO X,WANG Z,JIA Q,et al.HIF-1α-Mediated miR-623 regulates apoptosis and inflammatory responses of nucleus pulposus induced by oxidative stress via targeting TXNIP[J/OL].Oxid Med Cell Longev,2021,2021:6389568[2023-01-20].https://pubmed.ncbi.nlm.nih.gov/34394829/.
[4] MCDONNELL E E,BUCKLEY C T.Consolidating and re-evaluating the human disc nutrient microenvironment[J].J Spine,2022,5(1):e1192.
[5] XIAN D,GUO M,XU J,et al.Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses[J].Redox Rep,2021,26(1):134-146.
[6] CHENG Y,YANG H,HAI Y,et al.Scientific literature landscape analysis of researches on oxidative stress in intervertebral disc degeneration in web of science[J].Front Mol Biosci,2022,9:989627.
[7] CHE H,LI J,LI Y,et al.p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle[J].Elife,2020,9:e52570.
[8] LU Y,ZHOU L,HE S,et al.Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway[J].Mol Cell Probes,2020,51:101559.
[9] ZEROVNIK E,VENTURA S,KOPITAR-JERALA N.Special issue:“inflammation,oxidative stress and protein aggregation; any links?”[J].Cells,2020,9(11):2461.
[10] WANG L,HE T,LIU J,et al.Revealing the immune infiltration landscape and identifying diagnostic biomarkers for lumbar disc herniation[J].Front Immunol,2021,12:666355.
[11] PARK M S,LEE H M,HAHN S B,et al.The association of the activation-inducible tumor necrosis factor receptor and ligand with lumbar disc herniation[J].Yonsei Med J,2007,48(5):839-846.
[12] XIA C,ZENG Z,FANG B,et al.Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects[J].Free Radic Biol Med,2019,143:1-15.
[13] FENG C,YANG M,LAN M,et al.ROS:crucial intermediators in the pathogenesis of intervertebral disc degenera-tion[J/OL].Oxid Med Cell Longev,2017,2017:5601593[2023-01-20].https://pubmed.ncbi.nlm.nih.gov/28392887/.
[14] SUZUKI S,FUJITA N,HOSOGANE N,et al.Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration[J].Arthritis Res Ther,2015,17:316.
[15] QUAN M,HONG M W,KO M S,et al.Relationships between disc degeneration and autophagy expression in human nucleus pulposus[J].Orthop Surg,2020,12(1):312-320.
[16] JIANG L,ZHANG X,ZHENG X,et al.Apoptosis,senescence,and autophagy in rat nucleus pulposus cells:implications for diabetic intervertebral disc degeneration[J].J Orthop Res,2013,31(5):692-702.
[17] LIU Z,HUANG Y,JIAO Y,et al.Polystyrene nanoplastic induces ROS production and affects the MAPK-HIF-1/NFkB-mediated antioxidant system in Daphnia pulex[J/OL].Aquat Toxicol,2020,220:105420[2023-01-20].https://pubmed.ncbi.nlm.nih.gov/31986404/.
[18] TANG Z,HU B,ZANG F,et al.Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration[J].Cell Death Dis,2019,10(7):510.
[19] HU S,ZHANG C,QIAN T,et al.Promoting Nrf2/Sirt3-dependent mitophagy suppresses apoptosis in nucleus pulposus cells and protects against intervertebral disc degeneration[J/OL].Oxid Med Cell Longev,2021,2021:6694964[2023-01-20].https://pubmed.ncbi.nlm.nih.gov/34211633/.
[20] LIANG D,HONG D,TANG F,et al.Upregulated lnc HRK 2:1 prompts nucleus pulposus cell senescence in intervertebral disc degeneration[J].Mol Med Rep,2020,22(6):5251-5261.
[21] NOVAIS E J,DIEKMAN B O,SHAPIRO I M,et al.p16Ink4adeletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence[J].Matrix Biol,2019,82:54-70.
[22] FENG C,LIU H,YANG M,et al.Disc cell senescence in intervertebral disc degeneration:causes and molecular pathways[J].Cell Cycle,2016,15(13):1674-1684.
[23] CHE H,LI J,LI Y,et al.p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle[J].Elife,2020,9:e52570.
[24] PATIL P,FALABELLA M,SAEED A,et al.Oxidative stress-induced senescence markedly increases disc cell bioenergetics[J].Mech Ageing Dev,2019,180:97-106.
[25] 王雁秋.Nrf2抑制氧化应激所致髓核细胞凋亡和衰老的实验研究[D].重庆:陆军军医大学,2020.
[26] CHEN J W,NI B B,LI B,et al.The responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells:implications for disc degeneration[J].Cell Physiol Biochem,2014,34(4):1175-1189.
[27] 尹思,杜恒,赵为公,等.阻断双侧终板营养途径构建山羊椎间盘退变模型[J].临床骨科杂志,2020,23(1):145-150.
[28] YURUBE T,BUCHSER W J,MOON H J,et al.Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells:an in vitro experimental study[J].Eur Spine J,2019,28(5):993-1004.
[29] ZUO R,WANG Y,LI J,et al.Rapamycin induced autophagy inhibits inflammation-mediated endplate degeneration by enhancing Nrf2/Keap1 signaling of cartilage endplate stem cells[J].Stem Cells,2019,37(6):828-840.
[30] KANG L,LIU S,LI J,et al.Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defensesv[J].Life Sci,2020,243:117244.
[31] WANG H,JIANG Z,PANG Z,et al.Acacetin alleviates inflammation and matrix degradation in nucleus pulposus cells and ameliorates intervertebral disc degeneration in vivo[J].Drug Des Devel Ther,2020,14:4801-4813.
[32] YU C,LI D,WANG C,et al.Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell[J].Bioact Mater,2021,6(10):3568-3579.
[33] 蔡同川,张亮.白藜芦醇与椎间盘退变性疾病[J].国际骨科学杂志,2021,42(1):22-25.
[34] CHEN D,XIA D,PAN Z,et al.Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo[J].Cell Death Dis,2016,7(10):e2441.
[35] KRUPKOVA O,HANDA J,HLAVNA M,et al.The natural polyphenol epigallocatechin gallate protects intervertebral disc cells from oxidative stressv[J/OL].Oxid Med Cell Longev,2016,2016:7031397[2023-01-20].https://pubmed.ncbi.nlm.nih.gov/27119009/.
[36] LIU Q,WANG X,HUA Y,et al.Estrogen deficiency exacerbates intervertebral disc degeneration induced by spinal instability in rats[J].Spine(Phila Pa 1976),2019,44(9):E510-519.
[37] XIA C,ZENG Z,FANG B,et al.Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects[J].Free Radic Biol Med,2019,143:1-15.
[38] HU Y,TAO R,WANG L,et al.Exosomes derived from bone mesenchymal stem cells alleviate compression-induced nucleus pulposus cell apoptosis by inhibiting oxidative stress[J/OL].Oxid Med Cell Longev,2021,2021:2310025[2023-01-20].https://pubmed.ncbi.nlm.nih.gov/34733401/.