[1]应俊,张元斌,罗程,等.核转录因子-κB在骨关节炎炎症反应中的作用[J].中医正骨,2015,27(07):40-43.
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核转录因子-κB在骨关节炎炎症反应中的作用()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第27卷
期数:
2015年07期
页码:
40-43
栏目:
膝骨关节炎
出版日期:
2015-07-31

文章信息/Info

作者:
应俊1张元斌1罗程1金红婷1肖鲁伟1童培建2
1.浙江中医药大学,浙江 杭州 310053;
2.浙江省中医院,浙江 杭州 310006
关键词:
NF-κB 骨关节炎 综述
摘要:
核转录因子κB(nuclear factor-kappa B,NF-κB)是机体中极为重要的转录因子,参与机体的炎症与免疫反应、凋亡与抗凋亡以及细胞的周期调控与发育等诸多功能的调节。NF-κB信号通路在关节软骨的发育及骨关节炎的发生、发展中扮演着重要角色。本文对NF-κB及其信号通路进行了简单的介绍,并从NF-κB信号通路、NF-κB核移位在骨关节炎炎症反应中的作用以及基于NF-kB治疗骨关节炎的药物研究3个方面对NF-κB在骨关节炎炎症反应中的作用进行了综述。

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备注/Memo

备注/Memo:
2015-01-28收稿 2015-03-02修回
基金项目:国家自然科学基金项目(81373669); 浙江省科技计划项目(2012C13017-2); 浙江省省部共建项目(201487674)
通讯作者:童培建 E-mail:tongpeijian@163.com
更新日期/Last Update: 2015-07-30