[1]高宁阳,丁立,庞坚,等.miRNAs与骨关节炎关系的研究进展[J].中医正骨,2015,27(12):74-77.
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miRNAs与骨关节炎关系的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第27卷
期数:
2015年12期
页码:
74-77
栏目:
综述
出版日期:
2015-12-30

文章信息/Info

作者:
高宁阳丁立庞坚陈博曹月龙詹红生石印玉
上海中医药大学附属曙光医院,上海 201203
关键词:
微RNAs 骨关节炎 综述
摘要:
骨关节炎以软骨的进行性破坏为病理特征,是导致老年人慢性肌肉骨骼疼痛和活动障碍的最主要原因。随着对软骨代谢分子机制不断地深入了解,现认为miRNAs具有调节软骨发育及维持软骨代谢平衡的作用,是治疗骨关节炎的新靶点。同时,研究发现miRNAs可通过对炎性因子及神经细胞中致痛因子的调控,对骨关节炎所致疼痛产生调节作用。本文从miRNAs的基本生物学特性与功能,以及miRNAs与关节软骨、滑膜炎症和疼痛的关系等方面的研究进展对miRNAs与骨关节炎的关系进行了综述。

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备注/Memo

备注/Memo:
2015-07-13收稿 2015-11-11修回
基金项目:国家自然科学基金资助项目(81173277、81373665); 国家自然科学基金青年科学基金资助项目(81302988); 国家科技重大专项项目(2015ZX09101021); 上海市中医药事业发展三年行动计划项目(ZYSNXD-CC-ZDYJ047); 上海市中医药事业发展三年行动计划项目(ZY3-JSFC-2-1035); 上海市科学技术委员会科研计划项目(13401902502); 上海科学技术委员会资助项目(13411850
更新日期/Last Update: 2015-12-30