[1]王用玉,陈博,许坤,等.口服补肾活血中药治疗老年桡骨远端骨折临床疗效的Meta分析[J].中医正骨,2021,33(09):25-31.
　WANG Yongyu,CHEN Bo,XU Kun,et al.Clinical efficacy of oral application of Bushen Huoxue(补肾活血)traditional Chinese drugs for treatment of distal radius fractures in the aged:a meta-analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(09):25-31.
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口服补肾活血中药治疗老年桡骨远端骨折临床疗效的Meta分析()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第33卷
期数:
2021年09期
页码:
25-31
栏目:
文献研究
出版日期:
2021-09-20

文章信息/Info

Title:
Clinical efficacy of oral application of Bushen Huoxue(补肾活血)traditional Chinese drugs for treatment of distal radius fractures in the aged:a meta-analysis
作者:
王用玉1; 2; 陈博1; 2; 许坤1; 2; 田飚1; 2; 张洁帆1; 2; 郭海玲1; 2; 赵咏芳1; 2; 詹红生1; 2; 陈元川1; 2; 庞坚1; 2
(1.上海中医药大学附属曙光医院,上海 201203; 2.上海市中医药研究院骨伤科研究所,上海 201203)
Author(s):
WANG Yongyu1; 2; CHEN Bo1; 2; XU Kun1; 2; TIAN Biao1; 2; ZHANG Jiefan1; 2; GUO Hailing1; 2; ZHAO Yongfang1; 2; ZHAN Hongsheng1; 2; CHEN Yuanchuan1; 2; PANG Jian1; 2
1.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China2.The Institute of Traumatology and Orthopedics Affiliated to Shanghai Academy of Traditional Chinese Medicine,Shanghai 201203,China
关键词:
桡骨骨折;  腕关节;  老年人;  补肾活血中药;  Meta分析;  系统评价
Keywords:
radius fractures;  carpal joints;  aged;  reinforcing kidney and activating blood(TCD);  meta analysis;  systematic review
摘要:
目的:系统评价口服补肾活血中药治疗老年桡骨远端骨折的临床疗效。方法:应用计算机检索中国知网、万方数据库、维普网、中国生物医学文献数据库、PubMed、Cochrane Library、Web of science、EBSCO、EMbase建库至2020年1月收录的有关闭合复位夹板固定或切开复位内固定术联合口服补肾活血中药(试验组)和单纯闭合复位夹板固定或切开复位内固定术(对照组)治疗老年桡骨远端骨折的随机对照临床研究文献。由2名研究者按照纳入、排除标准独立进行文献筛选和数据提取,采用Cochrane偏倚风险评估工具对纳入研究文献的质量进行评价,采用RevMan5.3软件进行Meta分析。结果:共检索出1569篇文献,最终纳入12篇文献,共涉及1039例老年桡骨远端骨折患者,其中对照组519例、试验组520例。Meta分析结果显示,试验组骨折愈合时间短于对照组[I2=0%,P=1.000,MD=-0.77,95%CI(-0.94,-0.59)],Gartland-Werley腕关节功能评分低于对照组[I2=26%,P=0.190,MD=-2.21,95%CI(-2.43,-1.98)],腕关节患者自评量表评分低于对照组[I2=0%,P=1.000,MD=-3.97,95%CI(-4.85,-3.10)],桡骨骨折愈合评分系统(radius union scoring system,RUSS)评分高于对照组[I2=99%,P=0.000,MD=0.53,95%CI(0.09,0.98)]; 按补肾活血中药的剂量及药物组成进行亚组分析,补肾活血汤高、低剂量组RUSS评分均高于对照组[I2=0%,P=0.830,MD=0.50,95%CI(0.41,0.59); I2=60%,P=0.110,MD=1.03,95%CI(0.81,1.24)],其他补肾活血中药(非补肾活血汤)组RUSS评分高于对照组[I2=0%,P=0.410,MD=0.83,95%CI(0.74,0.93)]。结论:现有的证据表明,采用口服补肾活血中药治疗老年桡骨远端骨折,能促进骨折愈合、改善腕关节功能。
Abstract:
Objective:To systematically review the clinical curative effects of oral application of Bushen Huoxue(补肾活血,BSHX)traditional Chinese drugs(TCDs)for treatment of distal radius fractures(DRFs)in the aged.Methods:All the randomized controlled trial(RCT)articles about closed reduction splint fixation combined with oral application of BSHX TCDs or open reduction internal fixation(ORIF)combined with oral application of BSHX TCDs(experimental group)versus closed reduction splint fixation or ORIF alone(control group)for treatment of DRFs in the aged included from database establishing to January 2020 were retrieved from China national knowledge internet,WanFang Database,Vip Database,Chinese biomedical literature database,PubMed,Cochrane Library,Web of science,EBSCO and EMbase through computer.The articles were screened and the information was extracted independently by two researchers according to the inclusion and exclusion criteria.The methodological quality of research in the articles was evaluated by using Cochrane bias risk assessment tools,and a Meta-analysis was conducted by using RevMan 5.3 software.Results:One thousand five hundred and sixty-nine articles were searched out.After screening,12 articles(1039 patients)were included in the final analysis,519 patients in control group and 520 patients in experimental group.The results of Meta-analysis revealed that the fracture healing time was shorter,the Gartland-Werley wrist function scores and Patient-Rated Wrist Evaluation(PRWE)scores were lower and the radius union scoring system(RUSS)scores were higher in experimental group compared to control group(I2=0%,P=1.000,MD=-0.77,95%CI(-0.94,-0.59); I2=26%,P=0.190,MD=-2.21,95%CI(-2.43,-1.98); I2=0%,P=1.000,MD=-3.97,95%CI(-4.85,-3.10); I2=99%,P=0.000,MD=0.53,95%CI(0.09,0.98)).The subgroup analysis was conducted according to the doses and ingredients of BSHX TCDs respectively,and the results showed that the RUSS scores were higher in BSHX Tang(补肾活血汤, BSHXT)high- and low-dose group compared to control group(I2=0%,P=0.830,MD=0.50,95%CI(0.41,0.59); I2=60%,P=0.110,MD=1.03,95%CI(0.81,1.24)),and were higher in other BSHX TCDs group(excluding BSHXT)compared to control group(I2=0%,P=0.410,MD=0.83,95%CI(0.74,0.93)).Conclusion:Available evidences suggest that oral application of BSHX TCDs can promote fracture healing and improve wrist function in treatment of DRFs in the aged.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(81674003,81102603); 上海市进一步加快中医药事业发展三年行动计划(2018年-2020年)项目[ZY(2018-2020)-CCCX-2003-05]; 全国中医学术流派传承工作室第二轮建设项目(国中医药人教〔2019〕62号); 上海市临床重点专科建设项目(shslczdzk03901); 上海市2020年度“科技创新行动计划”医学创新研究专项项目(20MC1920600)
通讯作者:庞坚 E-mail:lidazul@126.com 陈博 E-mail:cbm818@126.com
更新日期/Last Update: 1900-01-01