[1]金鑫,谭勇海,张中禹,等.自体细胞生长因子注射联合体外冲击波治疗下肢骨折不愈合的临床研究[J].中医正骨,2018,30(07):10-13.
　JIN Xin,TAN Yonghai,ZHANG Zhongyu,et al.A clinical study of injection of autologous cell growth factors combined with extracorporeal shock wave therapy for treatment of nonunion of lower limb fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(07):10-13.
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自体细胞生长因子注射联合体外冲击波治疗下肢骨折不愈合的临床研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期数:
2018年07期
页码:
10-13
栏目:
临床研究
出版日期:
2018-07-20

文章信息/Info

Title:
A clinical study of injection of autologous cell growth factors combined with extracorporeal shock wave therapy for treatment of nonunion of lower limb fractures
作者:
金鑫; 谭勇海; 张中禹; 鞠昌军; 严伟; 姜红江
(山东省文登整骨医院,山东 威海 264400)
Author(s):
JIN Xin; TAN Yonghai; ZHANG Zhongyu; JU Changjun; YAN Wei; JIANG Hongjiang
The Wendeng Osteopath Hospital,Wendeng 264400,Shandong,China
关键词:
骨折; 不愈合;  体外冲击波治疗;  血管内皮生长因子类;  转化生长因子β
Keywords:
fractures; ununited;  extracorporeal shockwave therapy;  vascular endothelial growth factors;  transforming growth factor beta
摘要:
目的:观察自体细胞生长因子注射联合体外冲击波治疗下肢骨折不愈合的临床疗效。方法:将48例下肢骨折不愈合患者随机分为联合治疗组和冲击波治疗组,每组24例。联合治疗组先向骨折两断端注射以自体外周血制备的细胞生长因子,然后进行体外冲击波治疗; 冲击波治疗组仅进行冲击波治疗。自体细胞生长因子注射和体外冲击波治疗均每隔4 d治疗1次,共治疗3次。治疗结束后定期拍摄X线片,观察骨折愈合情况。结果:制备的细胞生长因子中主要包括血管内皮生长因子、转化生长因子-β,含量分别为(583.87±23.51)pg·mL-1和(195.73±26.08)pg·mL-1。48例患者均获得随访,随访时间3～10个月,中位数4.5个月。治疗后2个月时,2组均有骨折开始愈合的病例,至治疗后10个月时,联合治疗组23例骨折愈合、冲击波治疗组18例骨折愈合,联合治疗组的骨折愈合率高于冲击波治疗组(χ2=4.181,P=0.041)。结论:自体细胞生长因子注射联合体外冲击波能有效治疗下肢骨折不愈合,其效果优于单纯体外冲击波治疗。
Abstract:
Objective:To observe the clinical curative effects of injection of autologous cell growth factors combined with extracorporeal shock wave(ESW)therapy for treatment of nonunion of lower limb fractures.Methods:Forty-eight patients with nonunion of lower limb fractures were randomly divided into combination therapy group and ESW therapy group,24 cases in each group.The cell growth factors prepared by using autologous peripheral blood were injected into both broken ends of fractured bone and then ESW therapy was performed on patients in combination therapy group,while the patients in ESW therapy group were merely treated with ESW therapy.Both injection of autologous cell growth factors and ESW therapy were performed on patients for consecutive 3 times with a 4-day rest-insertion between times.The X-ray films of lower limbs were periodically taken after the end of the treatment,and the fracture healing was observed.Results:The prepared cell growth factors consisted mainly of vascular endothelial growth factor(VEGF)and transforming growth factor-β(TGF-β),which contents were 583.87+/-23.51 and 195.73+/-26.08 pg/mL respectively.All patients were followed up for 3-10 months with a median of 4.5 months.The fractures of some patients began to heal in both of the 2 groups at 2 months after the treatment.The fractures healed in 23 patients of combination therapy group and 18 patients of ESW therapy group at 10 months after the treatment,and the fracture healing rate was higher in combination therapy group compared to ESW therapy group(χ2=4.181,P=0.041).Conclusion:The combination therapy of injection of autologous cell growth factors and ESW therapy can effectively treat nonunion of lower limb fractures,and its curative effect is better than that of monotherapy of ESW.

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备注/Memo

备注/Memo:
基金项目:山东省威海市科技发展计划项目(2017GNS13) 通讯作者:姜红江 E-mail:boneman@163.com
更新日期/Last Update: 2018-11-30