[1]冯巩,徐烨,赵旭,等.脊柱侧弯动物模型制备方法的研究进展[J].中医正骨,2023,35(10):46-49.
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脊柱侧弯动物模型制备方法的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年10期
页码:
46-49
栏目:
综述
出版日期:
2023-10-20

文章信息/Info

作者:
冯巩徐烨赵旭冯其金
天津中医药大学第二附属医院,天津 300150
关键词:
脊柱侧凸 模型动物 综述
摘要:
动物模型制备是科学实验中常用的一种方法,动物模型用于研究人类疾病的成因、发展过程及治疗方法等。目前已知的脊柱侧弯动物模型较多,主要有手术机械类模型、基因类模型、神经肌肉类模型、内分泌类模型。但目前尚没有一种简易、可重复性强、易于推广的脊柱侧弯动物模型制备方法。本文就脊柱侧弯动物模型制备方法的研究进展进行了综述。

参考文献/References:

[1] SUNG P S,PARK M S.Asymmetrical thoracic-lumbar co-ordination during trunk rotation between adolescents with and without thoracic idiopathic scoliosis[J].Spine Deform,2022,10(4):783-790.
[2] SHEN T S,SCHAIRER W,WIDMANN R.In patients with early-onset scoliosis,can growing rods be removed without further instrumentation?An evidenced-based review[J].HSS J,2019,15(2):201-204.
[3] 冯其金,陈文辉,赵玲娟,等.中西医治疗青少年特发性脊柱侧弯的研究进展[J].解放军医药杂志,2021,33(9):110-112.
[4] PASSIAS P G,AHMAD W,TRETIAKOV P,et al.Identifying subsets of patients with adult spinal deformity who maintained a positive response to nonoperative management[J].Neurosurgery,2023,93(2):480-488.
[5] ALMEKKAWI A K,CARUSO J P,EL AHMADIEH T Y,et al.Single nucleotide polymorphisms and adolescent idiopathic scoliosis:a systematic review and meta-analysis of the literature[J].Spine(Phila Pa 1976),2023,48(10):695-701.
[6] SMIT T H.Adolescent idiopathic scoliosis:the mechanobiology of differential growth[J].JOR Spine,2020,3(4):e1115.
[7] WEN J,WANG D,FANG K,et al.Effect of neurocentral cartilage destruction on spinal growth in immature rabbits[J].J Int Med Res,2019,47(2):951-961.
[8] CHEUNG Z B,SELVERIAN S,CHO B H,et al.Idiopathic scoliosis in children and adolescents:emerging techniques in surgical treatment[J].World Neurosurg,2019,130:e737-e742.
[9] HADDAD S,YASUDA T,VILA-CASADEMUNT A,et al.European Spine Study Group.Revision surgery following long lumbopelvic constructs for adult spinal deformity:prospective experience from two dedicated databases[J].Eur Spine J,2023,32(5):1787-1799.
[10] BOBYN J D,LITTLE D G,GRAY R,et al.Animal models of scoliosis[J].J Orthop Res,2015,33(4):458-467.
[11] MEIRING A R,DE KATER E P,STADHOUDER A,et al.Current models to understand the onset and progression of scoliotic deformities in adolescent idiopathic scoliosis:a systematic review[J].Spine Deform,2022,11(3):545-558.
[12] SUNNI N,ASKIN G N,LABROM R D,et al.The effect of vertebral body stapling on spine biomechanics and structure using a bovine model[J].Clin Biomech(Bristol,Avon),2020,74:73-78.
[13] GROSS R H,WU Y,BONTHIUS D J,et al.Creation of a porcine kyphotic mode[J].Spine Deform,2019,7(2):213-219.
[14] LAUBACH L,SHARMA V,ALSUMAIT A,et al.Socioeconomic factors correlation with idiopathic scoliosis curve type and cobb angle severity[J].Cureus,2023,15(2):e34993.
[15] BANALA R R,VEMURI S K,PENKULINTI M,et al.Development of novel animal model for studying scoliosis using a noninvasive method and its validation through gene-expression analysis[J].Asian Spine J,2019,13(1):126-134.
[16] LV X,XU J,JIANG J,et al.Genetic animal models of scoliosis:a systematical review[J].Bone,2021,152:116075.
[17] OLSTAD K,AASMUNDSTAD T,KONGSRO J,et al.Osteochondrosis and other lesions in all intervertebral,articular process and rib joints from occiput to sacrum in pigs with poor back conformation, and relationship to juvenile kyphosis[J].BMC Vet Res,2022,18(1):44.
[18] HALANSKI M A,HILDAHL B,AMUNDSON L A,et al.Maternal diets deficient in vitamin D increase the risk of kyphosis in offspring:a novel kyphotic porcine model[J].J Bone Joint Surg Am,2018,100(5):406-415.
[19] ISAAC C,WRIGHT A,USAS A,et al.Dystrophin and utrophin “double knockout” dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities[J].J Orthop Res,2013,31(3):343-349.
[20] DOS SANTOS J F,LAZZARIN M C,BAPTISTA V I A,et al.Articular cartilage degeneration and bone adaptation due to lack of dystrophin in mice[J].J Bone Miner Metab,2022,40(1):29-39.
[21] HU Z,TANG Z,KIRAM A,et al.The establishment of a mouse model for degenerative kyphoscoliosis based on senescence-accelerated mouse prone 8[J].Oxid Med Cell Longev,2022,2022:7378403.
[22] ASAHINA M,FUJINAWA R,NAKAMURA S,et al.Ngly1-/-rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems[J].Hum Mol Genet,2020,29(10):1635-1647.
[23] VAN GENNIP J L M,BOSWELL C W,CIRUNA B.Neuro-inflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis[J].Sci Adv,2018,4(12):eaav1781.
[24] ASSARAF E,BLECHER R,HEINEMANN-YERUSHALMI L,et al.Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity[J].Nat Commun,2020,11(1):3168.
[25] KAMAL B,RUSSELL D,PAYNE A,et al.Biomechanical properties of bone in a mouse model of Rett syndrome[J].Bone,2015,71:106-114.
[26] ROSE C D,POMPILI D,HENKE K,et al.SCO-spondin defects and neuroinflammation are conserved mechanisms driving spinal deformity across genetic models of idiopathic scoliosis[J].Curr Biol,2020,30(12):2363-2373.
[27] LIU Y,PAN A,HAI Y,et al.Asymmetric biomechanical characteristics of the paravertebral muscle in adolescent idiopathic scoliosis[J].Clin Biomech(Bristol Avon),2019,65:81-86.
[28] XIE D,ZHANG J,DING W,et al.Abnormal change of paravertebral muscle in adult degenerative scoliosis and its association with bony structural parameters[J].Eur Spine J,2019,28(7):1626-1637.
[29] WANG B Y,HSIAO A W,WONG N,et al.Is dexamethasone-induced muscle atrophy an alternative model for nat-urally aged sarcopenia model[J].J Orthop Translat,2022,39:12-20.
[30] 刘立峰,朱悦.实验性脊柱侧凸建模方式的研究进展[J].中国骨与关节外科,2009,2(1):80-85.
[31] GARGANO G,OLIVA F,MIGLIORINI F,et al.Melatonin and adolescent idiopathic scoliosis:the present evidence[J].Surgeon,2022,20(6):e315-e321.
[32] WANG S,LI S,ZHAI X,et al.Transcutaneous auricular vagal nerve stimulation releases extrapineal melatonin and reduces thermal hypersensitivity in Zucker diabetic fatty rats[J].Front Neurosci,2022,16:916822.
[33] ZHANG Z,SILVEYRA E,JIN N,et al.A congenic line of the C57BL/6J mouse strain that is proficient in melatonin synthesis[J].J Pineal Res,2018,65(3):e12509.
[34] LIU H,LIU Z,MAN C W,et al.The effect of exogenous melatonin on reducing scoliotic curvature and improving bone quality in melatonin-deficient C57BL/6J mice[J].Sci Rep,2019,9(1):6202.
[35] YANG S,ZHENG C,JIANG J,et al.The value of applying a melatonin antagonist(Luzindole)in improving the success rate of the bipedal rat scoliosis model[J].BMC Musculoskelet Disord,2017,18(1):137.
[36] WU Y T,TANG M X,WANG Y J,et al.Lower androgen levels promote abnormal cartilage development in female patients with adolescent idiopathic scoliosis[J].Ann Transl Med,2021,9(9):784.
[37] LI J,LI N,CHEN Y,et al.SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells[J].Cell Death Dis,2019,10(11):805.

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备注/Memo

备注/Memo:
基金项目:天津市科技计划项目(20JCYBJC00340)
通讯作者:冯其金 E-mail:fengqijin@126.com
更新日期/Last Update: 1900-01-01