参考文献/References:
[1] 中华医学会血液学分会血栓与止血学组、中国血友病协作组.血友病诊断与治疗中国专家共识(2017年版)[J].中华血液学杂志,2016,37(5):364-370.
[2] BHARDWAJ R,RATH G,GOYAL A K.Advancement in the treatment of haemophilia[J].Int J Biol Macromol,2018,118(Pt A):289-295.
[3] HANLEY J,MCKERNAN A,CREAGH M D,et al.Guidelines for the management of acute joint bleeds and chronic synovitis in haemophilia:a United Kingdom Haemophilia Centre Doctors’ Organisation(UKHCDO)guideline[J].Haemophilia,2017,23(4):511-520.
[4] KASHIWAKURA Y,OHMORI T,MIMURO J,et al.Intra-articular injection of mesenchymal stem cells expressing coagulation factor ameliorates hemophilic arthropathy in factor Ⅷ-deficient mice[J].J Thromb Haemost,2012,10(9):1802-1813.
[5] RODRIGUEZ-MERCHAN E C.Intra-articular injections of mesenchymal stem cells(MSCs)as a treatment for hemophilic arthropathy[J].Expert Rev Hematol,2016,9(8):737-741.
[6] VANNABOUATHONG C,DEL FABBRO G,SALES B,et al.Intra-articular injections in the treatment of symptoms from ankle arthritis:a systematic review[J].Foot Ankle Int,2018,39(10):1141-1150.
[7] OHMORI T,MIZUKAMI H,KATAKAI Y,et al.Safety of intra-articular transplantation of lentivirally transduced mesenchymal stromal cells for haemophilic arthropathy in a non-human primate[J].Int J Hematol,2018,108(3):239-245.
[8] MATSUI H,SHIBATA M,BROWN B,et al.Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor Ⅷ expression from lentivirally engineered endothelial progenitors[J].Stem Cells,2007,25(10):2660-2669.
[9] FOMIN M E,TOGARRATI P P,MUENCH M O.Progress and challenges in the development of a cell-based therapy for hemophilia A[J].J Thromb Haemost,2014,12(12):1954-1965.
[10] LYU C,SHEN J,WANG R,et al.Targeted genome engineering in human induced pluripotent stem cells from patients with hemophilia B using the CRISPR-Cas9 system[J].Stem Cell Res Ther,2018,9(1):92.
[11] 王大威.基于干细胞的靶向血小板基因治疗血友病A的研究[D].上海:上海交通大学,2017.
[12] YOSHIHARA M,OGUCHI A,MURAKAWA Y.Genomic instability of iPSCs and challenges in their clinical applications[J].Adv Exp Med Biol,2019,1201:23-47.
[13] VASKO T,FROBEL J,LUBBERICH R,et al.IPSC-derived mesenchymal stromal cells are less supportive than primary MSCs for co-culture of hematopoietic progenitor cells[J].J Hematol Oncol,2016,9:43.
[14] 王韵,施小凤,毛建华,等.靶向血小板表达FⅧ基因治疗血友病A的新进展[J].国际输血及血液学杂志,2020,43(1):17-22.
[15] BAUMGARTNER C K,MATTSON J G,WEILER H,et al.Targeting factor Ⅷexpression to platelets for hemophilia A gene therapy does not induce an apparent thrombotic risk in mice[J].J Thromb Haemost,2017,15(1):98-109.
[16] NATHWANI A C,TUDDENHAM E G,RANGARAJAN S,et al.Adenovirus-associated virus vector-mediated gene transfer in hemophilia B[J].N Engl J Med,2011,365(25):2357-2365.
[17] IORIO A,HALIMEH S,HOLZHAUER S,et al.Rate of inhibitor development in previously untreated hemophilia a patients treated with plasma-derived or recombinant factorⅧconcentrates:a systematic review[J].J Thromb Haemost,2010,8(6):1256-1265.
[18] BUNTING S,ZHANG L,XIE L,et al.Gene therapy with BMN 270 results in therapeutic levels of FⅧ in mice and primates and normalization of bleeding in hemophilic mice[J].Mol Ther,2018,26(2):496-509.
[19] LONG B R,VERON P,KURANDA K,et al.Early phase clinical immunogenicity of valoctocogene roxaparvovec,an AAV5-mediated gene therapy for hemophilia A[J].Mol Ther,2021,29(2):597-610.
[20] AGBOOLA F,RIND D M,WALTON S M,et al.The effectiveness and value of emicizumab and valoctocogene roxaparvovec for the management of hemophilia A without inhibitors[J].J Manag Care Spec Pharm,2021,27(5):667-673.
[21] NIJDAM A,FOPPEN W,VAN DER SCHOUW Y T,et al.Long-term effects of joint bleeding before starting prophylaxis in severe haemophilia[J].Haemophilia,2016,22(6):852-858.
[22] KASHIWAKURA Y,OHMORI T,MIMURO J,et al.Intra-articular injection of mesenchymal stem cells expressing coagulation factor ameliorates hemophilic arthropathy in factor Ⅷdeficient mice[J].J Thromb Haemost,2012,10(9):1802-1813.
[23] 王志伟,索海强,梁寒光,等.不同来源的间充质干细胞在早期骨关节炎中治疗的特点比较及展望[J].中华老年骨科与康复电子杂志,2020,6(6):364-369.
[24] PULLES A E,MASTBERGEN S C,SCHUTGENS R E,et al.Pathophysiology of hemophilic arthropathy and potential targets for therapy[J].Pharmacol Res,2017,115:192-199.
[25] JIANG W,XU J.Immune modulation by mesenchymal stem cells[J].Cell Prolif,2020,53(1):e12712.
[26] KRAMPERA M.Mesenchymal stromal cell “icensing”:a multistep process[J].Leukemia, 2011,25(9):1408-1414.
[27] NAUTA A J,KRUISSELBRINK A B,LURVINK E,et al.Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells[J].J Immunol,2006,177(4):2080-2087.
[28] ABUMAREE M H,AL JUMAH M A,KALIONIS B,et al.Human placental mesenchymal stem cells(pMSCs)play a role as immune suppressive cells by shifting macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages[J].Stem Cell Rev Rep,2013,9(5):620-641.
[29] CHOI H, LEE R H,BAZHANOV N,et al.Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages[J].Blood,2011,118(2):330-338.
[30] 张纯希,李想,周钰翔,等.骨骼微环境中谁决定间充质干细胞的分化命运[J].中国组织工程研究,2021,25(25):4045-4052.
[31] HUANG G,LI F,ZHAO X,et al.Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment[J].Chem Rev,2017,117(20):12764-12850.
[32] ZHANG S,CHUAH S J,LAI R C,et al.MSC exosomes mediate cartilage repair by enhancing proliferation,attenuating apoptosis and modulating immune reactivity[J].Biomaterials,2018,156:16-27.
[33] GURUNATHAN S,KANG M H,JEYARAJ M,et al.Review of the isolation,characterization,biological function,and multifarious therapeutic approaches of exosomes[J].Cells,2019,8(4):307.
[34] GANGADHARAN B,PARKER E T,IDE L M, et al.High-level expression of porcine factor Ⅷ from genetically modified bone marrow-derived stem cells[J].Blood,2006,107(10):3859-3864.
相似文献/References:
[1]邓伟哲,王宏晶,王宇恒,等.微创针刀镜治疗难治性膝关节类风湿关节炎[J].中医正骨,2015,27(11):42.
[2]李艺彬,朱勇,吴昭克.关节镜下多入路全关节滑膜清理术治疗肘关节类风湿关节炎[J].中医正骨,2015,27(11):56.
[3]齐新宇,向黎黎,熊辉,等.基于高蛋白饮食建立鸡痛风性关节炎模型的量效关系研究[J].中医正骨,2015,27(02):1.
QI Xinyu,XIANG Lili,XIONG Hui,et al.A dose-effect relationship study of gouty arthritis chicken model built by high-protein diet[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):1.
[4]齐新宇,熊辉,周彪,等.蠲痹历节清方干预鸡急性痛风性关节炎模型的
实验研究[J].中医正骨,2015,27(03):5.
QI Xinyu,XIONG Hui,ZHOU Biao,et al.Juanbilijieqing Fang(蠲痹历节清方)interfere with acute gouty arthritis chiken model[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):5.
[5]胡钢锋,肖鲁伟,童培建.关节液代谢组学在类风湿关节炎诊断
及寒热证候分型中的应用[J].中医正骨,2015,27(01):5.
HU Gangfeng,XIAO Luwei,TONG Peijian.Application of joint fluid metabolomics to diagnosis and COLD-HEAT SYMPTOM COMPLEX typing in patients with rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(07):5.
[6]熊辉,曲良烨,向黎黎,等.痛风性关节炎湿热证病证结合模型的建立[J].中医正骨,2014,26(03):14.
Xiong Hui*,Qu Liangye,Xiang Lili,et al.A rat model of gouty arthritis combined with dampness-heat syndrome[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(07):14.
[7]孙克民,王平,卢启贵,等.关节镜下滑膜切除术联合中药口服
治疗早期膝关节类风湿关节炎[J].中医正骨,2013,25(09):39.
[8]李峰,郭艳幸,曹向阳,等.贯叶连翘灌胃联合光动力疗法对类风湿关节炎白兔膝关节滑膜组织病理形态的影响[J].中医正骨,2014,26(09):6.
Li Feng*,Guo Yanxing,Cao Xiangyang,et al.Effect of intragastric administration of hypericum perforatum combined with photodynamic therapy on the pathological morphology of synovial tissue of knee joints in rabbits with rheumatoid arthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(07):6.
[9]严超,刘喜德,张金禄,等.蜂针疗法治疗膝骨性关节炎的护理[J].中医正骨,2013,25(01):74.
[10]王笑青,张永红,侯宏理,等.顽痹清丸联合非甾体抗炎药及改善病情的抗风湿药治疗湿热痹阻型类风湿关节炎[J].中医正骨,2013,25(03):41.
WANG Xiao-qing*,ZHANG Yong-hong,HOU Hong-li,et al.Curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs and disease modifying antirheumatic drugs in the treatment of rheumatoid arthritis of dampness-heat stagnation type[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(07):41.
[11]王彭禾,汪小健,吴丛姿,等.血友病性关节炎与骨质疏松症的关系研究[J].中医正骨,2022,34(02):31.
.The First Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 00,Zhejiang,et al.WANG Penghe1,WANG Xiaojian1,WU Congzi1,SHI Zhenyu1,JIN Hongting1,WANG Pinger1,TONG Peijian2[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2022,34(07):31.