[1]张厚建,张维新,童培建.间充质干细胞来源外泌体治疗骨关节炎和软骨损伤的研究进展[J].中医正骨,2020,32(06):49-58.
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间充质干细胞来源外泌体治疗骨关节炎和软骨损伤的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第32卷
期数:
2020年06期
页码:
49-58
栏目:
综 述
出版日期:
2020-06-20

文章信息/Info

作者:
张厚建1张维新1童培建2
(1.浙江中医药大学第一临床医学院,浙江杭州310053; 2.浙江省中医院,浙江杭州310006)
关键词:
骨关节炎 软骨 间质干细胞 外泌体 综述
摘要:
骨关节炎是临床常见病,以关节软骨损伤、软骨下骨硬化及滑膜炎症等为特征,可导致患肢疼痛、畸形和功能障碍。外泌体是细胞间通讯的主要载体,在细胞间转运具有生物活性的脂质、核酸及蛋白质,从而改变受体细胞的生物学功能。间充质干细胞来源外泌体具有抗炎、免疫调节及促进组织修复和再生等作用,是治疗骨关节炎和软骨损伤的新靶点。本文对间充质干细胞及外泌体进行了概述,并对间充质干细胞来源外泌体在骨关节炎和软骨损伤治疗中的应用及其作用机制进行了综述。

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备注/Memo

备注/Memo:
(收稿日期:2020-03-13本文编辑:郭毅曼)通讯作者:童培建E-mail:tongpeijian@163.com
更新日期/Last Update: 2020-10-10