[1]熊巍,吴忌,喻衫.祛风寒湿洗剂薰洗治疗膝骨关节炎风寒湿痹证[J].中医正骨,2019,31(02):74-76.
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祛风寒湿洗剂薰洗治疗膝骨关节炎风寒湿痹证()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年02期
页码:
74-76
栏目:
临床报道
出版日期:
2019-02-20

文章信息/Info

作者:
熊巍; 吴忌; 喻衫
(四川省骨科医院,四川 成都 610041)
关键词:
骨关节炎; 膝;  痹证;  薰洗;  白细胞介素17
摘要:
目的:观察祛风寒湿洗剂薰洗治疗膝骨关节炎(knee osteoarthritis,KOA)风寒湿痹证的临床疗效和安全性,并探讨其可能的作用机制。方法:2016年1—12月收治40例KOA风寒湿痹证患者,均采用祛风寒湿洗剂薰洗治疗,每日2次,连续治疗4周。分别于治疗前、治疗开始后1、3、6、12个月评定患者的膝关节疼痛视觉模拟量表(visual analogue scale,VAS)评分、美国膝关节学会评分(the Knee Society Score,KSS),测定血浆及关节液中白细胞介素(interleukin-17,IL-17)含量,观察治疗期间并发症的发生情况。结果:治疗过程中,患者均未出现皮肤过敏、烫伤等并发症。患者治疗前后不同时点的膝关节疼痛VAS评分、KSS、血浆及关节液 IL-17含量比较,差异均有统计学意义[VAS评分:(6.64±1.65)分,(3.26±1.43)分,(3.58±1.72)分,(3.74±1.54)分,(3.95±1.73)分,F=28.609,P=0.000; KSS:(56.41±8.75)分,(89.23±8.58)分,(87.69±8.65)分,(84.57±8.39)分,(80.53±9.72)分,F=95.529,P=0.000; 血浆IL-17含量:(6.61±1.78)pg·mL-1,(4.17±1.52)pg·mL-1,(4.57±1.65)pg·mL-1,(4.86±1.59)pg·mL-1,(5.15±1.76)pg·mL-1,F=12.592,P=0.000; 关节液 IL-17含量:(7.44±1.57)pg·mL-1,(5.23±1.86)pg·mL-1,(5.58±1.62)pg·mL-1,(5.77±1.81)pg·mL-1,(5.95±1.64)pg·mL-1,F=9.983,P=0.000]。治疗开始后1、3、6、12个月时患者的膝关节疼痛VAS评分均低于治疗前(P=0.000,P=0.000,P=0.000,P=0.000),KSS均高于治疗前(P=0.000,P=0.000,P=0.000,P=0.000),血浆及关节液 IL-17含量均低于治疗前(血浆IL-17含量:P=0.000,P=0.000,P=0.000,P=0.000; 关节液IL-17含量:P=0.000,P=0.000,P=0.000,P=0.000); 随着时间延长,治疗开始后各时点的VAS评分逐渐增高(P=0.000,P=0.000,P=0.000),KSS逐渐降低(P=0.000,P=0.000,P=0.000),血浆及关节液 IL-17含量均逐渐增高(血浆IL-17含量:P=0.000,P=0.000,P=0.000; 关节液IL-17含量:P=0.000,P=0.000,P=0.000)。结论:祛风寒湿洗剂薰洗治疗KOA风寒湿痹证,可有效减轻患者的膝关节疼痛症状,改善膝关节功能,安全性较高,但随着时间延长,疗效逐渐减弱; 其作用机制可能与降低血浆及关节液中的IL-17含量有关。

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备注/Memo

备注/Memo:
通讯作者:熊巍 E-mail:459440204@qq.com(收稿日期:2018-10-10 本文编辑:李晓乐)
更新日期/Last Update: 2019-02-20