[1]贺旭峰,何翔,田广军.丹参多酚酸盐注射液静脉滴注联合甲氨蝶呤口服治疗银屑病关节炎[J].中医正骨,2016,28(05):61-62.
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丹参多酚酸盐注射液静脉滴注联合甲氨蝶呤口服治疗银屑病关节炎()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期数:
2016年05期
页码:
61-62
栏目:
临床报道
出版日期:
2016-05-20

文章信息/Info

作者:
贺旭峰; 何翔; 田广军
上海中医药大学附属曙光医院,上海 201203
关键词:
关节炎; 牛皮癣;  银屑病;  碱性磷酸酶;  丹参多酚酸盐;  甲氨蝶呤
摘要:
目的:观察丹参多酚酸盐注射液静脉滴注联合甲氨蝶呤口服治疗银屑病关节炎的临床疗效,探讨其可能的作用机制。方法:2014年1月至2015年6月,采用丹参多酚酸盐注射液静脉滴注联合甲氨蝶呤口服治疗银屑病关节炎患者12例,男6例、女6例。年龄35～62岁,中位数45岁。所有患者均符合Moll-Wright关节病型银屑病诊断标准,同时排除关节严重畸形丧失活动能力者。病程4～30年,中位数14年。连续治疗6周。观察治疗前后关节症状体征、皮损及血清碱性磷酸酶含量的变化情况。结果:按照《中药新药临床研究指导原则》中的症状体征分级,治疗前关节压痛重1例、中9例、轻2例,治疗6周后关节压痛中2例、轻8例、无2例; 治疗前关节肿胀重2例、中4例、轻6例,治疗6周后关节压痛中1例、轻6例、无5例; 治疗前关节屈伸不利重1例、中7例、轻4例,治疗6周后关节压痛中3例、轻9例。治疗6周后银屑病皮损面积及严重性指数评分由治疗前(11.25±1.60)分降至(4.50±1.38)分。治疗前血清碱性磷酸酶含量(121.15±11.57)U·L-1,治疗3周后升至(141.83±12.19)U·L-1,治疗6周后降至(101.58±6.88)U·L-1。参照《中药新药临床研究指导原则》中银屑病关节炎的疗效标准评价疗效,显效5例、有效6例、无效1例。结论:丹参多酚酸盐注射液静脉滴注联合甲氨蝶呤口服治疗银屑病关节炎,能够缓解关节疼痛、肿胀及屈伸不利,缩小皮损范围,疗效确切,其作用机制可能与血清碱性磷酸酶有关。

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更新日期/Last Update: 2016-10-30