[1]吴昭克,朱勇,李艺彬,等.壮骨通痹丸与硫酸氨基葡萄糖治疗 膝骨关节炎的比较研究[J].中医正骨,2012,24(07):20-22.
　WU Zhao-ke*,ZHU Yong,LI Yi-bin,et al.Comparative study on the curative effects and safety between ZHUANGGU TONGBI pill and glucosamine sulfate capsules in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(07):20-22.
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壮骨通痹丸与硫酸氨基葡萄糖治疗 膝骨关节炎的比较研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期数:
2012年07期
页码:
20-22
栏目:
临床研究
出版日期:
2012-07-30

文章信息/Info

Title:
Comparative study on the curative effects and safety between ZHUANGGU TONGBI pill and glucosamine sulfate capsules in the treatment of knee osteoarthritis
作者:
吴昭克; 朱勇; 李艺彬; 徐福东
福建省泉州市正骨医院,福建 泉州 362000
Author(s):
WU Zhao-ke*; ZHU Yong; LI Yi-bin; XU Fu- dong.*
Quanzhou Osteopathy Hospital,Quanzhou 362000,Fujian,China
关键词:
骨关节炎; 膝 壮骨通痹丸 硫酸氨基葡萄糖 治疗; 临床研究性
Keywords:
Osteoarthritis; knee;  ZHUANGGU TONGBI PILL;  Glucosamine sulfate;  Therapies; investigational
摘要:
目的:观察对比壮骨通痹丸与硫酸氨基葡萄糖治疗膝骨关节炎的临床疗效和安全性。方法:将符合要求的120例患者随机分 成治疗组和对照组,每组60例。治疗组口服壮骨通痹丸治疗,对照组口服硫酸氨基葡萄糖胶囊治疗,共治疗12周。治疗后观察对比 2组患者的Lequesne指数、临床疗效及不良反应发生情况。结果:①Lequesne指数。治疗前2组患者Lequesne指数比较,差异无统 计学意义(t=0.954,P=0.348); 治疗后2组患者的Lequesne指数均减少,其中治疗组减少程度更明显(t=6.228,P=0.000)。②临床 疗效。治疗后2组患者的症状体征均改善,治疗组临床疗效优于对照组(χ2=7.026,P=0.008)。③不良反应。治疗期 间2组患者均未出现过敏反应。治疗组2例患者出现便秘,1例患者血压升高,1例患者心率加快; 对照组3例患者出现恶心、便秘,1 例患者心率加快,1例轻度肝功能受损。经对症处理后,2组患者的不良反应均消失。2组患者不良反应发生率比较,差异无统计学 意义(χ2=0.100,P=0.752)。结论:壮骨通痹丸能明显改善膝骨关节炎患者的临床症状体征及关节功能,且治疗期间 无严重不良反应,具有一定的临床应用价值。
Abstract:
Objective:To observe and compare the clinical curative effects and safety between ZHUANGGU TONGBI pill and glucosamine sulfate capsules in the treatment of knee osteoarthritis(KOA).Methods:One hundred and twenty patients met the requirements were randomly divided into treatment group and control group,60 cases in each group.Patients in the treatment group were administrated with ZHUANGGU TONGBI pill,while the others in the control group were administrated with glucosamine sulfate capsules,treatment of 12 weeks in total.Lequesne index,clinical curative effects and adverse reactions during the treatment period of the patients were observed and compared between the 2 groups after the treatment.Results:①There was no statistical difference in Lequesne index between the 2 groups before the treatment(t=0.954,P=0.348); after the treatment, the Lequesne index of the 2 groups were all reduced and that of the treatment group reduced more(t=6.228,P=0.000).②After the treatment,symptoms and signs of patients in the 2 groups were all improved,and clinical curative effect of treatment group was better than that of control group(χ2=7.026,P=0.008).③No anaphylaxis was found in the 2 groups during the treatment period.Two patients with constipation,1 case with increased blood pressure and 1 case with elevated heart rate were found in the treatment group; while 3 cases with nausea and constipation,1 case with elevated heart rate and 1 case with lightly impaired liver function were found in the control group.After symptomatic treatment,the adverse reactions of the 2 groups were all disappeared.There was no statistical difference in adverse reaction ratio between the 2 groups (χ2=0.100,P=0.752).Conclusion:ZHUANGGU TONGBI pill can significantly improve the clinical symptoms and signs and the joint functions for the KOA patients without serious adverse reactions during the treatment period,therefore,it has a certain application value in the treatment of KOA.

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备注/Memo

备注/Memo:
2012-01-13收稿 2012-04-18修回
更新日期/Last Update: 2012-07-30