[1]王羿翔,黄衠,张磊,等.慢性骨髓炎患者发生下肢深静脉血栓形成的影响因素分析[J].中医正骨,2024,36(12):20-23.
　WANG Yixiang,HUANG Zhun,ZHANG Lei,et al.Factors influencing lower limb deep venous thrombosis in patients with chronic osteomyelitis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2024,36(12):20-23.
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慢性骨髓炎患者发生下肢深静脉血栓形成的影响因素分析()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第36卷
期数:
2024年12期
页码:
20-23
栏目:
临床研究
出版日期:
2024-12-20

文章信息/Info

Title:
Factors influencing lower limb deep venous thrombosis in patients with chronic osteomyelitis
作者:
王羿翔1; 黄衠2; 张磊2; 杨红萍3; 陈香3; 邢林波2
1.广西中医药大学研究生院,广西 南宁 530200; 2.河南省洛阳正骨医院/河南省骨科医院,河南 洛阳 471002; 3.福建中医药大学护理学院,福建 福州 350122
Author(s):
WANG Yixiang1; HUANG Zhun2; ZHANG Lei2; YANG Hongping3; CHEN Xiang3; XING Linbo2
1.Postgraduate College of Guangxi University of Chinese Medicine,Nanning 530200,Guangxi,China 2.Luoyang Orthopedic-Traumatological Hospital,Luoyang 471002,Henan,China 3.School of Nursing,Fujian University of Traditional Chinese Medicine,Fuzhou,350122,Fujian,China
关键词:
骨髓炎;  静脉血栓形成;  危险因素;  Logistic模型
Keywords:
osteomyelitis;  venous thrombosis;  risk factors;  logistic models
摘要:
目的:探讨慢性骨髓炎(chronic osteomyelitis,CO)患者发生下肢深静脉血栓形成(deep venous thrombosis,DVT)的影响因素。方法:选择2022年1月至2023年6月采用手术治疗的288例CO患者,从病历系统中提取患者的年龄、性别、体质量指数、吸烟史、饮酒史、合并糖尿病情况、合并高血压病情况、病因、四肢血栓史,以及术前口服补益气血、清热利湿类中药和采用活血消肿、去腐生肌类中药泡洗情况等信息。根据超声检查结果,按照是否发生下肢DVT分为2组。先进行单因素分析,再以单因素分析中组间差异有统计学意义的因素作为自变量,以是否发生下肢DVT为因变量进行Logistic回归分析。结果:①单因素分析结果。DVT组26例、非DVT组262例。2组患者年龄、合并糖尿病情况、合并高血压病情况、四肢血栓史,以及术前口服补益气血、清热利湿类中药情况的组间差异均有统计学意义(χ2=6.439,P=0.011; χ2=17.720,P=0.000; χ2=22.959,P=0.000; χ2=11.909,P=0.001; χ2=9.421,P=0.002)。②多因素分析结果。Logistic回归分析结果显示,合并糖尿病、合并高血压病、有四肢血栓史均为CO患者发生下肢DVT的危险因素[B=1.208,P=0.025,OR=3.346,95%CI(1.140,9.553); B=1.889,P=0.000,OR=6.614,95%CI(2.449,18.590); B=2.048,P=0.001,OR=7.753,95%CI(2.310,26.560)],术前口服补益气血、清热利湿类中药是其保护因素[B=-3.190,P=0.004,OR=0.041,95%CI(0.002,0.243)]。结论:有四肢血栓史、合并糖尿病、合并高血压病均为CO患者发生下肢DVT的危险因素,术前口服补益气血、清热利湿类中药是CO患者发生下肢DVT的保护因素。
Abstract:
Objective:To explore the factors influencing lower limb deep venous thrombosis(LDVT)in patients with chronic osteomyelitis(CO).Methods:The medical records of patients who underwent surgery for CO from January 2022 to June 2023 were selected and re-trospectively analyzed.Based on the results of the ultrasound examination,the included patients were divided into DVT group and non-DVT group according to whether the LDVT was found.The information of the patients,including age,gender,body mass index,smoking history,alcohol-drinking history,whether combined with diabetes mellitus,whether combined with hypertension,etiopathogenisis,history of limb thrombosis,preoperative oral application of reinforcing qi-blood,clearing heat and dissolving dampness traditional Chinese drugs(TCDs),lower limb-soaking with the TCDs for promoting blood circulation and alleviating swelling,as well as eliminating necrotic tissues and promoting granulation,was extracted from the Electronic Medical Record System(EMRS).A single-factor analysis was conducted on the extracted information of patients in the 2 groups to screen the factors with statistically significant differences between the 2 groups,followed by a multi-factor logistic regression analysis with the screened factors as independent variables,and whether the LDVT was found as the depen-dent variable.Results:①The single-factor analysis.Two hundred and eighty-eight CO patients were enrolled in the study,with 26 ones in the DVT group and 262 ones in the non-DVT group.The single factor analysis showed that the differences were statistically significant between the 2 groups in age,whether combined with diabetes mellitus,whether combined with hypertension,history of limb thrombosis,and preoperative oral application of reinforcing qi-blood,clearing heat and dissolving dampness TCDs(χ2=6.439,P=0.011; χ2=17.720,P=0.000; χ2=22.959,P=0.000; χ2=11.909,P=0.001; χ2=9.421,P=0.002).②The multi-factor logistic regression analysis.The multi-factor logistic regression analysis revealed that combined with diabetes mellitus,combined with hypertension,and having the history of limb thrombosis were the risk factors for LDVT in CO patients(B=1.208,P=0.025,OR=3.346,95%CI(1.140,9.553); B=1.889,P=0.000,OR=6.614,95%CI(2.449,18.590); B=2.048,P=0.001,OR=7.753,95%CI(2.310,26.560)),whereas,the preoperative oral application of reinforcing qi-blood,clearing heat and dissolving dampness TCDs was the protective factor for LDVT in CO patients(B=-3.190,P=0.004,OR=0.041,95%CI(0.002,0.243)).Conclusion:Having the history of limb thrombosis,combined with diabetes mellitus,and combined with hypertension are all the risk factors for LDVT in CO patients,whereas,the preoperative oral application of reinforcing qi-blood,clearing heat and dissolving dampness TCDs is the protective factor for LDVT in CO patients.

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备注/Memo

备注/Memo:
基金项目:河南省中医药科学研究专项课题(2022ZY1132)
通讯作者:邢林波 E-mail:450078536@qq.com
更新日期/Last Update: 1900-01-01