[1]朱云森,江敞,李俊.氨甲环酸对老年股骨转子间骨折髓内固定术 围手术期隐性失血的影响[J].中医正骨,2015,27(06):16-18.
 ZHU Yunsen,JIANG Chang,LI Jun.Effect of tranexamic acid on perioperative hidden blood loss in aged patients receiving intramedullary fixation for treatment of intertrochanteric fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(06):16-18.
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氨甲环酸对老年股骨转子间骨折髓内固定术 围手术期隐性失血的影响()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第27卷
期数:
2015年06期
页码:
16-18
栏目:
临床研究
出版日期:
2015-06-30

文章信息/Info

Title:
Effect of tranexamic acid on perioperative hidden blood loss in aged patients receiving intramedullary fixation for treatment of intertrochanteric fractures
作者:
朱云森江敞李俊
浙江省温岭市第一人民医院,浙江 温岭 317500
Author(s):
ZHU YunsenJIANG ChangLI Jun
The Wenling First People's Hospital,Wenling 317500,Zhejiang,China
关键词:
失血手术 氨甲环酸 髋骨折 转子间骨折 骨折固定术髓内 股骨近端防旋髓内钉 静脉血栓形成 治疗临床研 究性
Keywords:
blood losssurgical tranexamic acid hip fractures intertrochanteric fractures fracture fixationintramedullary proximal femoral nail antirotation venous thrombosis therapiesinvestigational
摘要:
目的:探讨氨甲环酸对老年股骨转子间骨折髓内固定术围手术期隐性失血的影响。方法:将83例符合要求的老年股骨转子 间骨折患者随机分为2组,氨甲环酸组43例、常规组40例。所有患者的手术均由同一组医生完成,均采用股骨近端防旋髓内钉内固 定治疗,氨甲环酸组患者分别于入院当天和手术开始前静脉滴注氨甲环酸(10 mg·kg-1)1次。测定2组患者的失血量 ,并观察术后深静脉血栓形成情况。结果:2组患者手术时间、显性失血量比较,组间差异均无统计学意义[(32.58±5.12) min,(31.90±8.73)min,t=0.437,P=0.110;(89.67±15.24)mL,(97.60±14.65)mL,t=2.410,P=0.794]; 氨甲环酸组 术前及术后隐性失血量均少于常规组[(84.91±13.66)mL,(154.08±26.99)mL,t=14.883,P=0.000; (158.23±30.16)mL,(286.15±59.61)mL,t=12.460,P=0.013]。2组均未出现深静脉血栓形成病例。结论:应用氨甲环酸 可有效减少老年股骨转子间骨折髓内固定术围手术期隐性失血,而且具有较高的安全性。
Abstract:
Objective:To explore the effect of tranexamic acid on perioperative hidden blood loss in aged patients receiving intramedullary fixation for treatment of intertrochanteric fractures.Methods:Eighty-three aged patients with intertrochanteric fractures enrolled in the study were randomly divided into tranexamic acid group(43 cases)and conventional group(40 cases).All patients were treated with proximal femoral nail antirotation(PFNA)internal fixation by the same group of surgeons.Intravenous drip infusions of tranexamic acid(10 mg/kg)were performed on patients in tranexamic acid group on the day of admission and before the start of the surgery respectively.Then the blood loss were measured and compared between the 2 groups and the postoperative deep vein thrombosis were also recorded.Results:There was no statistical difference in operation time and dominant blood loss between the 2 groups(32.58+/-5.12 vs 31.90+/-8.73 min,t=0.437,P=0.110; 89.67+/- 15.24 vs 97.60+/-14.65 mL,t=2.410,P=0.794),while hidden blood loss was less in the tranexamic acid group compared to the conventional group before and after the operation(84.91+/-13.66 vs 154.08+/-26.99 mL,t=14.883,P=0.000; 158.23+/-30.16 vs 286.15+/-59.61 mL,t=12.460,P=0.013).Deep venous thrombosis was not found in both of the 2 groups.Conclusion:Application of tranexamic acid can effectively reduce perioperative hidden blood loss in aged patients receiving intramedullary fixation for treatment of intertrochanteric fractures,meanwhile it has high safety.

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备注/Memo

备注/Memo:
2015-03-12收稿 2015-03-24修回
更新日期/Last Update: 2015-06-30