[1]毛俊杰,徐涛涛,童培建.神经生长因子/原肌球蛋白受体激酶A信号通路与骨折疼痛和骨折愈合的关系研究进展[J].中医正骨,2023,35(03):50-54,64.
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神经生长因子/原肌球蛋白受体激酶A信号通路与骨折疼痛和骨折愈合的关系研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年03期
页码:
50-54,64
栏目:
综述
出版日期:
2023-03-20

文章信息/Info

作者:
毛俊杰1徐涛涛2童培建2
(1.浙江中医药大学第一临床医学院,浙江 杭州 310053; 2.浙江省中医院,浙江 杭州 310006)
关键词:
骨折 疼痛 骨折愈合 神经生长因子 原肌球蛋白受体激酶A 综述
摘要:
骨折是骨科最常见的一类疾病。疼痛是骨折患者的首发症状,且较剧烈。临床上常用的止痛药物——非甾体抗炎药(non-steroidal anti-inflammatory drug,NSAID)和麻醉性镇痛药均能有效缓解骨折疼痛,但是症状容易反复,而且上述药物具有一定程度的不良反应。近年来的研究显示,神经生长因子(nerve growth factor,NGF)/原肌球蛋白受体激酶A(tropomyosin receptor kinase A,TRKA)信号通路与骨折疼痛的产生与传导密切相关,阻断或抑制该信号通路能明显缓解骨折疼痛,但该信号通路与骨折愈合的关系尚不明确。目前针对NGF/TRKA信号通路研发的药物表现出较好的缓解骨折疼痛的作用,有望成为临床上治疗骨折疼痛的新选择。本文就NGF/TRKA信号通路与骨折疼痛和骨折愈合之间关系的研究进展进行了综述。

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备注/Memo

备注/Memo:
通讯作者:童培建 E-mail:tongpeijian@163.com
更新日期/Last Update: 1900-01-01