[1]徐道情,黄维琛,欧梁,等.基于中医传承辅助平台挖掘《正体类要》中治伤内服方剂的用药规律[J].中医正骨,2021,33(12):14-18.
　XU Daoqing,HUANG Weichen,OU Liang,et al.A data mining-based analysis of clinical medication rules of oral prescriptions for treatment of orthopedic and traumatic diseases in Classification and Treatment of Traumatic Diseases using traditional Chinese medicine inheritance support system[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(12):14-18.
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基于中医传承辅助平台挖掘《正体类要》中治伤内服方剂的用药规律()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第33卷
期数:
2021年12期
页码:
14-18
栏目:
文献研究
出版日期:
2021-12-20

文章信息/Info

Title:
A data mining-based analysis of clinical medication rules of oral prescriptions for treatment of orthopedic and traumatic diseases in Classification and Treatment of Traumatic Diseases using traditional Chinese medicine inheritance support system
作者:
徐道情1; 黄维琛2; 欧梁2; 孔德忠1; 杨先宇1; 付兴前1
(1.贵州中医药大学骨伤学院,贵州 贵阳 550002; 2.贵州中医药大学第二附属医院,贵州 贵阳 550003)
Author(s):
XU Daoqing1; HUANG Weichen2; OU Liang2; KONG Dezhong1; YANG Xianyu1; FU Xingqian1
1.The College of Traumatology and Orthopedics of Guizhou University of Traditional Chinese Medicine,Guiyang 550002,Guizhou,China2.The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,Guizhou,China
关键词:
中医药学文献;  数据挖掘;  方剂构成;  组方原则;  聚类分析;  正体类要
Keywords:
medicine pharmacologic literature(TCM);  data mining;  constitution of formula;  formula composing principles;  cluster analysis;  Classification and Treatment of Traumatic Diseases
摘要:
目的:挖掘《正体类要》中治伤内服方剂的用药规律。方法:收集《正体类要》中的治伤内服方剂,利用中医传承辅助平台(V2.5)对数据进行统计分析,挖掘方剂的用药规律。结果:共收集到57首方剂,涉及116味中药,其中出现频次≥5的中药有19味,排在前3位的分别是当归、甘草、人参。57首内服治伤方剂的组方药物中,药性以温性出现频次最多、其次为寒性,药味以甘味出现频次最多、其次为苦和辛味,归经以脾经出现频次最多、其次为肝经; 出现频次≥10的药物组合有8个,排在前3位的为人参-甘草、人参-茯苓、甘草-茯苓; 核心药物组合10个,分别为羌活-防风-细辛、桃仁-红花-瓜蒌、茯苓-甘草-大枣等。经聚类分析得到新处方5首。结论:《正体类要》中治伤内服方剂多采用性温、味甘、归脾经的药物; 核心药物组合以活血化瘀、解表止痛、益气补血药物为主; 以核心药物组合为基础聚类出的内服治伤新方,可为临床用药提供参考,但其疗效有待进一步研究。
Abstract:
Objective:To excavate the clinical medication rules of oral prescriptions for treatment of orthopedic and traumatic diseases in Classification and Treatment of Traumatic Diseases.Methods:The oral prescriptions aimed at treating orthopedic and traumatic diseases were extracted from the Classification and Treatment of Traumatic Diseases and were statistically analyzed by using traditional Chinese medicine inheritance support system(TCMISS)software(V2.5)for excavating the clinical medication rules.Results:Fifty-seven oral prescriptions were included in the final analysis,involving 116 Chinese herbs,among which 19 ones displayed a occurrence frequency of≥5,and the top 3 ones with high occurrence frequency included Angelica sinensis,Glycyrrhiza uralensis and Ginseng Radix et Rhizoma.Among the 57 oral prescriptions,the most frequently appeared Chinese herbs were those with a warm property,followed by the ones with a cold property; and the ones with sweet flavors were more preferred,followed by bitter and pungent flavors,and they mainly acted on the spleen meridians and liver meridians.The occurrence frequency were≥10 in 8 herb combinations,and the top 3 ones with high occurrence frequency included Ginseng Radix et Rhizoma-Glycyrrhiza uralensis,Ginseng Radix et Rhizoma-Poria(TCD)and Glycyrrhiza uralensis-Poria(TCD); The cluster analysis on all the included Chinese herbs generated 10 core herb combinations,namely Notopterygii Rhizoma et Radix-Saposhnikoviae Radix-Asari Radix et Rhizoma(TCD),Persicae Semen-Carthamus tinctorius-Trichosanthis Fructus,Poria(TCD)-Glycyrrhiza uralensis-Jujubae Fructus and so on,and 5 new prescriptions were dug out.Conclusion:The Chinese herbs are often the ones presented with warm property and sweet flavor and mainly act on spleen meridians in the oral prescriptions aimed at treating orthopedic and traumatic diseases in Classification and Treatment of Traumatic Diseases,and the core herb combinations are mainly the ones for activating blood and removing stasis,relieving exterior syndrome and alleviating pain as well as tonifying qi and nourishing blood.The new prescriptions clustered based on core herb combinations can provide references for clinical medication,while their curative effects need to be further studied.

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