[1]黄明翥,周红海,何心愉,等.《医宗金鉴·正骨心法要旨》中治疗伤科瘀肿疼痛方剂的用药规律分析[J].中医正骨,2023,35(10):37-41.
　HUANG Mingzhu,ZHOU Honghai,HE Xinyu,et al.A data mining-based analysis of clinical medication rules of traumatologic prescriptions for treatment of blood stasis,swelling and pain in Yizong Jinjian,Essentials of Bone Orthopedics[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(10):37-41.
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《医宗金鉴·正骨心法要旨》中治疗伤科瘀肿疼痛方剂的用药规律分析()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年10期
页码:
37-41
栏目:
文献研究
出版日期:
2023-10-20

文章信息/Info

Title:
A data mining-based analysis of clinical medication rules of traumatologic prescriptions for treatment of blood stasis,swelling and pain in Yizong Jinjian,Essentials of Bone Orthopedics
作者:
黄明翥; 周红海; 何心愉; 徐涛; 吴周统
广西中医药大学骨伤学院,广西 南宁 530001
Author(s):
HUANG Mingzhu; ZHOU Honghai; HE Xinyu; XU Tao; WU Zhoutong
College of Orthopaedics and Traumatology of Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China
关键词:
中医药学文献;  《医宗金鉴》;  中医骨伤科疾病;  方剂构成;  数据挖掘;  聚类分析
Keywords:
med pharmacol literature TCM;  Yi Zong Jin Jian;  orthopedic traumatologic diseases(TCM);  constitution of formula;  data mining;  cluster analysis
摘要:
目的:分析《医宗金鉴·正骨心法要旨》中治疗伤科瘀肿疼痛方剂的用药规律。方法:收集《医宗金鉴·正骨心法要旨》中治疗伤科瘀肿疼痛的方剂,对组方中药物的出现频次及药性、药味、归经、功效进行统计,分析用药规律。结果:共收集到《医宗金鉴·正骨心法要旨》中治疗瘀肿疼痛的内服、外用方剂57首,涉及中药179味。出现频次≥5的药物有35味,当归出现频次最多。药性出现频次较高的为温、寒、平,药味出现频次较高的为辛、苦、甘,归经主要归肝经、脾经、心经,药物功效主要为补虚、活血、清热。关联药物数最多的药物是当归,规则支持度最高的药物组合为川芎-当归; 增益最高的药物组合为生姜-人参、甘草。核心药物组合有4组,分别为人参-生姜-大枣-茯苓-白术、柴胡-栀子-半夏-黄芩、当归-川芎-熟地黄-白芍、血竭-木香-酒。结论:《医宗金鉴·正骨心法要旨》中治疗伤科瘀肿疼痛的方剂多采用性温、味辛、归肝经的药物,核心药物组合以健脾益气、疏肝清火、补血活血、活血止痛药物为主,用药规律符合其专从血论、气血并重、消补并用的治伤思想。
Abstract:
Objective:To analyze the clinical medication rules of traumatologic prescriptions for treatment of blood stasis,swelling and pain in Yizong Jinjian,Essentials of Bone Orthopedics.Methods:The traumatologic prescriptions aimed at treating blood stasis,swelling and pain were extracted from Yizong Jinjian,Essentials of Bone Orthopedics,and the occurrence frequency,medicinal property,medicinal flavor,meridian tropism and efficacy of each Chinese herbs(CHs)contained in the extracted prescriptions were statistically analyzed for excavating the clinical medication rules.Results:Fifty-seven oral and external-applied prescriptions for treatment of blood stasis,swelling and pain in Yizong Jinjian,Essentials of Bone Orthopedics were included in the final analysis,involving 179 CHs,among which 35 ones displayed a occurrence frequency of≥5,and the most frequently used CH was Angelica Sinensis.The results of statistics showed that,among the 57 oral and external-applied prescriptions,the CHs were often the ones for reinforcing deficiency,activating blood and clearing heat,which were often warm,cold and neutral in property and pungent,bitter and sweet in flavor and mainly acted on the liver meridians,spleen meridians and heart meridians in turn.The results of association rule analysis revealed that the CH with the highest correlation was Angelica Sinensis; the herb combination with the highest support was Chuanxiong Rhizoma-Angelica Sinensis; and the herb combination with the highest gain was Zingiberis Rhizoma Recens-Ginseng Radix et Rhizoma,Glycyrrhiza Uralensis.The results of cluster analysis on the 35 high occurrence frequency herbs generated 4 core herb combinations,namely Ginseng Radix et Rhizoma-Zingiberis Rhizoma Recens-Jujubae Fructus-Poria Cocos-Atractmlodis Macrocephalae Rhizoma,Bupleuri Radix-Gardeniae Fructus-Pinelliae Rhizoma-Scutellaria Baicalensis,Angelica Sinensis-Chuanxiong Rhizoma-Rehmanniae Radix Praeparata-Paeoniae Radix Alba and Draconis Sanguis-Aucklandiae Radix-Medicinal Wine.Conclusion:The CHs are often the ones presented with warm property and pungent flavor and mainly act on liver meridians in the traumatologic prescriptions aimed at treating blood stasis,swelling and pain in Yizong Jinjian,Essentials of Bone Orthopedics,and the core herb combinations are mainly the ones for strengthening spleen and reinforcing Qi,soothing liver and clearing internal heat,nourishing blood and activating blood as well as activating blood for relieving pain.The medication rules conform to the thoughts of focusing on blood,paying equal attention to Qi and blood,and stressing on the combination of elimination and tonification in treatment of orthopaedic and traumatic diseases.

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备注/Memo

备注/Memo:
基金项目:广西壮族自治区中医药局科研课题(GXZYA20220117,20210068)
通讯作者:周红海 E-mail:1310803699@qq.com
更新日期/Last Update: 1900-01-01