[1]王春丽,白玉.手术联合参茸痨疽丸治疗虚寒型慢性骨髓炎的临床研究[J].中医正骨,2014,26(02):16-18.
　Wang Chunli*,Bai Yu..Clinical study on the curative effect of surgery combined with SHENRONG LAOJU pill in the treatment of chronic osteomyelitis of yang-deficiency cold type[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(02):16-18.
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手术联合参茸痨疽丸治疗虚寒型慢性骨髓炎的临床研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期数:
2014年02期
页码:
16-18
栏目:
临床研究
出版日期:
2014-02-20

文章信息/Info

Title:
Clinical study on the curative effect of surgery combined with SHENRONG LAOJU pill in the treatment of chronic osteomyelitis of yang-deficiency cold type
作者:
王春丽; 白玉
河南省郑州市骨科医院,河南 郑州 450052
Author(s):
Wang Chunli*; Bai Yu.
* Zhengzhou Orthopedics Hospital,Zhengzhou 450052,Henan,China
关键词:
骨髓炎 参茸痨疽丸 治疗; 临床研究性
Keywords:
Osteomyelitis;  SHENRONG LAOJU pill;  Therapies; investigational
摘要:
目的:观察手术联合参茸痨疽丸治疗虚寒型慢性骨髓炎的临床疗效。方法:将186例虚寒型慢性骨髓炎患者随机分为2组,每组93例。A组采用常规手术抗生素治疗,B组采用常规手术抗生素联合参茸痨疽丸治疗。比较2组患者的治疗后1年的临床疗效、治疗1个疗程后的生化指标和治疗4个疗程后免疫指标。结果:①临床疗效。治疗后1年A组治愈31例、好转37例、无效25例,B组治愈62例、好转25例、无效6例。B组临床疗效优于A组(Z=-2.405,P=0.019)。②生化指标。治疗1个疗程后A组患者的白细胞计数、红细胞沉降率、超敏C反应蛋白均高于B组,差异有统计学意义[(8.83±2.54)109个·L-1,(5.92±1.64)109个·L-1,t=6.362,P=0.042;(14.16±2.75)mm·h-1,(6.27±3.24)mm·h-1,t=7.238,P=0.034;(2.74±0.78)mg·L-1,(1.76±0.56)mg·L-1,t=5.149,P=0.027]。③免疫指标。治疗4个疗程后A组患者的血清白细胞介素2、白细胞介素6及免疫球蛋白G含量均低于B组,差异均有统计学意义[(1.96±0.27)ng·mL-1,(3.46±0.33)ng·mL-1,t=-7.127,P=0.026;(13.64±2.49)pg·mL-1,(25.08±3.36)pg·mL-1,t=-5.536,P=0.035;(3.75±1.61)mg·mL-1,(5.95±1.76)mg·mL-1,t=-4.268,P=0.028]。结论:手术联合参茸痨疽丸可有效降低虚寒型慢性骨髓炎患者白细胞数量、红细胞沉降率和超敏C反应蛋白,提高白细胞介素2、白细胞介素6及免疫球蛋白G含量,其临床疗效优于常规手术抗生素治疗。
Abstract:
Objective:To observe the clinical effects of surgery combined with SHENRONG LAOJU pill in the treatment of chronic osteomyelitis of yang-deficiency cold type.Methods:One hundred and eighty-six patients with chronic osteomyelitis of yang-deficiency cold type were randomly divided into group A and group B,93 cases in each group.The patients in group A were treated with antibiotics,while the others in group B were treated with antibiotics combined with SHENRONG LAOJU pill.Then the clinical effects after one-year treatment,the biochemical criterion after one-course treatment and the immune indices after four-course treatment were compared between the 2 groups.Results:After one-year treatment,31 patients obtained an excellent result,37 good and 25 poor in group A; while 62 patients obtained an excellent result,25 good and 6 poor in group B.The group B surpassed the group A in the clinical effects(Z=-2.405,P=0.019).After one-course treatment,the number of white blood cells(WBC),the erythrocyte sedimentation rate(ESR)and the high sensitivity C-Reactive Protein(h-CRP)in group A were all higher than that of group B,and there was statistical difference between the 2 groups(8.83+/-2.54 vs 5.92+/-1.64 109/L,t=6.362,P=0.042; 14.16+/-2.75 vs 6.27+/-3.24 mm/h,t=7.238,P=0.034; 2.74+/-0.78 vs 1.76+/-0.56 mg/L,t=5.149,P=0.027).After four-course treatment,the content of serum interleukin-2(IL-2),IL-6 and immunoglobulin G(IgG)in group A were all lower than that of group B,and there was statistical difference between the 2 groups(1.96+/-0.27 vs 3.46+/-0.33 ng/mL,t=-7.127,P=0.026; 13.64+/-2.49 vs 25.08+/-3.36 pg/mL,t=-5.536,P=0.035; 3.75+/-1.61 vs 5.95+/-1.76 mg/mL,t=-4.268,P=0.028).Conclusion:The method of surgery combined with SHENRONG LAOJU pill can reduce the number of WBC,ESR and h-CRP,and increase the content of IL-2,IL-6 and IgG in the treatment of chronic osteomyelitis of yang-deficiency cold type,which curative effect is better than that of antibiotics.

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备注/Memo

备注/Memo:
通讯作者:白玉 E-mail:baiyu6626@sina.com
更新日期/Last Update: 2014-02-20