[1]王西迅,李钧,陈旭辉,等.木豆叶煎液外洗治疗四肢创伤创面的临床观察[J].中医正骨,2013,25(11):8-12.
 Wang Xixun*,Li JJun,Chen Xuhui,et al.Therapeutic effect of cajanus leaf decoction washing on the treatment of wound surfaces in the limbs[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(11):8-12.
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木豆叶煎液外洗治疗四肢创伤创面的临床观察()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期数:
2013年11期
页码:
8-12
栏目:
临床研究
出版日期:
2013-11-30

文章信息/Info

Title:
Therapeutic effect of cajanus leaf decoction washing on the treatment of wound surfaces in the limbs
作者:
王西迅1李钧1陈旭辉2 杨勇1周顺3崔岩1陈波1金成1 禹建春4 胡继超1 舒正华1魏勇1何健1童哲1潘 跃1丁潮琪1
1.中国武装警察部队浙江省总队医院,浙江 嘉兴 314000;
2.浙江新安国际医院,浙江 嘉兴 314000;
3.浙江省平湖市中医院,浙江 平湖 314200;
4.浙江省台州市博爱医院,浙江 台州 318050
Author(s):
Wang Xixun*Li JJunChen XuhuiYang YongZhou ShunCui YanChen BoJin ChengYu JianchunHu JichaoShu ZhenghuaWei YongHe JianTong ZhePan YueDing Chaoqi.*
General Hospital in Zhejiang Province of Armed Police Forces,Jiaxing 314000,Zhejiang,China
关键词:
软组织损伤 伤口愈合 木豆 治疗临床研究性
Keywords:
Soft tissue injuries Wound healing Cajanus Therapiesinvestigational
摘要:
目的:观察木豆叶煎液外洗治疗四肢软组织缺损的临床疗效。方法:将226例软组织缺损患者随机分为2组,每组113例。清创结束后,治疗组用木豆叶煎液外洗处理创面,对照组用5%呋喃西林溶液处理创面。每日2次。观察2组患者的创面愈合率、创面愈合时间、创面分泌物细菌培养结果及临床疗效。结果:①创面愈合率。治疗后不同时间患者的创面愈合率的差异总体上有统计学意义,即存在时间效应(F=111.562,P=0.000); 2组患者治疗后不同时间创面愈合率的组间差异总体上有统计学意义,即存在分组效应(F=1757.082,P=0.000),治疗组各时间点创面愈合率均高于对照组[(54.43±24.77),(42.96±19.99),t=5.171,P=0.006;(83.74±13.79),(55.81±21.59),t=15.746,P=0.000;(94.07±9.28),(65.37±21.80),t=17.163,P=0.000;(97.49±6.16),(77.75±20.76),t=13.875,P=0.000]; 时间因素和分组因素存在交互效应(F=188.500,P=0.003)。②创面愈合时间。治疗组创面愈合时间比对照组短,差异有统计学意义[(33.47±7.22),(43.37±11.39),t=-11.692,P=0.008]。③创面分泌物细菌培养结果。治疗前2组患者创面分泌物细菌培养阳性率比较,差异无统计学意义(χ2=0.398,P=0.528),治疗开始后1周、2周、3周、4周治疗组创面分泌物细菌培养阳性率均低于对照组,差异有统计学意义(χ2=33.275,P=0.000; χ2=20.884,P=0.000; χ2=11.760,P=0.001; χ2=7.706,P=0.006)。④临床疗效。治疗组治愈88例、显效23例、有效2例,对照组治愈12例、显效45例、有效39例、无效17例。治疗组疗效优于对照组(u=1 474.500,P=0.000)。结论:木豆叶煎液能提高创面愈合率,缩短创面愈合时间,抑制创面细菌繁殖,可有效促进四肢软组织创伤创面的愈合。
Abstract:
Objective:To observe the clinical effects of cajanus leaf decoction washing on the treatment of soft tissue defects in the limbs.Methods:Two hundred and twenty-six patients with soft tissue defects were randomly divided into treatment group and control group,113 cases in each group.After debridement,the patients in treatment group were treated with cajanus leaf decoction washing,while the others in control group were treated with 5% nitrofurazone solution washing,2 times a day.Then the wound healing rate,healing time,wound secretion germiculture result and clinical effects were observed between the 2 groups.Results:In general,there was statistical difference in wound healing rate among time points(F=111.562,P=0.000),in other words,there was time effect.There was statistical difference in wound healing rate between the 2 groups in general(F=1757.082,P=0.000),in other words,there was group effect.The wound healing rate of treatment group was higher than that of control group at each time points((54.43+/-24.77),(42.96+/-19.99),t=5.171,P=0.006;(83.74+/-13.79),(55.81+/-21.59),t=15.746,P=0.000;(94.07+/-9.28),(65.37+/-21.80),t=17.163,P=0.000;(97.49+/-6.16),(77.75+/-20.76),t=13.875,P=0.000).There was interaction between time factor and grouping factor(F=188.500,P=0.003).The wound healing time of treatment group was shorter than that of control group,and there was statistical difference between the 2 groups((33.47+/-7.22),(43.37+/-11.39),t=-11.692,P=0.008).There was no statistical difference in the germiculture positive rate of wound secretion between the 2 groups before treatment(χ2=0.398,P=0.528),the germiculture positive rate of wound secretion in treatment group was lower than that of control group 1 week,2 weeks,3 weeks and 4 weeks after treatment,and there were statistical differences between the 2 groups(χ2=33.275,P=0.000; χ2=20.884,P=0.000; χ2=11.760,P=0.001; χ2=7.706,P=0.006).Eighty-eight patients obtained an excellent clinical curative effects,23 good,and 2 fair in the treatment group; while 12 patients obtained an excellent clinical curative effects,45 good,39 fair,and 17 poor in the control group.The treatment group surpassed the control group in the total curative effect(u=1 474.500,P=0.000).Conclusion:The therapy of cajanus leaf decoction washing can improve wound healing rate,shorten the wound healing time,inhibit wound bacteria breeding,so it can promote the wound healing of soft tissue in the limbs effectively.

参考文献/References:

[1] 翟献斌.泰山散瘀膏促进损伤软组织修复的实验研究[J].中医正骨,2012, 24(8): 568-571.
[2] 杨运东,冯秋珍.外用中药促进开放性骨折感染创面愈合的现代药理作用[J].中医正骨, 2000,12(2):119-120.
[3] 中华人民共和国卫生部.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:30.
[4] 李晓黎,程春生.中药外治法促进慢性感染性创面愈合机理进展[J].中医正骨,2007, 19(4): 314-316.
[5] 谭勇海,于海勇,姜苗苗,等.富含血小板血清裂解液治疗皮肤缺损32例[J].中医正骨,2012, 24(7): 513-514.
[6] 海南人民医院药剂科.柳豆叶抗菌成分的初步研究[J].海南医学,1980,01:59-60.
[7] 薛亮,刘旭盛.巨噬细胞在创面愈合中的作用研究进展[J].中华烧伤杂志,2013, 29(1):62-64.
[8] 袁浩,何伟,蔡振基.柳豆叶治疗开放性骨折感染创面40例临床总结[J].广州中医学院学报,1991,8(2):160-163.
[9] 方永奇,黄可儿,谢沙,等.柳豆叶抗炎作用研究[J].中药新药与临床药理,1992,3(2):39-41.
[10] 唐勇,王兵,周学君.木豆制剂外敷对开放创面纤维结合蛋白含量的影响[J].广州中医药大学学报, 1999,16(4):302-304.
[11] 单海民,田涛涛,程真真,等. 手术配合三黄汤加味外洗治疗儿童足跟部辗绞伤 [J].中医正骨,2012, 24(9):687-688.

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备注/Memo

备注/Memo:
2013-05-18收稿 2013-10-09修回
基金项目:浙江省嘉兴市科技计划项目(2009AY2056)
更新日期/Last Update: 2013-11-30