[1]单海民,程春生,李刚,等.Ⅰ型牛胶原蛋白生物膜预防屈指肌腱损伤术后粘连的临床研究[J].中医正骨,2012,24(12):27-29.
　SHAN Hai-min*,CHENG Chun-sheng,LI Gang,et al.Clinical study on the role of biomembrane made of bovine type-Ⅰcollagen protein in the prevention of postoperative finger flexor tendon adhesion formation[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(12):27-29.
点击复制

Ⅰ型牛胶原蛋白生物膜预防屈指肌腱损伤术后粘连的临床研究()
分享到：

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期数:
2012年12期
页码:
27-29
栏目:
临床研究
出版日期:
2012-12-20

文章信息/Info

Title:
Clinical study on the role of biomembrane made of bovine type-Ⅰcollagen protein in the prevention of postoperative finger flexor tendon adhesion formation
作者:
单海民1; 程春生1; 李刚2; 赵治伟1; 程真真1; 石宁宁1; 田涛涛2
1.河南省洛阳正骨医院,河南 洛阳 471002;
2.湖南中医药大学,湖南 长沙 410000
Author(s):
SHAN Hai-min*; CHENG Chun-sheng; LI Gang; ZHAO Zhi-wei; CHENG Zhen-zhen; SHI Ning-ning; TIAN Tao-tao
*Luoyang Orthopedic-Traumatological Hospital,Luoyang 471002,Henan,China
关键词:
手损伤 胶原Ⅰ型 肌腱粘连 治疗; 临床研究性
Keywords:
Hand injuries;  Collagen type Ⅰ;  Adhesion of tendon;  Therapies; investigational
摘要:
目的:观察Ⅰ型牛胶原蛋白生物膜预防屈指肌腱损伤术后粘连的临床疗效和安全性。方法:按要求选取72例手部Ⅱ区新鲜屈指肌腱损伤患者,男43例,女29例。年龄16～55岁,中位数37.5岁。实验方案通过医院伦理委员会的论证。采用随机数字表将72例患者随机分为2组,每组36例。2组均采用改良Kessler肌腱缝合法修复肌腱,治疗组用Ⅰ型牛胶原蛋白生物膜包绕吻合的肌腱断端,对照组在损伤局部不使用任何药物及特殊处理。观察记录患者治疗期间及治疗后血尿常规、生化指标及心电图有无异常,及有无肌腱再断裂等不良事件发生。并于术后第8周采用中华医学会手外科学会手部肌腱修复后评定标准评定2组患者的手部肌腱总主动活动度。结果:①安全性。2组患者术后切口均一期愈合,无感染及肌腱再次断裂; 血尿常规、生化指标及心电图未见异常。②手部肌腱总主动活动度。治疗组优19例,良11例,可5例,差1例; 对照组优8例,良10例,可13例,差5例。治疗组手部肌腱总主动活动度优于对照组(Z=-3.229,P=0.001)。结论:Ⅰ型牛胶原蛋白生物膜能安全、有效地预防屈指肌腱损伤术后粘连。
Abstract:
Objective:To observe the clinical curative effect and safety of biomembrane made of bovine type-Ⅰcollagen protein in the prevention of postoperative finger flexor tendon adhesion formation.Methods:Seventy-two patients with fresh flexor tendon injuries in zoneⅡof hands were selected according to the requirements,male 43 cases,while female 29 cases,ranging in age from 16 to 55 years with a median of 37.5 years.Research Ethics Committee approval was obtained.The 72 patients were randomly divided into 2 groups according to random digits table,36 cases in each group.The injured tendons of patients in the 2 groups were all repaired through modified Kessler tendon suture.Cases in the treatment group were administrated with biomembrane made of bovine type-Ⅰcollagen protein surrounded anastomotic broken ends of tendon,while the others in the control group were administrated without any drug or special treatment in the local injuries.The results of routine blood test,routine urine test,biochemical indicator test and electrocardiogram were observed and recorded during and after the treatment,and the occurrence of tendon re-rupture and other adverse events were also observed and recorded.The total active range of motion of hand tendons in the 2 groups were evaluated according to the repaired hand tendon evaluation standards set up by hand surgery branch of Chinese Medical Association at the 8th week after the operation.Results:①Safety.All of the patients in the 2 groups got primary healing in the operative incisions,without infection and tendon re-rupture; and no abnormal results of routine blood test,routine urine test,biochemical indicator test and electrocardiogram were found in the 2 groups.②Total active range of motion of hand tendons.Nineteen patients got excellent outcomes,11 good,5 fair and 1 poor in the treatment group; while 8 patients got excellent outcomes,10 good,13 fair and 5 poor in the control group.The total active range of motion of hand tendon in the treatment group was better than that in the control group(Z=-3.229,P=0.001).Conclusion:Biomembrane made of bovine type-Ⅰcollagen protein can safely and effectively prevent postoperative finger flexor tendon adhesion formation.

参考文献/References:

[1] 罗程,刘冰冰,欧阳丽斯,等.在肌腱损伤动物模型修复过程中BFGF和Ⅰ型胶原蛋白表达的特征[J].中山大学学报:医学科学版,2011,32(1):32-33.
[2] 胥少汀,葛宝丰,徐印坎.实用骨科学[M].4版.北京:人民军医出版社,2012:608.
[3] 潘达德,顾玉东,侍德,等.中华医学会手外科学会上肢部分功能评定试用标准[J].中华手外科杂志,2000,16(3):130-135.
[4] 毕莹,孔淑静,何文龙,等.医用透明质酸钠薄膜防粘连研究[J].青岛大学学报:工程技术版,2002,17(4):73-77.
[5] 张卫国,姜长明,吕德成.高分子纤维素预防肌腱粘连的验研究[J].实用手外科杂志,2003,17(4):219-220.
[6] 夏长所,洪光祥,李红,等.几丁糖对肌腱腱鞘和腱外膜以及腱内膜细胞增殖和胶原产生的影响[J].中华显微外科杂志,2005,28(2):154-156.
[7] 吴迎波,赵胡瑞.防止肌腱粘连及促进其愈合的研究进展[J].现代生物医学进展,2010,10(4):784-787.
[8] Hurwitz PJ,Weizblit J,Heller D.Experimental coating of flexor tendons with polyvinylpyrrolidone to reduce postoperative adhesions[J].Plast Reconstr Surg,1985,76(5):798-799.
[9] 田明波,李守峰.医用可吸收膜和玻璃酸钠在肌腱修复术中的应用效果分析[J].中医正骨,2011,23(8):17-19.
[10] 孙华.屈指肌腱修复术后的康复护理[J].中国社区医师:医学专业,2012,14(4):323.

相似文献/References:

[1]孙献武,于香兰,邵海燕,等.应用三维动静态平衡康复模式治疗 非脊髓型颈椎病的临床研究[J].中医正骨,2015,27(11):8.
　SUN Xianwu,YU Xianglan,SHAO Haiyan,et al.Clinical study on three-dimensional dynamic and static equilibrium rehabilitation modality in the treatment of non-myelopathy type cervical spondylosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):8.
[2]宁兴明,伍亮,王廷,等.五禽戏配合核心肌力训练治疗非特异性腰痛的临床研究[J].中医正骨,2015,27(11):25.
　NING Xingming,WU Liang,WANG Ting,et al.Clinical study on five mimic-animal boxing combined with core muscular strength exercise for the treatment of nonspecific low back pain[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):25.
[3]沈海,刘昕,彭玉兰,等.复位架牵引下手法复位经皮穿针内固定治疗 儿童肱骨髁上骨折的临床研究[J].中医正骨,2015,27(10):1.
　SHEN Hai,LIU Xin,PENG Yulan,et al.Clinical study on reduction frame traction combined with manipulative reduction and percutaneous Kirschner wire internal fixation for treatment of humeral supracondylar fractures in children[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):1.
[4]葛波涌,王玉波,王明太,等.交锁髓内钉内固定治疗胫骨干骨折的临床研究[J].中医正骨,2015,27(10):8.
　GE Boyong,WANG Yubo,WANG Mingtai,et al.Clinical study on the internal fixation with interlocking intramedullary nail for the treatment of tibial shaft fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):8.
[5]梁朝,蔡静怡,闫立,等.针刀疗法改善膝骨关节炎早期疼痛症状的疗效评价[J].中医正骨,2015,27(09):9.
　LIANG Zhao,CAI Jingyi,YAN Li,et al.Evaluation of the curative effect of needle-knife therapy for relieving knee pain in patients with early knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):9.
[6]邢金明.切开复位锁定钢板内固定术和人工半肩关节置换术 治疗老年肱骨近端复杂骨折的对比研究[J].中医正骨,2015,27(08):11.
　XING Jinming.A retrospective trial of open reduction and locking plate internal fixation versus artificial shoulder hemiarthroplasty for complicated proximal humeral fractures in old patients[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):11.
[7]帅波,沈霖,杨艳萍,等.加味青娥丸治疗膝骨关节炎的作用机制研究[J].中医正骨,2015,27(07):15.
　SHUAI Bo,SHEN Lin,YANG Yanping,et al.Study on the mechanism of action of Jiawei Qing'e Wan(加味青娥丸)for the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):15.
[8]黄杨,王昌兴,邹阳.AO钛制弹性髓内钉内固定与切开复位钢板内固定治疗 小儿肱骨干中下段骨折的比较研究[J].中医正骨,2015,27(07):22.
　HUNAG Yang,WANG Changxing,ZOU Yang.A comparative study of AO titanium elastic stable intramedullary nail internal fixation versus open reduction plate osteosynthesis for the treatment of mid-distal humeral fractures in children[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):22.
[9]梅其杰,袁长深,段戡,等.壮药骨痹方烫熨联合运动疗法治疗膝骨关节炎的临床研究[J].中医正骨,2015,27(07):27.
　MEI Qijie,YUAN Changshen,DUAN Kan,et al.Clinical study of the curative effect of hot compressing and rubbing with packet of Gubi Fang(骨痹方)combined with exercise therapy in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):27.
[10]王丹辉,张燕,刘丽娟,等.重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白 关节腔注射联合中药薰洗治疗膝骨关节炎的临床研究[J].中医正骨,2015,27(07):31.
　WANG Danhui,ZHANG Yan,LIU Lijuan,et al.Clinical study on intra-articular injection of TypeⅡrecombinant human tumor necrosis factor receptor-Fc fusion protein combined with Chinese herbal steaming and washing therapy for treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):31.

备注/Memo

备注/Memo:
基金项目:河南省省属科研单位社会公益项目专项资金
更新日期/Last Update: 2012-12-20