[1]朱让腾,应有荣,童静玲,等.膝骨性关节炎滑液中骨桥蛋白的表达及临床意义[J].中医正骨,2011,23(11):7-9.
　ZHU Rang-teng*,YING You-rong,TONG Jing-ling,et al.Expression and clinical significance of OPN in synovial fluid of patients with knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(11):7-9.
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膝骨性关节炎滑液中骨桥蛋白的表达及临床意义()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第23卷
期数:
2011年11期
页码:
7-9
栏目:
基础研究
出版日期:
2011-11-30

文章信息/Info

Title:
Expression and clinical significance of OPN in synovial fluid of patients with knee osteoarthritis
作者:
朱让腾; 应有荣; 童静玲; 高福明; 罗利飞; 张德清; 应光华
台州恩泽医疗中心路桥医院,浙江 台州 318050
Author(s):
ZHU Rang-teng*; YING You-rong; TONG Jing-ling; et al.*
Luqiao branch of Taizhou Hospital,Taizhou 318050,Zhejiang, China
关键词:
骨关节炎; 膝 骨桥蛋白
Keywords:
osteoarthritis; knee;  osteopontin
摘要:
目的:探讨骨桥蛋白(osteopontin,OPN)在膝骨性关节炎关节滑液中的表达及其临床意义。方法:检测膝骨性关节炎(osteoarthritis,OA)患者和创伤骨折患者膝关节滑液中OPN的含量,并加以比较。结果:OA组关节滑液中OPN含量为(3978.7±459.1)ng·L-1,对照组关节滑液中OPN含量为(874. 2±259.3)ng·L-1,两组数值经统计学分析,差异有统计学意义(P<0.05)。两组关节液中OPN含量与OA的病变严重程度(关节镜下分级),经Spearman等级相关检验,两者呈正相关(P<0.05)。结论:OPN与膝骨性关节炎的发病和发展有关。
Abstract:
Objective:To investigate the expression and clinical significance of osteopontin(OPN)in in synovial fluid of patients with knee osteoarthritis.Methods:Content of OPN in synovial fluid was measured and compared from the patients with knee osteoarthritis and with fracture.Results:Synovial fluid OPN in OA group was 3978.7±459.1 ng·L-1,874. 2±259.31 ng·L-1 in the fracture group.There was significant difference between the 2 groups by statistical analysis(P<0.05).Subsequent analysis showed that the OPN level in synovial fluid significantly was correlated with severity of disease(P<0.05)by Spearman rank correlation method.Conclusion:The data suggest that expression of OPN in synovial fluid is related to progressive joint damage.

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更新日期/Last Update: 1900-01-01